SIRT3 overexpression and epigenetic silencing of catalase regulate ROS accumulation in CLL cells activating AXL signaling axis

SIRT3 overexpression and epigenetic silencing of catalase regulate ROS accumulation in CLL cells activating AXL signaling axis

Abstract Mitochondrial metabolism is the key source for abundant ROS in chronic lymphocytic leukemia (CLL) cells. Here, we detected significantly lower superoxide anion (O2 −) levels with increased accumulation of hydrogen peroxide (H2O2) in CLL cells vs. normal B-cells. Further analysis indicated t...

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Bibliographic Details
Main Authors: Guru P. Maiti, Sutapa Sinha, Hasan Mahmud, Justin Boysen, Mariana T. Mendez, Sara K. Vesely, Jennifer Holter-Chakrabarty, Neil E. Kay, Asish K. Ghosh
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Blood Cancer Journal
Online Access:https://doi.org/10.1038/s41408-021-00484-6

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