The impact of repeated marathon running on cardiovascular function in the aging population
<p>Abstract</p> <p>Background</p> <p>Several studies have correlated elevations in cardiac biomarkers of injury post marathon with transient and reversible right ventricular (RV) systolic dysfunction as assessed by both transthoracic echocardiography (TTE) and cardiovas...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2012-08-01
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| Series: | Journal of Cardiovascular Magnetic Resonance |
| Subjects: | |
| Online Access: | http://www.jcmr-online.com/content/14/1/58 |
| _version_ | 1827279380055851008 |
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| author | Karlstedt Erin Chelvanathan Anjala Da Silva Megan Cleverley Kelby Kumar Kanwal Bhullar Navdeep Lytwyn Matthew Bohonis Sheena Oomah Sacha Nepomuceno Roman Du Xiaozhou Melnyk Steven Zeglinski Matthew Ducas Robin Sefidgar Mehdi Mackenzie Scott Sharma Sat Kirkpatrick Iain D Jassal Davinder S |
| author_facet | Karlstedt Erin Chelvanathan Anjala Da Silva Megan Cleverley Kelby Kumar Kanwal Bhullar Navdeep Lytwyn Matthew Bohonis Sheena Oomah Sacha Nepomuceno Roman Du Xiaozhou Melnyk Steven Zeglinski Matthew Ducas Robin Sefidgar Mehdi Mackenzie Scott Sharma Sat Kirkpatrick Iain D Jassal Davinder S |
| author_sort | Karlstedt Erin |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Several studies have correlated elevations in cardiac biomarkers of injury post marathon with transient and reversible right ventricular (RV) systolic dysfunction as assessed by both transthoracic echocardiography (TTE) and cardiovascular magnetic resonance (CMR). Whether or not permanent myocardial injury occurs due to repeated marathon running in the aging population remains controversial.</p> <p>Objectives</p> <p>To assess the extent and severity of cardiac dysfunction after the completion of full marathon running in individuals greater than 50 years of age using cardiac biomarkers, TTE, cardiac computed tomography (CCT), and CMR.</p> <p>Methods</p> <p>A total of 25 healthy volunteers (21 males, 55 ± 4 years old) from the 2010 and 2011 Manitoba Full Marathons (26.2 miles) were included in the study. Cardiac biomarkers and TTE were performed one week prior to the marathon, immediately after completing the race and at one-week follow-up. CMR was performed at baseline and within 24 hours of completion of the marathon, followed by CCT within 3 months of the marathon.</p> <p>Results</p> <p>All participants demonstrated an elevated cTnT post marathon. Right atrial and ventricular volumes increased, while RV systolic function decreased significantly immediately post marathon, returning to baseline values one week later. Of the entire study population, only two individuals demonstrated late gadolinium enhancement of the subendocardium in the anterior wall of the left ventricle, with evidence of stenosis of the left anterior descending artery on CCT.</p> <p>Conclusions</p> <p>Marathon running in individuals over the age of 50 is associated with a transient, yet reversible increase in cardiac biomarkers and RV systolic dysfunction. The presence of myocardial fibrosis in older marathon athletes is infrequent, but when present, may be due to underlying occult coronary artery disease.</p> |
| first_indexed | 2024-04-24T08:18:00Z |
| format | Article |
| id | doaj.art-3a94b5e4566542bc9fe68e5079ffc2d7 |
| institution | Directory Open Access Journal |
| issn | 1097-6647 1532-429X |
| language | English |
| last_indexed | 2024-04-24T08:18:00Z |
| publishDate | 2012-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj.art-3a94b5e4566542bc9fe68e5079ffc2d72024-04-17T02:30:12ZengElsevierJournal of Cardiovascular Magnetic Resonance1097-66471532-429X2012-08-011415810.1186/1532-429X-14-58The impact of repeated marathon running on cardiovascular function in the aging populationKarlstedt ErinChelvanathan AnjalaDa Silva MeganCleverley KelbyKumar KanwalBhullar NavdeepLytwyn MatthewBohonis SheenaOomah SachaNepomuceno RomanDu XiaozhouMelnyk StevenZeglinski MatthewDucas RobinSefidgar MehdiMackenzie ScottSharma SatKirkpatrick Iain DJassal Davinder S<p>Abstract</p> <p>Background</p> <p>Several studies have correlated elevations in cardiac biomarkers of injury post marathon with transient and reversible right ventricular (RV) systolic dysfunction as assessed by both transthoracic echocardiography (TTE) and cardiovascular magnetic resonance (CMR). Whether or not permanent myocardial injury occurs due to repeated marathon running in the aging population remains controversial.</p> <p>Objectives</p> <p>To assess the extent and severity of cardiac dysfunction after the completion of full marathon running in individuals greater than 50 years of age using cardiac biomarkers, TTE, cardiac computed tomography (CCT), and CMR.</p> <p>Methods</p> <p>A total of 25 healthy volunteers (21 males, 55 ± 4 years old) from the 2010 and 2011 Manitoba Full Marathons (26.2 miles) were included in the study. Cardiac biomarkers and TTE were performed one week prior to the marathon, immediately after completing the race and at one-week follow-up. CMR was performed at baseline and within 24 hours of completion of the marathon, followed by CCT within 3 months of the marathon.</p> <p>Results</p> <p>All participants demonstrated an elevated cTnT post marathon. Right atrial and ventricular volumes increased, while RV systolic function decreased significantly immediately post marathon, returning to baseline values one week later. Of the entire study population, only two individuals demonstrated late gadolinium enhancement of the subendocardium in the anterior wall of the left ventricle, with evidence of stenosis of the left anterior descending artery on CCT.</p> <p>Conclusions</p> <p>Marathon running in individuals over the age of 50 is associated with a transient, yet reversible increase in cardiac biomarkers and RV systolic dysfunction. The presence of myocardial fibrosis in older marathon athletes is infrequent, but when present, may be due to underlying occult coronary artery disease.</p>http://www.jcmr-online.com/content/14/1/58Marathon runningCardiac biomarkersEchocardiographyCardiac computed tomographyCardiovascular magnetic resonance |
| spellingShingle | Karlstedt Erin Chelvanathan Anjala Da Silva Megan Cleverley Kelby Kumar Kanwal Bhullar Navdeep Lytwyn Matthew Bohonis Sheena Oomah Sacha Nepomuceno Roman Du Xiaozhou Melnyk Steven Zeglinski Matthew Ducas Robin Sefidgar Mehdi Mackenzie Scott Sharma Sat Kirkpatrick Iain D Jassal Davinder S The impact of repeated marathon running on cardiovascular function in the aging population Journal of Cardiovascular Magnetic Resonance Marathon running Cardiac biomarkers Echocardiography Cardiac computed tomography Cardiovascular magnetic resonance |
| title | The impact of repeated marathon running on cardiovascular function in the aging population |
| title_full | The impact of repeated marathon running on cardiovascular function in the aging population |
| title_fullStr | The impact of repeated marathon running on cardiovascular function in the aging population |
| title_full_unstemmed | The impact of repeated marathon running on cardiovascular function in the aging population |
| title_short | The impact of repeated marathon running on cardiovascular function in the aging population |
| title_sort | impact of repeated marathon running on cardiovascular function in the aging population |
| topic | Marathon running Cardiac biomarkers Echocardiography Cardiac computed tomography Cardiovascular magnetic resonance |
| url | http://www.jcmr-online.com/content/14/1/58 |
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