The antihelminth drug rafoxanide reverses chromosomal-mediated colistin-resistance in Klebsiella pneumoniae

The antihelminth drug rafoxanide reverses chromosomal-mediated colistin-resistance in Klebsiella pneumoniae

ABSTRACT The emergence and rapid spread of multi-drug-resistant (MDR) bacteria pose a serious threat to global healthcare. Although the synergistic effect of rafoxanide and colistin was reported, little is known regarding the potential mechanism of this synergy, particularly against chromosomal-medi...

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Bibliographic Details
Main Authors:	Rongjia Han, Jiabao Xing, Huarun Sun, Zeyu Guo, Kaifang Yi, Gongzheng Hu, Yajun Zhai, Tony Velkov, Hua Wu
Format:	Article
Language:	English
Published:	American Society for Microbiology 2023-10-01
Series:	mSphere
Subjects:	rafoxanide colistin resistance chromosomal-mediated colistin-resistant Klebsiella pneumoniae reversing resistance transcriptomic analysis
Online Access:	https://journals.asm.org/doi/10.1128/msphere.00234-23

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