Extracellular vesicles released by adipose tissue-derived mesenchymal stromal/stem cells from obese pigs fail to repair the injured kidney

Extracellular vesicles released by adipose tissue-derived mesenchymal stromal/stem cells from obese pigs fail to repair the injured kidney

Aims: Mesenchymal stromal/stem cell (MSC)-derived extracellular vesicles (EVs) shuttle select MSC contents and are endowed with an ability to repair ischemic tissues. We hypothesized that exposure to cardiovascular risk factors may alter the microRNA cargo of MSC-derived EVs, blunting their capacity...

Full description

Bibliographic Details
Main Authors:	Alfonso Eirin, Christopher M. Ferguson, Xiang-Yang Zhu, Ishran M. Saadiq, Hui Tang, Amir Lerman, Lilach O. Lerman
Format:	Article
Language:	English
Published:	Elsevier 2020-08-01
Series:	Stem Cell Research
Subjects:	Metabolic syndrome Renovascular disease Stem cells MicroRNA
Online Access:	http://www.sciencedirect.com/science/article/pii/S1873506120301781

Similar Items

Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles Elicit Better Preservation of the Intra-Renal Microvasculature Than Renal Revascularization in Pigs with Renovascular Disease
by: Christopher M. Ferguson, et al.
Published: (2021-03-01)

IL-10 partly mediates the ability of MSC-derived extracellular vesicles to attenuate myocardial damage in experimental metabolic renovascular hypertension
by: Yamei Jiang, et al.
Published: (2022-09-01)

Senescent Kidney Cells in Hypertensive Patients Release Urinary Extracellular Vesicles
by: Adrian Santelli, et al.
Published: (2019-06-01)

Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells
by: Yongxin Li, et al.
Published: (2020-08-01)

Correction to: Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells
by: Yongxin Li, et al.
Published: (2020-10-01)

The Micro-RNA Cargo of Extracellular Vesicles Released by Human Adipose Tissue-Derived Mesenchymal Stem Cells Is Modified by Obesity
by: Alfonso Eirin, et al.
Published: (2021-05-01)

Mesenchymal stem cell-derived extracellular vesicles for kidney repair: current status and looming challenges
by: Arash Aghajani Nargesi, et al.
Published: (2017-12-01)

Mesenchymal Stem Cell-Derived Extracellular Vesicles Improve the Renal Microvasculature in Metabolic Renovascular Disease in Swine
by: Alfonso Eirin, et al.
Published: (2018-07-01)

Comparable in vitro Function of Human Liver-Derived and Adipose Tissue-Derived Mesenchymal Stromal Cells: Implications for Cell-Based Therapy
by: Furkan Yigitbilek, et al.
Published: (2021-03-01)

Integrated transcriptomic and proteomic analysis of the molecular cargo of extracellular vesicles derived from porcine adipose tissue-derived mesenchymal stem cells.
by: Alfonso Eirin, et al.
Published: (2017-01-01)

Restoration of Mitochondrial Cardiolipin Attenuates Cardiac Damage in Swine Renovascular Hypertension
by: Alfonso Eirin, et al.
Published: (2016-06-01)

The metabolic syndrome modifies the mRNA expression profile of extracellular vesicles derived from porcine mesenchymal stem cells
by: Yu Meng, et al.
Published: (2018-07-01)

Effects of Elamipretide on Autophagy in Renal Cells of Pigs with Metabolic Syndrome
by: Siting Hong, et al.
Published: (2022-09-01)

Obesity and dyslipidemia are associated with partially reversible modifications to DNA hydroxymethylation of apoptosis- and senescence-related genes in swine adipose-derived mesenchymal stem/stromal cells
by: Logan M. Glasstetter, et al.
Published: (2023-05-01)

Revascularización renal
by: Francisco Valdés Echeñique
Published: (2017-01-01)

Tratamento endovascular da estenose da artéria renal em rim único Endovascular treatment of renal stenosis in solitary kidney
by: Ana Terezinha Guillaumon, et al.
Published: (2008-06-01)

Urinary Extracellular Vesicles as Biomarkers of Kidney Disease: From Diagnostics to Therapeutics
by: In O. Sun, et al.
Published: (2020-05-01)

Nephrectomy with Autotransplantation—A Key Treasure
by: Sofia Mesquita, et al.
Published: (2024-03-01)

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Dendritic Cell Maturation and Function
by: Monica Reis, et al.
Published: (2018-11-01)

Alterations in genetic and protein content of swine adipose tissue-derived mesenchymal stem cells in the metabolic syndrome
by: Aditya S. Pawar, et al.
Published: (2019-05-01)

Eficácia clínica da revascularização renal percutânea com implante de stent em pacientes com doença renovascular aterosclerótica Clinical efficacy of percutaneous renal revascularization with stent placement in atherosclerotic renovascular disease
by: Janaína Andréa Altemar Gonçalves, et al.
Published: (2007-01-01)

Nefropatia isquêmica Ischemic nephropathy
by: Marcelo Salame, et al.
Published: (2012-12-01)

Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Wound Healing
by: Arulkumar Nallakumarasamy, et al.
Published: (2022-10-01)

The Role of Mesenchymal Stromal Cells-Derived Small Extracellular Vesicles in Diabetes and Its Chronic Complications
by: Fu-Xing-Zi Li, et al.
Published: (2021-12-01)

Early Rapid Decline in Kidney Function in Medically Managed Patients With Atherosclerotic Renal Artery Stenosis
by: Emily L. Cooper, et al.
Published: (2019-06-01)

Anesthetic management of hypertensive crisis in a three-year-old patient with undiagnosed severe renal artery stenosis: a case report
by: Sang-hee Park, et al.
Published: (2014-10-01)

Global epigenetic alterations of mesenchymal stem cells in obesity: the role of vitamin C reprogramming
by: Mohsen Afarideh, et al.
Published: (2021-07-01)

Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells
by: Sabena M. Conley, et al.
Published: (2020-03-01)

Metabolic Syndrome Is Associated With Altered mRNA and miRNA Content in Human Circulating Extracellular Vesicles
by: Yongxin Li, et al.
Published: (2021-08-01)

Renal Regenerative Potential of Extracellular Vesicles Derived from miRNA-Engineered Mesenchymal Stromal Cells
by: Marta Tapparo, et al.
Published: (2019-05-01)

Secretome of Mesenchymal Stromal Cells Prevents Myofibroblasts Differentiation by Transferring Fibrosis-Associated microRNAs within Extracellular Vesicles
by: Nataliya Basalova, et al.
Published: (2020-05-01)

Increased arterial distensibility and renovascular hypertension in Goldenhar syndrome Aumento de distensibilidade arterial e hipertensão renovascular na Sindrome de Goldenhar
by: Luciano F. Drager, et al.
Published: (2005-04-01)

Extra-anatomic bypass can treat renovascular hypertension due to atherosclerotic atypical aortic coarctation
by: Camila Villacreses, MD, et al.
Published: (2023-03-01)

Contemporary treatment of renovascular hypertension
by: A.V. Khokhlov, et al.
Published: (2017-06-01)

The role of nephrectomy of the atrophic kidney in bearers of renovascular hypertension
by: Myrian J. Thomaz, et al.
Published: (2010-04-01)

Effects of Captopril and Losartan on Cardiac Stereology in Rats with Renovascular Hypertension
by: Ali Akbar Nekooeian, et al.
Published: (2021-05-01)

Low-Energy Shockwave Treatment Promotes Endothelial Progenitor Cell Homing to the Stenotic Pig Kidney
by: Yu Zhao, et al.
Published: (2020-04-01)

MiRNA Profiles of Extracellular Vesicles Secreted by Mesenchymal Stromal Cells—Can They Predict Potential Off-Target Effects?
by: Timo Z. Nazari-Shafti, et al.
Published: (2020-09-01)

Therapeutic effects of adipose-tissue-derived mesenchymal stromal cells and their extracellular vesicles in experimental silicosis
by: Elga Bandeira, et al.
Published: (2018-05-01)

Role of microRNA Shuttled in Small Extracellular Vesicles Derived From Mesenchymal Stem/Stromal Cells for Osteoarticular Disease Treatment
by: Eliana Lara-Barba, et al.
Published: (2021-11-01)