Antimicrobial Peptide LL-37 Facilitates Intracellular Uptake of RNA Aptamer Apt 21-2 Without Inducing an Inflammatory or Interferon Response

Antimicrobial Peptide LL-37 Facilitates Intracellular Uptake of RNA Aptamer Apt 21-2 Without Inducing an Inflammatory or Interferon Response

RNA aptamers are synthetic single stranded RNA oligonucleotides that function analogously to antibodies. Recently, they have shown promise for use in treating inflammatory skin disease as, unlike antibody-based biologics, they are able to enter the skin following topical administration. However, it...

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Bibliographic Details
Main Authors: Tom Macleod, Joseph Ward, Adewonuola A. Alase, Charlie Bridgewood, Miriam Wittmann, Nicola J. Stonehouse
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
LL-37
RNA aptamer
skin
inflammation
interferon response
safety
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00857/full

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