High frequency of the risk allele of rs4132601 and rs11978267 from the IKZF1 gene in indigenous Mexican population
Abstract Background IKZF1 is a relevant gene associated with the pathogenesis of acute lymphoblastic leukemia, and the rs4132601 (T>G) and rs11978267 (A>G) polymorphisms have been associated with the development of this disease in several populations. The aim of this study was to determine the...
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| Format: | Article |
| Language: | English |
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Wiley
2021-02-01
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| Series: | Molecular Genetics & Genomic Medicine |
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| Online Access: | https://doi.org/10.1002/mgg3.1589 |
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| author | Jorge Gutiérrez‐Franco Miriam Fabiola Ayón‐Pérez Ma. de Jesús Durán‐Avelar Norberto Vibanco‐Pérez Diego Eduardo Sánchez‐Jasso Dulce Guadalupe Bañuelos‐Aguayo Jaime Sánchez‐Meza Helia Judith Pimentel‐Gutiérrez José Francisco Zambrano‐Zaragoza Juan Manuel Agraz‐Cibrián Alejandro Vázquez‐Reyes |
| author_facet | Jorge Gutiérrez‐Franco Miriam Fabiola Ayón‐Pérez Ma. de Jesús Durán‐Avelar Norberto Vibanco‐Pérez Diego Eduardo Sánchez‐Jasso Dulce Guadalupe Bañuelos‐Aguayo Jaime Sánchez‐Meza Helia Judith Pimentel‐Gutiérrez José Francisco Zambrano‐Zaragoza Juan Manuel Agraz‐Cibrián Alejandro Vázquez‐Reyes |
| author_sort | Jorge Gutiérrez‐Franco |
| collection | DOAJ |
| description | Abstract Background IKZF1 is a relevant gene associated with the pathogenesis of acute lymphoblastic leukemia, and the rs4132601 (T>G) and rs11978267 (A>G) polymorphisms have been associated with the development of this disease in several populations. The aim of this study was to determine the allelic and genotypic frequencies of the rs4132601 and rs11978267 polymorphisms in two indigenous Mexican groups (Cora and Huichol) and Mestizo populations from Nayarit, Mexico, and compare them with the frequencies of both polymorphisms in other populations of the world. Methods One hundred, 116, and 100 subjects from the Mestizo, Huichol, and Cora populations, respectively, all of them residents of the state of Nayarit, Mexico, were analyzed. The frequencies of rs4132601 and rs11978267 were determined by allelic discrimination using TaqMan assays. Results The allelic frequencies of rs4132601 were as follows: Mestizo group T = 0.74, G = 0.26; Cora T = 0.745, G = 0.255; and Huichol T = 0.47, G = 0.53. In the case of the rs11978267 polymorphism, the allelic frequencies were Mestizo A = 0.745, G = 0.255; Cora A = 0.735, G = 0.265; and Huichol A = 0.457, G = 0.543. For each population, both polymorphisms were in Hardy–Weinberg equilibrium. Conclusion The Huichol population from Nayarit presented the highest frequencies of the risk allele reported to date in the whole world for both rs4132601 and rs11978267 polymorphisms. |
| first_indexed | 2024-03-07T23:15:49Z |
| format | Article |
| id | doaj.art-3a8afc731bb34152b26e6a363903b51b |
| institution | Directory Open Access Journal |
| issn | 2324-9269 |
| language | English |
| last_indexed | 2024-03-07T23:15:49Z |
| publishDate | 2021-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Genetics & Genomic Medicine |
| spelling | doaj.art-3a8afc731bb34152b26e6a363903b51b2024-02-21T11:37:44ZengWileyMolecular Genetics & Genomic Medicine2324-92692021-02-0192n/an/a10.1002/mgg3.1589High frequency of the risk allele of rs4132601 and rs11978267 from the IKZF1 gene in indigenous Mexican populationJorge Gutiérrez‐Franco0Miriam Fabiola Ayón‐Pérez1Ma. de Jesús Durán‐Avelar2Norberto Vibanco‐Pérez3Diego Eduardo Sánchez‐Jasso4Dulce Guadalupe Bañuelos‐Aguayo5Jaime Sánchez‐Meza6Helia Judith Pimentel‐Gutiérrez7José Francisco Zambrano‐Zaragoza8Juan Manuel Agraz‐Cibrián9Alejandro Vázquez‐Reyes10Laboratorio de Inmunología Unidad Académica de Ciencias Químico‐Biológicas y Farmacéuticas Universidad Autónoma de Nayarit Tepic Nayarit MéxicoLaboratorios de Investigación en Biología Molecular e Inmunología Unidad Académica de Ciencias Químico Biológicas y Farmacéuticas Universidad Autónoma de Nayarit Tepic Nayarit MéxicoLaboratorios de Investigación en Biología Molecular e Inmunología Unidad Académica de Ciencias Químico Biológicas y Farmacéuticas Universidad Autónoma de Nayarit Tepic Nayarit MéxicoLaboratorios de Investigación en Biología Molecular e Inmunología Unidad Académica de Ciencias Químico Biológicas y Farmacéuticas Universidad Autónoma de Nayarit Tepic Nayarit MéxicoLaboratorios de Investigación en Biología Molecular e Inmunología Unidad Académica de Ciencias Químico Biológicas y Farmacéuticas Universidad Autónoma de Nayarit Tepic Nayarit MéxicoLaboratorios de Investigación en Biología Molecular e Inmunología Unidad Académica de Ciencias Químico Biológicas y Farmacéuticas Universidad Autónoma de Nayarit Tepic Nayarit MéxicoLaboratorios de Investigación en Biología Molecular e Inmunología Unidad Académica de Ciencias Químico Biológicas y Farmacéuticas Universidad Autónoma de Nayarit Tepic Nayarit MéxicoCharitéUniversitätsmedizin, Virchow‐Klinikum Berlin GermanyLaboratorio de Inmunología Unidad Académica de Ciencias Químico‐Biológicas y Farmacéuticas Universidad Autónoma de Nayarit Tepic Nayarit MéxicoLaboratorio de Inmunología Unidad Académica de Ciencias Químico‐Biológicas y Farmacéuticas Universidad Autónoma de Nayarit Tepic Nayarit MéxicoLaboratorios de Investigación en Biología Molecular e Inmunología Unidad Académica de Ciencias Químico Biológicas y Farmacéuticas Universidad Autónoma de Nayarit Tepic Nayarit MéxicoAbstract Background IKZF1 is a relevant gene associated with the pathogenesis of acute lymphoblastic leukemia, and the rs4132601 (T>G) and rs11978267 (A>G) polymorphisms have been associated with the development of this disease in several populations. The aim of this study was to determine the allelic and genotypic frequencies of the rs4132601 and rs11978267 polymorphisms in two indigenous Mexican groups (Cora and Huichol) and Mestizo populations from Nayarit, Mexico, and compare them with the frequencies of both polymorphisms in other populations of the world. Methods One hundred, 116, and 100 subjects from the Mestizo, Huichol, and Cora populations, respectively, all of them residents of the state of Nayarit, Mexico, were analyzed. The frequencies of rs4132601 and rs11978267 were determined by allelic discrimination using TaqMan assays. Results The allelic frequencies of rs4132601 were as follows: Mestizo group T = 0.74, G = 0.26; Cora T = 0.745, G = 0.255; and Huichol T = 0.47, G = 0.53. In the case of the rs11978267 polymorphism, the allelic frequencies were Mestizo A = 0.745, G = 0.255; Cora A = 0.735, G = 0.265; and Huichol A = 0.457, G = 0.543. For each population, both polymorphisms were in Hardy–Weinberg equilibrium. Conclusion The Huichol population from Nayarit presented the highest frequencies of the risk allele reported to date in the whole world for both rs4132601 and rs11978267 polymorphisms.https://doi.org/10.1002/mgg3.1589ALLgenetic polymorphismIKZF1Indigenous Mexican |
| spellingShingle | Jorge Gutiérrez‐Franco Miriam Fabiola Ayón‐Pérez Ma. de Jesús Durán‐Avelar Norberto Vibanco‐Pérez Diego Eduardo Sánchez‐Jasso Dulce Guadalupe Bañuelos‐Aguayo Jaime Sánchez‐Meza Helia Judith Pimentel‐Gutiérrez José Francisco Zambrano‐Zaragoza Juan Manuel Agraz‐Cibrián Alejandro Vázquez‐Reyes High frequency of the risk allele of rs4132601 and rs11978267 from the IKZF1 gene in indigenous Mexican population Molecular Genetics & Genomic Medicine ALL genetic polymorphism IKZF1 Indigenous Mexican |
| title | High frequency of the risk allele of rs4132601 and rs11978267 from the IKZF1 gene in indigenous Mexican population |
| title_full | High frequency of the risk allele of rs4132601 and rs11978267 from the IKZF1 gene in indigenous Mexican population |
| title_fullStr | High frequency of the risk allele of rs4132601 and rs11978267 from the IKZF1 gene in indigenous Mexican population |
| title_full_unstemmed | High frequency of the risk allele of rs4132601 and rs11978267 from the IKZF1 gene in indigenous Mexican population |
| title_short | High frequency of the risk allele of rs4132601 and rs11978267 from the IKZF1 gene in indigenous Mexican population |
| title_sort | high frequency of the risk allele of rs4132601 and rs11978267 from the ikzf1 gene in indigenous mexican population |
| topic | ALL genetic polymorphism IKZF1 Indigenous Mexican |
| url | https://doi.org/10.1002/mgg3.1589 |
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