Heparin-free veno-arterial extracorporeal membrane oxygenation in lung transplantation: a retrospective cohort study
Abstract Background In lung transplantation (LTx) surgery, veno-arterial extracorporeal membrane oxygenation (VA-ECMO) can provide mechanical circulatory support to patients with cardiopulmonary failure. However, the use of heparin in the administration of ECMO can increase blood loss during LTx. Th...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Journal of Cardiothoracic Surgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13019-024-02721-y |
| _version_ | 1797199178805280768 |
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| author | ZhaoMin Huang Jiayi Zheng Mingyang Wang Shaoting Zeng Miaoting Huang Shuyi Peng Jiajun Li Jiaming Ji Quan Chen Xin Xu Chao Yang GuiLin Peng Hanyu Yang |
| author_facet | ZhaoMin Huang Jiayi Zheng Mingyang Wang Shaoting Zeng Miaoting Huang Shuyi Peng Jiajun Li Jiaming Ji Quan Chen Xin Xu Chao Yang GuiLin Peng Hanyu Yang |
| author_sort | ZhaoMin Huang |
| collection | DOAJ |
| description | Abstract Background In lung transplantation (LTx) surgery, veno-arterial extracorporeal membrane oxygenation (VA-ECMO) can provide mechanical circulatory support to patients with cardiopulmonary failure. However, the use of heparin in the administration of ECMO can increase blood loss during LTx. This study aimed to evaluate the safety of heparin-free V-A ECMO strategies. Methods From September 2019 to April 2022, patients who underwent lung transplantation at the First Affiliated Hospital of Guangzhou Medical University were retrospectively reviewed. A total of 229 patients were included, including 117 patients in the ECMO group and 112 in the non-ECMO group. Result There was no significant difference in the incidence of thrombus events and bleeding requiring reoperation between the two groups. The in-hospital survival rate after single lung transplantation (SLTx) was 81.08%in the ECMO group and 85.14% in the Non-ECMO group, (P = 0.585). The in-hospital survival rate after double lung transplantation (DLTx) was 80.00% in the ECMO group and 92.11% in the Non-ECMO groups (P = 0.095). Conclusions In conclusion, the findings of this study suggest that the heparin-free V-A ECMO strategy in lung transplantation is a safe approach that does not increase the incidence of perioperative thrombotic events or bleeding requiring reoperation. |
| first_indexed | 2024-04-24T07:11:38Z |
| format | Article |
| id | doaj.art-3a8244a7624e4c6eb075ff5e25200775 |
| institution | Directory Open Access Journal |
| issn | 1749-8090 |
| language | English |
| last_indexed | 2024-04-24T07:11:38Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj.art-3a8244a7624e4c6eb075ff5e252007752024-04-21T11:29:50ZengBMCJournal of Cardiothoracic Surgery1749-80902024-04-011911610.1186/s13019-024-02721-yHeparin-free veno-arterial extracorporeal membrane oxygenation in lung transplantation: a retrospective cohort studyZhaoMin Huang0Jiayi Zheng1Mingyang Wang2Shaoting Zeng3Miaoting Huang4Shuyi Peng5Jiajun Li6Jiaming Ji7Quan Chen8Xin Xu9Chao Yang10GuiLin Peng11Hanyu Yang12Department of anesthesia, The First Affiliated Hospital of Guangzhou Medical UniversityThe First Clinical Medical College, Guangzhou Medical UniversityThe First Clinical Medical College, Guangzhou Medical UniversityThe First Clinical Medical College, Guangzhou Medical UniversityThe First Clinical Medical College, Guangzhou Medical UniversityThe First Clinical Medical College, Guangzhou Medical UniversityThe First Clinical Medical College, Guangzhou Medical UniversityThe First Clinical Medical College, Guangzhou Medical UniversityThe First Clinical Medical College, Guangzhou Medical UniversityDepartment of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical UniversityDepartment of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical UniversityDepartment of Thoracic Surgery, The First Affiliated Hospital of Guangzhou Medical UniversityDepartment of anesthesia, The First Affiliated Hospital of Guangzhou Medical UniversityAbstract Background In lung transplantation (LTx) surgery, veno-arterial extracorporeal membrane oxygenation (VA-ECMO) can provide mechanical circulatory support to patients with cardiopulmonary failure. However, the use of heparin in the administration of ECMO can increase blood loss during LTx. This study aimed to evaluate the safety of heparin-free V-A ECMO strategies. Methods From September 2019 to April 2022, patients who underwent lung transplantation at the First Affiliated Hospital of Guangzhou Medical University were retrospectively reviewed. A total of 229 patients were included, including 117 patients in the ECMO group and 112 in the non-ECMO group. Result There was no significant difference in the incidence of thrombus events and bleeding requiring reoperation between the two groups. The in-hospital survival rate after single lung transplantation (SLTx) was 81.08%in the ECMO group and 85.14% in the Non-ECMO group, (P = 0.585). The in-hospital survival rate after double lung transplantation (DLTx) was 80.00% in the ECMO group and 92.11% in the Non-ECMO groups (P = 0.095). Conclusions In conclusion, the findings of this study suggest that the heparin-free V-A ECMO strategy in lung transplantation is a safe approach that does not increase the incidence of perioperative thrombotic events or bleeding requiring reoperation.https://doi.org/10.1186/s13019-024-02721-yVeno-arterial extracorporeal membrane oxygenationHeparin freeThrombus events |
| spellingShingle | ZhaoMin Huang Jiayi Zheng Mingyang Wang Shaoting Zeng Miaoting Huang Shuyi Peng Jiajun Li Jiaming Ji Quan Chen Xin Xu Chao Yang GuiLin Peng Hanyu Yang Heparin-free veno-arterial extracorporeal membrane oxygenation in lung transplantation: a retrospective cohort study Journal of Cardiothoracic Surgery Veno-arterial extracorporeal membrane oxygenation Heparin free Thrombus events |
| title | Heparin-free veno-arterial extracorporeal membrane oxygenation in lung transplantation: a retrospective cohort study |
| title_full | Heparin-free veno-arterial extracorporeal membrane oxygenation in lung transplantation: a retrospective cohort study |
| title_fullStr | Heparin-free veno-arterial extracorporeal membrane oxygenation in lung transplantation: a retrospective cohort study |
| title_full_unstemmed | Heparin-free veno-arterial extracorporeal membrane oxygenation in lung transplantation: a retrospective cohort study |
| title_short | Heparin-free veno-arterial extracorporeal membrane oxygenation in lung transplantation: a retrospective cohort study |
| title_sort | heparin free veno arterial extracorporeal membrane oxygenation in lung transplantation a retrospective cohort study |
| topic | Veno-arterial extracorporeal membrane oxygenation Heparin free Thrombus events |
| url | https://doi.org/10.1186/s13019-024-02721-y |
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