Comparison of postoperative analgesia and side effects in pediatric laparoscopic surgery with morphine and nalbuphine
Summary: There is currently no consensus on the optimal perioperative pain management strategy involving specific opioids. This study aims to compare the postoperative analgesia, the associated side effects between nalbuphine and morphine in children undergoing laparoscopic surgery. One hundred nine...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S258900422400508X |
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| author | Jia Chen Cheng-Yu Wang John Wei Zhong Yu-Hang Cai Jianmin Zhang Fang Wang Mazhong Zhang Hongbin Gu Hong-Yu Ma Zhen Wang Junzheng Wu Hua-Cheng Liu |
| author_facet | Jia Chen Cheng-Yu Wang John Wei Zhong Yu-Hang Cai Jianmin Zhang Fang Wang Mazhong Zhang Hongbin Gu Hong-Yu Ma Zhen Wang Junzheng Wu Hua-Cheng Liu |
| author_sort | Jia Chen |
| collection | DOAJ |
| description | Summary: There is currently no consensus on the optimal perioperative pain management strategy involving specific opioids. This study aims to compare the postoperative analgesia, the associated side effects between nalbuphine and morphine in children undergoing laparoscopic surgery. One hundred ninety children were randomly assigned to nalbuphine (0.2 mg/kg) or morphine (0.2 mg/kg). Nalbuphine’s analgesic effect was non-inferior to morphine, with similar total rescue analgesic consumption during PACU stay (0.03 ± 0.05mg vs. 0.04 ± 0.06 mg, p > 0.05). Nalbuphine group had a lower incidence of respiratory depression (RR ≤ 10/min) (4.8% vs. 38.6%, p < 0.001), PONV (2.4% vs. 18.1%, p = 0.002), and pruritus (0% vs. 16.9%, p < 0.001) than morphine. Additionally, nalbuphine showed a shorter laryngeal mask airway removal time (13.9 [12.7, 15.1]) compared with morphine (17.0 [15.1, 18.9], p = 0.011). Nalbuphine provides equipotent analgesia with significantly lower incidences of respiratory depression, PONV, and pruritus compared with morphine in pediatric laparoscopic surgery. |
| first_indexed | 2024-04-25T01:40:53Z |
| format | Article |
| id | doaj.art-3a88c20494f742b7bf3faa2c73f02037 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-25T01:40:53Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-3a88c20494f742b7bf3faa2c73f020372024-03-08T05:19:11ZengElsevieriScience2589-00422024-03-01273109287Comparison of postoperative analgesia and side effects in pediatric laparoscopic surgery with morphine and nalbuphineJia Chen0Cheng-Yu Wang1John Wei Zhong2Yu-Hang Cai3Jianmin Zhang4Fang Wang5Mazhong Zhang6Hongbin Gu7Hong-Yu Ma8Zhen Wang9Junzheng Wu10Hua-Cheng Liu11Department of Anaesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University; Key Laboratory of Anaesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Anaesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University; Key Laboratory of Anaesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Anaesthesiology and Pain Management, University of Texas Southwestern Medical Centre, Dallas, TX, USADepartment of Anaesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University; Key Laboratory of Anaesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Anesthesiology, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, ChinaDepartment of Anesthesiology, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, ChinaDepartment of Anesthesiology, Shanghai Children’s Medical Center, Shanghai 200127, ChinaDepartment of Anesthesiology, Shanghai Children’s Medical Center, Shanghai 200127, ChinaDepartment of Anaesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University; Key Laboratory of Anaesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, ChinaLaboratory Medicine Center, Allergy Center, Department of Transfusion Medicine, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaDepartment of Anesthesia and Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA; Corresponding authorDepartment of Anaesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University; Key Laboratory of Paediatric Anaesthesiology, Ministry of Education, Wenzhou Medical University; Key Laboratory of Anaesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China; Corresponding authorSummary: There is currently no consensus on the optimal perioperative pain management strategy involving specific opioids. This study aims to compare the postoperative analgesia, the associated side effects between nalbuphine and morphine in children undergoing laparoscopic surgery. One hundred ninety children were randomly assigned to nalbuphine (0.2 mg/kg) or morphine (0.2 mg/kg). Nalbuphine’s analgesic effect was non-inferior to morphine, with similar total rescue analgesic consumption during PACU stay (0.03 ± 0.05mg vs. 0.04 ± 0.06 mg, p > 0.05). Nalbuphine group had a lower incidence of respiratory depression (RR ≤ 10/min) (4.8% vs. 38.6%, p < 0.001), PONV (2.4% vs. 18.1%, p = 0.002), and pruritus (0% vs. 16.9%, p < 0.001) than morphine. Additionally, nalbuphine showed a shorter laryngeal mask airway removal time (13.9 [12.7, 15.1]) compared with morphine (17.0 [15.1, 18.9], p = 0.011). Nalbuphine provides equipotent analgesia with significantly lower incidences of respiratory depression, PONV, and pruritus compared with morphine in pediatric laparoscopic surgery.http://www.sciencedirect.com/science/article/pii/S258900422400508XHealth sciencesMedicineMedical specialtySurgeryPharmacologyNatural sciences |
| spellingShingle | Jia Chen Cheng-Yu Wang John Wei Zhong Yu-Hang Cai Jianmin Zhang Fang Wang Mazhong Zhang Hongbin Gu Hong-Yu Ma Zhen Wang Junzheng Wu Hua-Cheng Liu Comparison of postoperative analgesia and side effects in pediatric laparoscopic surgery with morphine and nalbuphine iScience Health sciences Medicine Medical specialty Surgery Pharmacology Natural sciences |
| title | Comparison of postoperative analgesia and side effects in pediatric laparoscopic surgery with morphine and nalbuphine |
| title_full | Comparison of postoperative analgesia and side effects in pediatric laparoscopic surgery with morphine and nalbuphine |
| title_fullStr | Comparison of postoperative analgesia and side effects in pediatric laparoscopic surgery with morphine and nalbuphine |
| title_full_unstemmed | Comparison of postoperative analgesia and side effects in pediatric laparoscopic surgery with morphine and nalbuphine |
| title_short | Comparison of postoperative analgesia and side effects in pediatric laparoscopic surgery with morphine and nalbuphine |
| title_sort | comparison of postoperative analgesia and side effects in pediatric laparoscopic surgery with morphine and nalbuphine |
| topic | Health sciences Medicine Medical specialty Surgery Pharmacology Natural sciences |
| url | http://www.sciencedirect.com/science/article/pii/S258900422400508X |
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