The Synthesis of Fragrant Natural Products from Santalum album L.: (+)-(Z)-?-Santalol and (–)-(Z)-?-Santalol
The synthetic challenges associated with the selective synthesis of ?-Santalene (1), (Z)-?-Santalol (2), ?-Santalene (3), and most importantly (Z)-?-Santalol (4) have interested the world's synthetic chemists for decades. These molecules, lovely examples of nature's exquisite cre...
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2017-12-01
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| Series: | CHIMIA |
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| Online Access: | https://www.chimia.ch/chimia/article/view/1690 |
| _version_ | 1818296311659626496 |
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| author | Anthony A. Birkbeck |
| author_facet | Anthony A. Birkbeck |
| author_sort | Anthony A. Birkbeck |
| collection | DOAJ |
| description |
The synthetic challenges associated with the selective synthesis of ?-Santalene (1), (Z)-?-Santalol (2), ?-Santalene (3), and most importantly (Z)-?-Santalol (4) have interested the world's synthetic chemists for decades.
These molecules, lovely examples of nature's exquisite creations, have been isolated from East Indian Sandalwood Oil (Santalum album L.) and have stimulated chemists to develop new and efficient methodologies to synthesize them. The synthesis and evolution of various approaches to the
[2.2.1]bicycloheptane ring system present in ?-Santalene (3) and the even more challenging selective synthesis of the (Z)-allylic alcohol sidechain present in both (Z)-?-Santalol (2) and ((Z)-?-Santalol (4) will be covered in this review.
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| first_indexed | 2024-12-13T04:01:32Z |
| format | Article |
| id | doaj.art-3a82253a58e14a358e072d6cf261b7e5 |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-12-13T04:01:32Z |
| publishDate | 2017-12-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-3a82253a58e14a358e072d6cf261b7e52022-12-22T00:00:26ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242017-12-01711210.2533/chimia.2017.823The Synthesis of Fragrant Natural Products from Santalum album L.: (+)-(Z)-?-Santalol and (–)-(Z)-?-SantalolAnthony A. Birkbeck0Firmenich SA, Corporate R&D Division, P.O. Box 239, CH-1211 Geneva 8, Switzerland. alec.birkbeck@firmenich.com The synthetic challenges associated with the selective synthesis of ?-Santalene (1), (Z)-?-Santalol (2), ?-Santalene (3), and most importantly (Z)-?-Santalol (4) have interested the world's synthetic chemists for decades. These molecules, lovely examples of nature's exquisite creations, have been isolated from East Indian Sandalwood Oil (Santalum album L.) and have stimulated chemists to develop new and efficient methodologies to synthesize them. The synthesis and evolution of various approaches to the [2.2.1]bicycloheptane ring system present in ?-Santalene (3) and the even more challenging selective synthesis of the (Z)-allylic alcohol sidechain present in both (Z)-?-Santalol (2) and ((Z)-?-Santalol (4) will be covered in this review. https://www.chimia.ch/chimia/article/view/1690(z)-allylic alcoholSandalwood oilα-santalolβ-santalolSantalum album |
| spellingShingle | Anthony A. Birkbeck The Synthesis of Fragrant Natural Products from Santalum album L.: (+)-(Z)-?-Santalol and (–)-(Z)-?-Santalol CHIMIA (z)-allylic alcohol Sandalwood oil α-santalol β-santalol Santalum album |
| title | The Synthesis of Fragrant Natural Products from Santalum album L.: (+)-(Z)-?-Santalol and (–)-(Z)-?-Santalol |
| title_full | The Synthesis of Fragrant Natural Products from Santalum album L.: (+)-(Z)-?-Santalol and (–)-(Z)-?-Santalol |
| title_fullStr | The Synthesis of Fragrant Natural Products from Santalum album L.: (+)-(Z)-?-Santalol and (–)-(Z)-?-Santalol |
| title_full_unstemmed | The Synthesis of Fragrant Natural Products from Santalum album L.: (+)-(Z)-?-Santalol and (–)-(Z)-?-Santalol |
| title_short | The Synthesis of Fragrant Natural Products from Santalum album L.: (+)-(Z)-?-Santalol and (–)-(Z)-?-Santalol |
| title_sort | synthesis of fragrant natural products from santalum album l z santalol and z santalol |
| topic | (z)-allylic alcohol Sandalwood oil α-santalol β-santalol Santalum album |
| url | https://www.chimia.ch/chimia/article/view/1690 |
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