Defining obesity hypoventilation syndrome
With increasing prevalence of obesity, the substantial contribution of obesity hypoventilation syndrome (OHS) to morbidity and mortality is likely to increase. It is therefore crucial that the condition has a clear definition to allow timely identification of patients. OHS was first described as “Pi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2021-09-01
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| Series: | Breathe |
| Online Access: | http://breathe.ersjournals.com/content/17/3/210089.full |
| _version_ | 1818569358057668608 |
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| author | Neeraj M. Shah Sonia Shrimanker Georgios Kaltsakas |
| author_facet | Neeraj M. Shah Sonia Shrimanker Georgios Kaltsakas |
| author_sort | Neeraj M. Shah |
| collection | DOAJ |
| description | With increasing prevalence of obesity, the substantial contribution of obesity hypoventilation syndrome (OHS) to morbidity and mortality is likely to increase. It is therefore crucial that the condition has a clear definition to allow timely identification of patients. OHS was first described as “Pickwickian syndrome” in the 1950s; in subsequent decades, case reports did not clearly delineate between patients suffering from OHS and those suffering from obstructive sleep apnoea. In 1999, the American Academy of Sleep Medicine published a guideline that delineated the cause of daytime hypercapnia as either predominantly upper airway or predominantly hypoventilation. This was the first formal definition of OHS as the presence of daytime alveolar hypoventilation (arterial carbon dioxide tension >45 mmHg) in patients with body mass index >30 kg·m−2 in the absence of other causes of hypoventilation. This definition is reflected in the most recent guidelines published on OHS. Recent developments in defining OHS include proposed classification systems of severity and demonstrating the value of using serum bicarbonate to exclude OHS in patients with a low index of suspicion.
Educational aims
To provide an overview of the historical basis of the definition of obesity hypoventilation syndrome. To explain the rationale for the current definition of obesity hypoventilation syndrome. To demonstrate areas that need further investigation in defining obesity hypoventilation syndrome. |
| first_indexed | 2024-12-14T06:47:05Z |
| format | Article |
| id | doaj.art-3a91502560e746db9b16b78829f742bd |
| institution | Directory Open Access Journal |
| issn | 1810-6838 2073-4735 |
| language | English |
| last_indexed | 2024-12-14T06:47:05Z |
| publishDate | 2021-09-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | Breathe |
| spelling | doaj.art-3a91502560e746db9b16b78829f742bd2022-12-21T23:13:00ZengEuropean Respiratory SocietyBreathe1810-68382073-47352021-09-0117310.1183/20734735.0089-20210089-2021Defining obesity hypoventilation syndromeNeeraj M. Shah0Sonia Shrimanker1Georgios Kaltsakas2 Lane Fox Respiratory Service, St Thomas’ Hospital, Guy's and St Thomas’ NHS Foundation Trust, London, UK Lane Fox Respiratory Service, St Thomas’ Hospital, Guy's and St Thomas’ NHS Foundation Trust, London, UK Lane Fox Respiratory Service, St Thomas’ Hospital, Guy's and St Thomas’ NHS Foundation Trust, London, UK With increasing prevalence of obesity, the substantial contribution of obesity hypoventilation syndrome (OHS) to morbidity and mortality is likely to increase. It is therefore crucial that the condition has a clear definition to allow timely identification of patients. OHS was first described as “Pickwickian syndrome” in the 1950s; in subsequent decades, case reports did not clearly delineate between patients suffering from OHS and those suffering from obstructive sleep apnoea. In 1999, the American Academy of Sleep Medicine published a guideline that delineated the cause of daytime hypercapnia as either predominantly upper airway or predominantly hypoventilation. This was the first formal definition of OHS as the presence of daytime alveolar hypoventilation (arterial carbon dioxide tension >45 mmHg) in patients with body mass index >30 kg·m−2 in the absence of other causes of hypoventilation. This definition is reflected in the most recent guidelines published on OHS. Recent developments in defining OHS include proposed classification systems of severity and demonstrating the value of using serum bicarbonate to exclude OHS in patients with a low index of suspicion. Educational aims To provide an overview of the historical basis of the definition of obesity hypoventilation syndrome. To explain the rationale for the current definition of obesity hypoventilation syndrome. To demonstrate areas that need further investigation in defining obesity hypoventilation syndrome.http://breathe.ersjournals.com/content/17/3/210089.full |
| spellingShingle | Neeraj M. Shah Sonia Shrimanker Georgios Kaltsakas Defining obesity hypoventilation syndrome Breathe |
| title | Defining obesity hypoventilation syndrome |
| title_full | Defining obesity hypoventilation syndrome |
| title_fullStr | Defining obesity hypoventilation syndrome |
| title_full_unstemmed | Defining obesity hypoventilation syndrome |
| title_short | Defining obesity hypoventilation syndrome |
| title_sort | defining obesity hypoventilation syndrome |
| url | http://breathe.ersjournals.com/content/17/3/210089.full |
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