In silico and in vivo analysis of Toxoplasma gondii epitopes by correlating survival data with peptide–MHC-I binding affinities

In silico and in vivo analysis of Toxoplasma gondii epitopes by correlating survival data with peptide–MHC-I binding affinities

Background: Protein antigens comprising peptide motifs with high binding affinity to major histocompatibility complex class I (MHC-I) molecules are expected to induce a stronger cytotoxic T-lymphocyte response and thus provide better protection against infection with microorganisms where cytotoxic T...

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Bibliographic Details
Main Authors: Si-Yang Huang, Maria Risager Jensen, Carina Agerbo Rosenberg, Xing-Quan Zhu, Eskild Petersen, Thomas Vorup-Jensen
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:International Journal of Infectious Diseases
Subjects:
Vaccine antigens
In silico prediction
MHC class I
Toxoplasma gondii
Online Access:http://www.sciencedirect.com/science/article/pii/S120197121631027X

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