YI 1.4 Increases in Circulating Trimethylamine-N-Oxide Contribute to the Development of Age-Related Aortic Stiffness in Humans and Mice

YI 1.4 Increases in Circulating Trimethylamine-N-Oxide Contribute to the Development of Age-Related Aortic Stiffness in Humans and Mice

Age-related increases in aortic stiffness, assessed by pulse wave velocity (PWV), predict cardiovascular (CV)-related mortality, but the upstream drivers are incompletely understood. Purpose: To determine if higher circulating levels of the gut microbiome-derived metabolite trimethylamine-N-oxide (...

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Bibliographic Details
Main Authors: Abigail G Casso, Rachel A Gioscia-Ryan, Zachary J Sapinsley, Nicholas S VanDongen, Amy E Bazzoni, Andrew P Neilson, Melanie C Zigler, Kevin P Davy, Douglas R Seals, Vienna E Brunt
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Artery Research
Subjects:
Aging
stiffness
metabolites
translational
Online Access:https://www.atlantis-press.com/article/125950031/view

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