Diffuse Leptomeningeal Glioneuronal Tumor with FGFR1 Mutation in a 29-Year-Old Male
This study reports on diffuse leptomeningeal glioneuronal tumor (DL-GNT) in a 29- year-old male. DLGNT is a rare central nervous system (CNS) tumor mostly seen in children and only few cases have been reported in adult patients. Our patient presented with a chronic headache that lasted for five m...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Korean Society of Radiology
2023-07-01
|
| Series: | Journal of the Korean Society of Radiology |
| Subjects: | |
| Online Access: | https://doi.org/10.3348/jksr.2022.0120 |
| _version_ | 1797769693539336192 |
|---|---|
| author | Minsu Kim Ki Rim Lee Gheeyoung Choe Kihwan Hwang Jae Hyoung Kim |
| author_facet | Minsu Kim Ki Rim Lee Gheeyoung Choe Kihwan Hwang Jae Hyoung Kim |
| author_sort | Minsu Kim |
| collection | DOAJ |
| description | This study reports on diffuse leptomeningeal glioneuronal tumor (DL-GNT) in a 29- year-old male. DLGNT
is a rare central nervous system (CNS) tumor mostly seen in children and only few cases have
been reported in adult patients. Our patient presented with a chronic headache that lasted for five
months. MR imaging showed mild hydrocephalus, multiple rim-enhancing nodular lesions in the suprasellar
cistern, diffuse leptomeningeal enhancement in the lumbosacral area, and multiple small
non-enhancing cyst-appearing lesions not suppressed on fluid attenuated inversion recovery (FLAIR)
images in the bilateral basal ganglia, thalami, and cerebral hemispheres. Under the impression of
germ cell tumor with leptomeningeal seeding, the patient underwent trans-sphenoidal tumor removal.
DL-GNT was pathologically confirmed and FGFR1 mutation was detected through a next-generation
sequencing test. In conclusion, a combination of leptomeningeal enhancement and multiple parenchymal
non-enhancing cyst-appearing lesions not suppressed on FLAIR images may be helpful for differential
diagnosis despite overlapping imaging features with many other CNS diseases that have leptomeningeal
enhancement. |
| first_indexed | 2024-03-12T21:12:44Z |
| format | Article |
| id | doaj.art-3a83b617fb1d4a8eb939512bb652d3ba |
| institution | Directory Open Access Journal |
| issn | 2951-0805 |
| language | English |
| last_indexed | 2024-03-12T21:12:44Z |
| publishDate | 2023-07-01 |
| publisher | The Korean Society of Radiology |
| record_format | Article |
| series | Journal of the Korean Society of Radiology |
| spelling | doaj.art-3a83b617fb1d4a8eb939512bb652d3ba2023-07-30T09:48:52ZengThe Korean Society of RadiologyJournal of the Korean Society of Radiology2951-08052023-07-01844970976https://doi.org/10.3348/jksr.2022.0120Diffuse Leptomeningeal Glioneuronal Tumor with FGFR1 Mutation in a 29-Year-Old MaleMinsu KimKi Rim LeeGheeyoung ChoeKihwan HwangJae Hyoung KimThis study reports on diffuse leptomeningeal glioneuronal tumor (DL-GNT) in a 29- year-old male. DLGNT is a rare central nervous system (CNS) tumor mostly seen in children and only few cases have been reported in adult patients. Our patient presented with a chronic headache that lasted for five months. MR imaging showed mild hydrocephalus, multiple rim-enhancing nodular lesions in the suprasellar cistern, diffuse leptomeningeal enhancement in the lumbosacral area, and multiple small non-enhancing cyst-appearing lesions not suppressed on fluid attenuated inversion recovery (FLAIR) images in the bilateral basal ganglia, thalami, and cerebral hemispheres. Under the impression of germ cell tumor with leptomeningeal seeding, the patient underwent trans-sphenoidal tumor removal. DL-GNT was pathologically confirmed and FGFR1 mutation was detected through a next-generation sequencing test. In conclusion, a combination of leptomeningeal enhancement and multiple parenchymal non-enhancing cyst-appearing lesions not suppressed on FLAIR images may be helpful for differential diagnosis despite overlapping imaging features with many other CNS diseases that have leptomeningeal enhancement.https://doi.org/10.3348/jksr.2022.0120brain neoplasmsmeningeal neoplasmscystsmagnetic resonance imagingadult |
| spellingShingle | Minsu Kim Ki Rim Lee Gheeyoung Choe Kihwan Hwang Jae Hyoung Kim Diffuse Leptomeningeal Glioneuronal Tumor with FGFR1 Mutation in a 29-Year-Old Male Journal of the Korean Society of Radiology brain neoplasms meningeal neoplasms cysts magnetic resonance imaging adult |
| title | Diffuse Leptomeningeal Glioneuronal Tumor with FGFR1 Mutation in a 29-Year-Old Male |
| title_full | Diffuse Leptomeningeal Glioneuronal Tumor with FGFR1 Mutation in a 29-Year-Old Male |
| title_fullStr | Diffuse Leptomeningeal Glioneuronal Tumor with FGFR1 Mutation in a 29-Year-Old Male |
| title_full_unstemmed | Diffuse Leptomeningeal Glioneuronal Tumor with FGFR1 Mutation in a 29-Year-Old Male |
| title_short | Diffuse Leptomeningeal Glioneuronal Tumor with FGFR1 Mutation in a 29-Year-Old Male |
| title_sort | diffuse leptomeningeal glioneuronal tumor with fgfr1 mutation in a 29 year old male |
| topic | brain neoplasms meningeal neoplasms cysts magnetic resonance imaging adult |
| url | https://doi.org/10.3348/jksr.2022.0120 |
| work_keys_str_mv | AT minsukim diffuseleptomeningealglioneuronaltumorwithfgfr1mutationina29yearoldmale AT kirimlee diffuseleptomeningealglioneuronaltumorwithfgfr1mutationina29yearoldmale AT gheeyoungchoe diffuseleptomeningealglioneuronaltumorwithfgfr1mutationina29yearoldmale AT kihwanhwang diffuseleptomeningealglioneuronaltumorwithfgfr1mutationina29yearoldmale AT jaehyoungkim diffuseleptomeningealglioneuronaltumorwithfgfr1mutationina29yearoldmale |