A Retrospective Study of Paediatric Dengue Cases in a Tertiary Care Hospital in Southern India
Introduction: Dengue is an important arthropod-borne viral infection in humans and is the second most important reemerging tropical disease. Children are particularly at risk of developing severe dengue and clinically identifying such cases are often a challenge. Aim: To characterise the clinical an...
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| Format: | Article |
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JCDR Research and Publications Private Limited
2018-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/11756/34710_CE[Ra]_F(Sh)_PF1(A_SHU)_PFA(AnG)_PN(SL).pdf |
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| author | Padmanabhan P Athira Ozhiparambil A Jagan Padma Umadevi Komaravolu Pragnatha P Menon Veena |
| author_facet | Padmanabhan P Athira Ozhiparambil A Jagan Padma Umadevi Komaravolu Pragnatha P Menon Veena |
| author_sort | Padmanabhan P Athira |
| collection | DOAJ |
| description | Introduction: Dengue is an important arthropod-borne viral infection in humans and is the second most important reemerging tropical disease. Children are particularly at risk of developing severe dengue and clinically identifying such cases are often a challenge. Aim: To characterise the clinical and laboratory risk factors of dengue fever and its severity in children. Materials and Methods: Retrospective evaluation of demographics, clinical, laboratory findings and outcome of suspected dengue fever in children admitted to the hospital between Jan 2015 - Feb 2017 was performed to identify risk factors of dengue fever and its severity. Results: During the study period, a total of 211 children were clinically suspected on the admission as dengue fever, 34 of these were serologically confirmed dengue positive. A 74% (27/34) of these were primary dengue infections. The mean age of the dengue cohort was 7.6 years (±s.d. 4.8) with 59% (20/34) being boys. Based on 2009 WHO clinical criteria, 16 were identified as Dengue with warning Signs (DS), 7 as Dengue Without warning Signs (DWS) while 11 were identified as Severe Dengue (SD). Some of the frequently observed clinical features were fever (31/34), headache (5/34), thrombocytopenia (9/34), leukopenia (4/34) and rash (5/34). The mean WBC in children with severe dengue was 7.9 % (s.d.±5.0) with elevated monocytes 12.2 % (s.d.±3.5) compared to 11.3% (s.d.±5.8) and 6.6% (s.d.±2.0) in children with DS and DWS respectively. Transaminitis was more frequently observed in severe dengue. Conclusion: Clinical and laboratory parameters of acute febrile illness in children can act as early prognosticators of dengue fever and its severity. |
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| id | doaj.art-3a8d06e5543a43c399fea46541994999 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-12T09:15:52Z |
| publishDate | 2018-07-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-3a8d06e5543a43c399fea465419949992022-12-22T03:38:51ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2018-07-01127SC01SC0610.7860/JCDR/2018/34710.11756A Retrospective Study of Paediatric Dengue Cases in a Tertiary Care Hospital in Southern IndiaPadmanabhan P Athira0Ozhiparambil A Jagan1Padma Umadevi2Komaravolu Pragnatha3P Menon Veena4Student, Department of Pharmacology, Amrita School of Pharmacy, Amrita University, Kochi, Kerala, India.Lecturer, Department of Clinical Virology, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India.Associate Professor, Department of Pharmacology, Amrita School of Pharmacy, Amrita University, Kochi, Kerala, India.Pediatric Consultant, Department of Pediatric, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India.Professor, Department of Clinical Virology, Amrita Institute of Medical Sciences, Amrita University, Kochi, Kerala, India.Introduction: Dengue is an important arthropod-borne viral infection in humans and is the second most important reemerging tropical disease. Children are particularly at risk of developing severe dengue and clinically identifying such cases are often a challenge. Aim: To characterise the clinical and laboratory risk factors of dengue fever and its severity in children. Materials and Methods: Retrospective evaluation of demographics, clinical, laboratory findings and outcome of suspected dengue fever in children admitted to the hospital between Jan 2015 - Feb 2017 was performed to identify risk factors of dengue fever and its severity. Results: During the study period, a total of 211 children were clinically suspected on the admission as dengue fever, 34 of these were serologically confirmed dengue positive. A 74% (27/34) of these were primary dengue infections. The mean age of the dengue cohort was 7.6 years (±s.d. 4.8) with 59% (20/34) being boys. Based on 2009 WHO clinical criteria, 16 were identified as Dengue with warning Signs (DS), 7 as Dengue Without warning Signs (DWS) while 11 were identified as Severe Dengue (SD). Some of the frequently observed clinical features were fever (31/34), headache (5/34), thrombocytopenia (9/34), leukopenia (4/34) and rash (5/34). The mean WBC in children with severe dengue was 7.9 % (s.d.±5.0) with elevated monocytes 12.2 % (s.d.±3.5) compared to 11.3% (s.d.±5.8) and 6.6% (s.d.±2.0) in children with DS and DWS respectively. Transaminitis was more frequently observed in severe dengue. Conclusion: Clinical and laboratory parameters of acute febrile illness in children can act as early prognosticators of dengue fever and its severity.https://jcdr.net/articles/PDF/11756/34710_CE[Ra]_F(Sh)_PF1(A_SHU)_PFA(AnG)_PN(SL).pdfarthropodflavivirusfeverhaemoconcentrationthrombocytopenia |
| spellingShingle | Padmanabhan P Athira Ozhiparambil A Jagan Padma Umadevi Komaravolu Pragnatha P Menon Veena A Retrospective Study of Paediatric Dengue Cases in a Tertiary Care Hospital in Southern India Journal of Clinical and Diagnostic Research arthropod flavivirus fever haemoconcentration thrombocytopenia |
| title | A Retrospective Study of Paediatric Dengue Cases in a Tertiary Care Hospital in Southern India |
| title_full | A Retrospective Study of Paediatric Dengue Cases in a Tertiary Care Hospital in Southern India |
| title_fullStr | A Retrospective Study of Paediatric Dengue Cases in a Tertiary Care Hospital in Southern India |
| title_full_unstemmed | A Retrospective Study of Paediatric Dengue Cases in a Tertiary Care Hospital in Southern India |
| title_short | A Retrospective Study of Paediatric Dengue Cases in a Tertiary Care Hospital in Southern India |
| title_sort | retrospective study of paediatric dengue cases in a tertiary care hospital in southern india |
| topic | arthropod flavivirus fever haemoconcentration thrombocytopenia |
| url | https://jcdr.net/articles/PDF/11756/34710_CE[Ra]_F(Sh)_PF1(A_SHU)_PFA(AnG)_PN(SL).pdf |
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