Monocyte-neutrophil entanglement in glioblastoma
Glioblastoma (GBM) is the most belligerent and frequent brain tumor in adults. Research over the past two decades has provided increased knowledge of the genomic and molecular landscape of GBM and highlighted the presence of a high degree of inter- and intratumor heterogeneity within the neoplastic...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Clinical Investigation
2023-01-01
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| Series: | The Journal of Clinical Investigation |
| Online Access: | https://doi.org/10.1172/JCI163451 |
| _version_ | 1797634493281992704 |
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| author | Dinorah Friedmann-Morvinski Dolores Hambardzumyan |
| author_facet | Dinorah Friedmann-Morvinski Dolores Hambardzumyan |
| author_sort | Dinorah Friedmann-Morvinski |
| collection | DOAJ |
| description | Glioblastoma (GBM) is the most belligerent and frequent brain tumor in adults. Research over the past two decades has provided increased knowledge of the genomic and molecular landscape of GBM and highlighted the presence of a high degree of inter- and intratumor heterogeneity within the neoplastic compartment. It is now appreciated that GBMs are composed of multiple distinct and impressionable neoplastic and non-neoplastic cell types that form the unique brain tumor microenvironment (TME). Non-neoplastic cells in the TME form reciprocal interactions with neoplastic cells to promote tumor growth and invasion, and together they influence the tumor response to standard-of-care therapies as well as emerging immunotherapies. One of the most prevalent non-neoplastic cell types in the GBM TME are myeloid cells, the most abundant of which are of hematopoietic origin, including monocytes/monocyte-derived macrophages. Less abundant, although still a notable presence, are neutrophils of hematopoietic origin and intrinsic brain-resident microglia. In this Review we focus on neutrophils and monocytes that infiltrate tumors from the blood circulation, their heterogeneity, and their interactions with neoplastic cells and other non-neoplastic cells in the TME. We conclude with an overview of challenges in targeting these cells and discuss avenues for therapeutic exploitation to improve the dismal outcomes of patients with GBM. |
| first_indexed | 2024-03-11T12:08:36Z |
| format | Article |
| id | doaj.art-3a833f48826b44aa929c1cda165df26a |
| institution | Directory Open Access Journal |
| issn | 1558-8238 |
| language | English |
| last_indexed | 2024-03-11T12:08:36Z |
| publishDate | 2023-01-01 |
| publisher | American Society for Clinical Investigation |
| record_format | Article |
| series | The Journal of Clinical Investigation |
| spelling | doaj.art-3a833f48826b44aa929c1cda165df26a2023-11-07T16:19:42ZengAmerican Society for Clinical InvestigationThe Journal of Clinical Investigation1558-82382023-01-011331Monocyte-neutrophil entanglement in glioblastomaDinorah Friedmann-MorvinskiDolores HambardzumyanGlioblastoma (GBM) is the most belligerent and frequent brain tumor in adults. Research over the past two decades has provided increased knowledge of the genomic and molecular landscape of GBM and highlighted the presence of a high degree of inter- and intratumor heterogeneity within the neoplastic compartment. It is now appreciated that GBMs are composed of multiple distinct and impressionable neoplastic and non-neoplastic cell types that form the unique brain tumor microenvironment (TME). Non-neoplastic cells in the TME form reciprocal interactions with neoplastic cells to promote tumor growth and invasion, and together they influence the tumor response to standard-of-care therapies as well as emerging immunotherapies. One of the most prevalent non-neoplastic cell types in the GBM TME are myeloid cells, the most abundant of which are of hematopoietic origin, including monocytes/monocyte-derived macrophages. Less abundant, although still a notable presence, are neutrophils of hematopoietic origin and intrinsic brain-resident microglia. In this Review we focus on neutrophils and monocytes that infiltrate tumors from the blood circulation, their heterogeneity, and their interactions with neoplastic cells and other non-neoplastic cells in the TME. We conclude with an overview of challenges in targeting these cells and discuss avenues for therapeutic exploitation to improve the dismal outcomes of patients with GBM.https://doi.org/10.1172/JCI163451 |
| spellingShingle | Dinorah Friedmann-Morvinski Dolores Hambardzumyan Monocyte-neutrophil entanglement in glioblastoma The Journal of Clinical Investigation |
| title | Monocyte-neutrophil entanglement in glioblastoma |
| title_full | Monocyte-neutrophil entanglement in glioblastoma |
| title_fullStr | Monocyte-neutrophil entanglement in glioblastoma |
| title_full_unstemmed | Monocyte-neutrophil entanglement in glioblastoma |
| title_short | Monocyte-neutrophil entanglement in glioblastoma |
| title_sort | monocyte neutrophil entanglement in glioblastoma |
| url | https://doi.org/10.1172/JCI163451 |
| work_keys_str_mv | AT dinorahfriedmannmorvinski monocyteneutrophilentanglementinglioblastoma AT doloreshambardzumyan monocyteneutrophilentanglementinglioblastoma |