Injury-related cell death and proteoglycan loss in articular cartilage: Numerical model combining necrosis, reactive oxygen species, and inflammatory cytokines.

Injury-related cell death and proteoglycan loss in articular cartilage: Numerical model combining necrosis, reactive oxygen species, and inflammatory cytokines.

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Osteoarthritis (OA) is a common musculoskeletal disease that leads to deterioration of articular cartilage, joint pain, and decreased quality of life. When OA develops after a joint injury, it is designated as post-traumatic OA (PTOA). The etiology of PTOA remains poorly understood, but it is known...

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Bibliographic Details
Main Authors: Joonas P Kosonen, Atte S A Eskelinen, Gustavo A Orozco, Petteri Nieminen, Donald D Anderson, Alan J Grodzinsky, Rami K Korhonen, Petri Tanska
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1010337

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https://doi.org/10.1371/journal.pcbi.1010337

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