Investigating Therapeutic Effects of Indole Derivatives Targeting Inflammation and Oxidative Stress in Neurotoxin-Induced Cell and Mouse Models of Parkinson’s Disease

Investigating Therapeutic Effects of Indole Derivatives Targeting Inflammation and Oxidative Stress in Neurotoxin-Induced Cell and Mouse Models of Parkinson’s Disease

Neuroinflammation and oxidative stress have been emerging as important pathways contributing to Parkinson’s disease (PD) pathogenesis. In PD brains, the activated microglia release inflammatory factors such as interleukin (IL)-β, IL-6, tumor necrosis factor (TNF)-α, and nitric oxide (NO), which incr...

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Bibliographic Details
Main Authors: Ya-Jen Chiu, Chih-Hsin Lin, Chung-Yin Lin, Pei-Ning Yang, Yen-Shi Lo, Yu-Chieh Chen, Chiung-Mei Chen, Yih-Ru Wu, Ching-Fa Yao, Kuo-Hsuan Chang, Guey-Jen Lee-Chen
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
Parkinson’s disease
therapeutics
NLRP3 inflammasome
neuroinflammation
oxidative stress
MPP<sup>+</sup> HMC3 cell model
Online Access:https://www.mdpi.com/1422-0067/24/3/2642

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