Early‐Life Famine Exposure and Risk of Cardiovascular Diseases in Later Life: Findings From the REACTION Study
Background Previous studies reported that early‐life exposure to undernutrition is associated with the risk of diabetes mellitus and metabolic syndrome in adulthood, but the association with risk of cardiovascular disease (CVD) later in life remains unclear. The current study aimed to investigate wh...
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| Format: | Article |
| Language: | English |
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Wiley
2020-04-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.119.014175 |
| _version_ | 1811332068105256960 |
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| author | Rui Du Ruizhi Zheng Yu Xu Yuanyue Zhu Xuefeng Yu Mian Li Xulei Tang Ruying Hu Qing Su Tiange Wang Zhiyun Zhao Min Xu Yuhong Chen Lixin Shi Qin Wan Gang Chen Meng Dai Di Zhang Zhengnan Gao Guixia Wang Feixia Shen Zuojie Luo Yingfen Qin Li Chen Yanan Huo Qiang Li Zhen Ye Yinfei Zhang Chao Liu Youmin Wang Shengli Wu Tao Yang Huacong Deng Lulu Chen Jiajun Zhao Yiming Mu Donghui Li Guijun Qin Weiqing Wang Guang Ning Li Yan Yufang Bi Jieli Lu |
| author_facet | Rui Du Ruizhi Zheng Yu Xu Yuanyue Zhu Xuefeng Yu Mian Li Xulei Tang Ruying Hu Qing Su Tiange Wang Zhiyun Zhao Min Xu Yuhong Chen Lixin Shi Qin Wan Gang Chen Meng Dai Di Zhang Zhengnan Gao Guixia Wang Feixia Shen Zuojie Luo Yingfen Qin Li Chen Yanan Huo Qiang Li Zhen Ye Yinfei Zhang Chao Liu Youmin Wang Shengli Wu Tao Yang Huacong Deng Lulu Chen Jiajun Zhao Yiming Mu Donghui Li Guijun Qin Weiqing Wang Guang Ning Li Yan Yufang Bi Jieli Lu |
| author_sort | Rui Du |
| collection | DOAJ |
| description | Background Previous studies reported that early‐life exposure to undernutrition is associated with the risk of diabetes mellitus and metabolic syndrome in adulthood, but the association with risk of cardiovascular disease (CVD) later in life remains unclear. The current study aimed to investigate whether exposure to Chinese famine in early life is associated with risk of CVD. Methods and Results We used data from REACTION (Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal Study), which recruited a total of 259 657 community‐dwelling adults aged 40 years or older from 25 centers across mainland China between 2011 and 2012. Compared with the nonexposed participants, those who had been exposed to famine in early life had a significantly increased risk of total CVD, myocardial infarction, stroke, and coronary heart disease. In the multivariable‐adjusted logistic regression model, the odds ratios (95% CI) for total CVD, myocardial infarction, stroke, and coronary heart disease in fetal famine exposure were 1.35 (1.20–1.52), 1.59 (1.08–2.35), 1.40 (1.11–1.78), and 1.44 (1.26–1.65), respectively; those odds ratios in childhood famine exposure were 1.59 (1.40–1.81), 2.20 (1.52–3.20), 1.82 (1.45–2.28), and 1.80 (1.56–2.09), respectively; and those in adolescent famine exposure were 1.52 (1.27–1.81), 2.07 (1.28–3.35), 1.92 (1.42–2.58), and 1.83 (1.50–2.24), respectively. The main finding of our study is that, compared with those who lived in the less severely affected famine area, individuals in the severely affected famine area had significantly increased risk of total CVD in all 3 exposed groups. Conclusions Early‐life exposure to undernutrition is associated with significantly increased risk of CVD in later life, especially among those who were in the severely affected famine area. |
| first_indexed | 2024-04-13T16:31:12Z |
| format | Article |
| id | doaj.art-3a9478ee602b45b088a763bda64d83fa |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-13T16:31:12Z |
| publishDate | 2020-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-3a9478ee602b45b088a763bda64d83fa2022-12-22T02:39:34ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802020-04-019710.1161/JAHA.119.014175Early‐Life Famine Exposure and Risk of Cardiovascular Diseases in Later Life: Findings From the REACTION StudyRui Du0Ruizhi Zheng1Yu Xu2Yuanyue Zhu3Xuefeng Yu4Mian Li5Xulei Tang6Ruying Hu7Qing Su8Tiange Wang9Zhiyun Zhao10Min Xu11Yuhong Chen12Lixin Shi13Qin Wan14Gang Chen15Meng Dai16Di Zhang17Zhengnan Gao18Guixia Wang19Feixia Shen20Zuojie Luo21Yingfen Qin22Li Chen23Yanan Huo24Qiang Li25Zhen Ye26Yinfei Zhang27Chao Liu28Youmin Wang29Shengli Wu30Tao Yang31Huacong Deng32Lulu Chen33Jiajun Zhao34Yiming Mu35Donghui Li36Guijun Qin37Weiqing Wang38Guang Ning39Li Yan40Yufang Bi41Jieli Lu42State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai ChinaState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai ChinaState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai ChinaState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai ChinaTongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai ChinaThe First Hospital of Lanzhou University Lanzhou ChinaZhejiang Provincial Center for Disease Control and Prevention Hangzhou ChinaXinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai ChinaState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai ChinaState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai ChinaState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai ChinaState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai ChinaAffiliated Hospital of Guiyang Medical College Guiyang ChinaThe Affiliated Hospital of Luzhou Medical College Luzhou ChinaFujian Provincial Hospital Fujian Medical University Fuzhou ChinaState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai ChinaState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai ChinaDalian Municipal Central Hospital Dalian ChinaThe First Hospital of Jilin University Changchun ChinaThe First Affiliated Hospital of Wenzhou Medical University Wenzhou ChinaThe First Affiliated Hospital of Guangxi Medical University Nanning ChinaThe First Affiliated Hospital of Guangxi Medical University Nanning ChinaQilu Hospital of Shandong University Jinan ChinaJiangxi Provincial People’s Hospital Affiliated to Nanchang University Nanchang ChinaThe Second Affiliated Hospital of Harbin Medical University Harbin ChinaZhejiang Provincial Center for Disease Control and Prevention Hangzhou ChinaCentral Hospital of Shanghai Jiading District Shanghai ChinaJiangsu Province Hospital on Integration of Chinese and Western Medicine Nanjing ChinaThe First Affiliated Hospital of Anhui Medical University Hefei ChinaKaramay Municipal People’s Hospital Xinjiang ChinaThe First Affiliated Hospital of Nanjing Medical University Nanjing ChinaThe First Affiliated Hospital of Chongqing Medical University Chongqing ChinaUnion Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaShandong Provincial Hospital affiliated to Shandong University Jinan ChinaChinese People’s Liberation Army General Hospital Beijing ChinaDepartment of Gastrointestinal Medical Oncology The University of Texas MD Anderson Cancer Center Houston TXThe First Affiliated Hospital of Zhengzhou University Zhengzhou ChinaState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai ChinaState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai ChinaSun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou ChinaState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai ChinaState Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai ChinaBackground Previous studies reported that early‐life exposure to undernutrition is associated with the risk of diabetes mellitus and metabolic syndrome in adulthood, but the association with risk of cardiovascular disease (CVD) later in life remains unclear. The current study aimed to investigate whether exposure to Chinese famine in early life is associated with risk of CVD. Methods and Results We used data from REACTION (Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal Study), which recruited a total of 259 657 community‐dwelling adults aged 40 years or older from 25 centers across mainland China between 2011 and 2012. Compared with the nonexposed participants, those who had been exposed to famine in early life had a significantly increased risk of total CVD, myocardial infarction, stroke, and coronary heart disease. In the multivariable‐adjusted logistic regression model, the odds ratios (95% CI) for total CVD, myocardial infarction, stroke, and coronary heart disease in fetal famine exposure were 1.35 (1.20–1.52), 1.59 (1.08–2.35), 1.40 (1.11–1.78), and 1.44 (1.26–1.65), respectively; those odds ratios in childhood famine exposure were 1.59 (1.40–1.81), 2.20 (1.52–3.20), 1.82 (1.45–2.28), and 1.80 (1.56–2.09), respectively; and those in adolescent famine exposure were 1.52 (1.27–1.81), 2.07 (1.28–3.35), 1.92 (1.42–2.58), and 1.83 (1.50–2.24), respectively. The main finding of our study is that, compared with those who lived in the less severely affected famine area, individuals in the severely affected famine area had significantly increased risk of total CVD in all 3 exposed groups. Conclusions Early‐life exposure to undernutrition is associated with significantly increased risk of CVD in later life, especially among those who were in the severely affected famine area.https://www.ahajournals.org/doi/10.1161/JAHA.119.014175associationcardiovascular diseasesearly‐life exposurefamine |
| spellingShingle | Rui Du Ruizhi Zheng Yu Xu Yuanyue Zhu Xuefeng Yu Mian Li Xulei Tang Ruying Hu Qing Su Tiange Wang Zhiyun Zhao Min Xu Yuhong Chen Lixin Shi Qin Wan Gang Chen Meng Dai Di Zhang Zhengnan Gao Guixia Wang Feixia Shen Zuojie Luo Yingfen Qin Li Chen Yanan Huo Qiang Li Zhen Ye Yinfei Zhang Chao Liu Youmin Wang Shengli Wu Tao Yang Huacong Deng Lulu Chen Jiajun Zhao Yiming Mu Donghui Li Guijun Qin Weiqing Wang Guang Ning Li Yan Yufang Bi Jieli Lu Early‐Life Famine Exposure and Risk of Cardiovascular Diseases in Later Life: Findings From the REACTION Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease association cardiovascular diseases early‐life exposure famine |
| title | Early‐Life Famine Exposure and Risk of Cardiovascular Diseases in Later Life: Findings From the REACTION Study |
| title_full | Early‐Life Famine Exposure and Risk of Cardiovascular Diseases in Later Life: Findings From the REACTION Study |
| title_fullStr | Early‐Life Famine Exposure and Risk of Cardiovascular Diseases in Later Life: Findings From the REACTION Study |
| title_full_unstemmed | Early‐Life Famine Exposure and Risk of Cardiovascular Diseases in Later Life: Findings From the REACTION Study |
| title_short | Early‐Life Famine Exposure and Risk of Cardiovascular Diseases in Later Life: Findings From the REACTION Study |
| title_sort | early life famine exposure and risk of cardiovascular diseases in later life findings from the reaction study |
| topic | association cardiovascular diseases early‐life exposure famine |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.119.014175 |
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