Persisting post-infection symptoms 2 years after a large waterborne outbreak of Cryptosporidium hominis in northern Sweden
Abstract Objectives In 2010–2011, a large waterborne outbreak of Cryptosporidium hominis affected the city of Östersund in Sweden. Previous findings had suggested that gastrointestinal symptoms can persist for up to 11 months after the initial infection. Here we investigated whether the parasite cou...
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| Format: | Article |
| Language: | English |
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BMC
2018-08-01
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| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13104-018-3721-y |
| _version_ | 1828355430388072448 |
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| author | Mikael Lilja Micael Widerström Johan Lindh |
| author_facet | Mikael Lilja Micael Widerström Johan Lindh |
| author_sort | Mikael Lilja |
| collection | DOAJ |
| description | Abstract Objectives In 2010–2011, a large waterborne outbreak of Cryptosporidium hominis affected the city of Östersund in Sweden. Previous findings had suggested that gastrointestinal symptoms can persist for up to 11 months after the initial infection. Here we investigated whether the parasite could cause sequelae in infected individuals up to 28 months after the outbreak. We compared cases linked to the outbreak and the previous follow-up study with non-cases regarding symptoms present up to 28 months after the initial infection. We investigated whether cases were more likely to report a list of symptoms at follow-up compared to non-cases, calculating odds ratio and 95% confidence interval obtained through logistic regression. Results A total of 559 individuals (215 cases) were included in the study. Forty-eight percent of the outbreak cases reported symptoms at follow-up. Compared to non-cases, cases were more likely to report watery diarrhea, diarrhea, abdominal pain, fatigue, nausea, headache, or joint stiffness/pain/discomfort at follow-up after adjusting for age and sex. Our findings suggest that gastrointestinal symptoms and joint pain can persist several years after the initial Cryptosporidium infection and should be regarded as a potential cause of unexplained gastrointestinal symptoms or joint pain in people who have had this infection. |
| first_indexed | 2024-04-14T02:42:13Z |
| format | Article |
| id | doaj.art-3a847469307148e9b6d63c2c16101167 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-04-14T02:42:13Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-3a847469307148e9b6d63c2c161011672022-12-22T02:16:50ZengBMCBMC Research Notes1756-05002018-08-011111510.1186/s13104-018-3721-yPersisting post-infection symptoms 2 years after a large waterborne outbreak of Cryptosporidium hominis in northern SwedenMikael Lilja0Micael Widerström1Johan Lindh2Department of Public Health and Clinical Medicine, Unit of Clinical Research Center-Östersund, Umeå UniversityDepartment of Clinical Microbiology, Unit of Communicable Disease Control and Prevention-Östersund, Umeå UniversityDepartment of Cell and Molecular Biology, Microbiology, Uppsala UniversityAbstract Objectives In 2010–2011, a large waterborne outbreak of Cryptosporidium hominis affected the city of Östersund in Sweden. Previous findings had suggested that gastrointestinal symptoms can persist for up to 11 months after the initial infection. Here we investigated whether the parasite could cause sequelae in infected individuals up to 28 months after the outbreak. We compared cases linked to the outbreak and the previous follow-up study with non-cases regarding symptoms present up to 28 months after the initial infection. We investigated whether cases were more likely to report a list of symptoms at follow-up compared to non-cases, calculating odds ratio and 95% confidence interval obtained through logistic regression. Results A total of 559 individuals (215 cases) were included in the study. Forty-eight percent of the outbreak cases reported symptoms at follow-up. Compared to non-cases, cases were more likely to report watery diarrhea, diarrhea, abdominal pain, fatigue, nausea, headache, or joint stiffness/pain/discomfort at follow-up after adjusting for age and sex. Our findings suggest that gastrointestinal symptoms and joint pain can persist several years after the initial Cryptosporidium infection and should be regarded as a potential cause of unexplained gastrointestinal symptoms or joint pain in people who have had this infection.http://link.springer.com/article/10.1186/s13104-018-3721-yCryptosporidiumSequelaeDiarrhea |
| spellingShingle | Mikael Lilja Micael Widerström Johan Lindh Persisting post-infection symptoms 2 years after a large waterborne outbreak of Cryptosporidium hominis in northern Sweden BMC Research Notes Cryptosporidium Sequelae Diarrhea |
| title | Persisting post-infection symptoms 2 years after a large waterborne outbreak of Cryptosporidium hominis in northern Sweden |
| title_full | Persisting post-infection symptoms 2 years after a large waterborne outbreak of Cryptosporidium hominis in northern Sweden |
| title_fullStr | Persisting post-infection symptoms 2 years after a large waterborne outbreak of Cryptosporidium hominis in northern Sweden |
| title_full_unstemmed | Persisting post-infection symptoms 2 years after a large waterborne outbreak of Cryptosporidium hominis in northern Sweden |
| title_short | Persisting post-infection symptoms 2 years after a large waterborne outbreak of Cryptosporidium hominis in northern Sweden |
| title_sort | persisting post infection symptoms 2 years after a large waterborne outbreak of cryptosporidium hominis in northern sweden |
| topic | Cryptosporidium Sequelae Diarrhea |
| url | http://link.springer.com/article/10.1186/s13104-018-3721-y |
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