Catalytic anti-oxidative stress for osteoarthritis treatment by few-layered phosphorene
As one of the most common representations of articular cartilage damage, osteoarthritis (OA) is characterized by the apoptosis and dysfunction of chondrocytes as well as the progressive degradation of extracellular matrix, of which the main components are glycosaminoglycan and type Ⅱ collagen. Few-l...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006422002605 |
| _version_ | 1797989753569673216 |
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| author | Xingyu Zhang Yanling You Yaying Sun Xiang Guo Han Lin Ming Zong Jianlin Shi |
| author_facet | Xingyu Zhang Yanling You Yaying Sun Xiang Guo Han Lin Ming Zong Jianlin Shi |
| author_sort | Xingyu Zhang |
| collection | DOAJ |
| description | As one of the most common representations of articular cartilage damage, osteoarthritis (OA) is characterized by the apoptosis and dysfunction of chondrocytes as well as the progressive degradation of extracellular matrix, of which the main components are glycosaminoglycan and type Ⅱ collagen. Few-layered phosphorene (FLP) has been attracting great attentions in biomedical fields owing to the excellent capability of in-situ catalysis for scavenging oxidate-associated molecules, especially the reactive oxygen species (ROS) and reactive nitrogen species (RNS). Herein, FLP has been fabricated and employed for articular cartilage protection by means of deleting oxidate-associated molecules. The in vitro results show that as low as 200 μg/mL FLP is capable of diminishing oxidative damages on the osteoarthritic chondrocytes through the efficient elimination of ROS, H2O2 and NO. Meanwhile, the cartilage matrix protection has also been achieved at 200 μg/mL FLP by the uniform restoration of glycosaminoglycan and type Ⅱ collagen. FLP enables the nanocatalytic treatment for the overloaded oxidative stress in the injured articular cartilage and represents a promising alternative for osteoarthritis therapy. |
| first_indexed | 2024-04-11T08:24:27Z |
| format | Article |
| id | doaj.art-3a985d9726fa46a6990829d7b63070ad |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-04-11T08:24:27Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-3a985d9726fa46a6990829d7b63070ad2022-12-22T04:34:48ZengElsevierMaterials Today Bio2590-00642022-12-0117100462Catalytic anti-oxidative stress for osteoarthritis treatment by few-layered phosphoreneXingyu Zhang0Yanling You1Yaying Sun2Xiang Guo3 Han Lin4Ming Zong5Jianlin Shi6Department of Sports Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, PR ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences, Shanghai, 200050, PR ChinaDepartment of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, PR ChinaDepartment of Orthopedics, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, PR China; Corresponding author.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences, Shanghai, 200050, PR China; Corresponding author.Department of Clinical Laboratory, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, PR China; Corresponding author.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences, Shanghai, 200050, PR ChinaAs one of the most common representations of articular cartilage damage, osteoarthritis (OA) is characterized by the apoptosis and dysfunction of chondrocytes as well as the progressive degradation of extracellular matrix, of which the main components are glycosaminoglycan and type Ⅱ collagen. Few-layered phosphorene (FLP) has been attracting great attentions in biomedical fields owing to the excellent capability of in-situ catalysis for scavenging oxidate-associated molecules, especially the reactive oxygen species (ROS) and reactive nitrogen species (RNS). Herein, FLP has been fabricated and employed for articular cartilage protection by means of deleting oxidate-associated molecules. The in vitro results show that as low as 200 μg/mL FLP is capable of diminishing oxidative damages on the osteoarthritic chondrocytes through the efficient elimination of ROS, H2O2 and NO. Meanwhile, the cartilage matrix protection has also been achieved at 200 μg/mL FLP by the uniform restoration of glycosaminoglycan and type Ⅱ collagen. FLP enables the nanocatalytic treatment for the overloaded oxidative stress in the injured articular cartilage and represents a promising alternative for osteoarthritis therapy.http://www.sciencedirect.com/science/article/pii/S2590006422002605PhosphoreneIn-situ catalysisAnti-inflammatoryOsteoarthritisNanocatalytic medicine |
| spellingShingle | Xingyu Zhang Yanling You Yaying Sun Xiang Guo Han Lin Ming Zong Jianlin Shi Catalytic anti-oxidative stress for osteoarthritis treatment by few-layered phosphorene Materials Today Bio Phosphorene In-situ catalysis Anti-inflammatory Osteoarthritis Nanocatalytic medicine |
| title | Catalytic anti-oxidative stress for osteoarthritis treatment by few-layered phosphorene |
| title_full | Catalytic anti-oxidative stress for osteoarthritis treatment by few-layered phosphorene |
| title_fullStr | Catalytic anti-oxidative stress for osteoarthritis treatment by few-layered phosphorene |
| title_full_unstemmed | Catalytic anti-oxidative stress for osteoarthritis treatment by few-layered phosphorene |
| title_short | Catalytic anti-oxidative stress for osteoarthritis treatment by few-layered phosphorene |
| title_sort | catalytic anti oxidative stress for osteoarthritis treatment by few layered phosphorene |
| topic | Phosphorene In-situ catalysis Anti-inflammatory Osteoarthritis Nanocatalytic medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2590006422002605 |
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