Pro-inflammatory genetic profile and familiarity of acute myocardial infarction
<p>Abstract</p> <p>Background</p> <p>Acute myocardial infarction (AMI) is a multifactorial disease with a complex pathogenesis where lifestyle, individual genetic background and environmental risk factors are involved. Altered inflammatory responses are implicated in th...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-06-01
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| Series: | Immunity & Ageing |
| Subjects: | |
| Online Access: | http://www.immunityageing.com/content/9/1/14 |
| _version_ | 1811318114149728256 |
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| author | Ianni Manuela Callegari Sergio Rizzo Antonio Pastori Paolo Moruzzi Paolo Corradi Domenico Porcellini Elisa Campo Gianluca Ferrari Roberto Ferrario Marco M Bitonte Stefania Carbone Ilaria Licastro Federico |
| author_facet | Ianni Manuela Callegari Sergio Rizzo Antonio Pastori Paolo Moruzzi Paolo Corradi Domenico Porcellini Elisa Campo Gianluca Ferrari Roberto Ferrario Marco M Bitonte Stefania Carbone Ilaria Licastro Federico |
| author_sort | Ianni Manuela |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Acute myocardial infarction (AMI) is a multifactorial disease with a complex pathogenesis where lifestyle, individual genetic background and environmental risk factors are involved. Altered inflammatory responses are implicated in the pathogenesis of atherosclerosis and a premature AMI of parents is associated with an increased risk of the disease in their offspring (Offs). However, the genetic background of familiarity for AMI is still largely unknown. To understand which genes may predispose to increased risk of cardiovascular disease gene polymorphism of immune regulatory genes, and clinical events from the Offs of parents with an early AMI were investigated. Genetics data from Offs were compared with those obtained from healthy subjects and an independent cohort of patients with clinical sporadic AMI. Rates of clinical events during a 24 years follow up from Offs and from an independent Italian population survey were also evaluated.</p> <p>Results</p> <p>This study showed that a genetic signature consisting of the concomitant presence of the CC genotype of VEGF, the A allele of IL-10 and the A allele of IFN-γ was indeed present in the Offs population. In fact, the above genetic markers were more frequent in unaffected Offs (46.4%) and patients with sporadic AMI (31.8%) than in the CTR (17.3%) and the differences were highly statistically significant (Offs vs CTR: p = 0.0001, OR = 4.129; AMI vs CTR: p = 0.0001, OR = 2.224). During the 24-year follow-up, Offs with a positive familiarity in spite of a relatively young age showed an increased prevalence of diabetes, ischemic heart disease and stroke. These findings reinforce the notion that subjects with a familial history of AMI are at risk of an accelerated aging of cardiovascular system resulting in cardiovascular events.</p> <p>Conclusion</p> <p>Our data suggest that selected genes with immune regulatory functions are part of the complex genetic background contributing to familiarity for cardiovascular diseases. This inflammatory genetic profile, along with classical cardiovascular risk factors, may be used for better defining individual risk of AMI in unaffected subjects.</p> |
| first_indexed | 2024-04-13T12:20:22Z |
| format | Article |
| id | doaj.art-3a9a27bbef0c47df9b6cdf9db4e90b11 |
| institution | Directory Open Access Journal |
| issn | 1742-4933 |
| language | English |
| last_indexed | 2024-04-13T12:20:22Z |
| publishDate | 2012-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Immunity & Ageing |
| spelling | doaj.art-3a9a27bbef0c47df9b6cdf9db4e90b112022-12-22T02:47:13ZengBMCImmunity & Ageing1742-49332012-06-01911410.1186/1742-4933-9-14Pro-inflammatory genetic profile and familiarity of acute myocardial infarctionIanni ManuelaCallegari SergioRizzo AntonioPastori PaoloMoruzzi PaoloCorradi DomenicoPorcellini ElisaCampo GianlucaFerrari RobertoFerrario Marco MBitonte StefaniaCarbone IlariaLicastro Federico<p>Abstract</p> <p>Background</p> <p>Acute myocardial infarction (AMI) is a multifactorial disease with a complex pathogenesis where lifestyle, individual genetic background and environmental risk factors are involved. Altered inflammatory responses are implicated in the pathogenesis of atherosclerosis and a premature AMI of parents is associated with an increased risk of the disease in their offspring (Offs). However, the genetic background of familiarity for AMI is still largely unknown. To understand which genes may predispose to increased risk of cardiovascular disease gene polymorphism of immune regulatory genes, and clinical events from the Offs of parents with an early AMI were investigated. Genetics data from Offs were compared with those obtained from healthy subjects and an independent cohort of patients with clinical sporadic AMI. Rates of clinical events during a 24 years follow up from Offs and from an independent Italian population survey were also evaluated.</p> <p>Results</p> <p>This study showed that a genetic signature consisting of the concomitant presence of the CC genotype of VEGF, the A allele of IL-10 and the A allele of IFN-γ was indeed present in the Offs population. In fact, the above genetic markers were more frequent in unaffected Offs (46.4%) and patients with sporadic AMI (31.8%) than in the CTR (17.3%) and the differences were highly statistically significant (Offs vs CTR: p = 0.0001, OR = 4.129; AMI vs CTR: p = 0.0001, OR = 2.224). During the 24-year follow-up, Offs with a positive familiarity in spite of a relatively young age showed an increased prevalence of diabetes, ischemic heart disease and stroke. These findings reinforce the notion that subjects with a familial history of AMI are at risk of an accelerated aging of cardiovascular system resulting in cardiovascular events.</p> <p>Conclusion</p> <p>Our data suggest that selected genes with immune regulatory functions are part of the complex genetic background contributing to familiarity for cardiovascular diseases. This inflammatory genetic profile, along with classical cardiovascular risk factors, may be used for better defining individual risk of AMI in unaffected subjects.</p>http://www.immunityageing.com/content/9/1/14Acute myocardial infarctionFamily historyGenetic associationInflammation |
| spellingShingle | Ianni Manuela Callegari Sergio Rizzo Antonio Pastori Paolo Moruzzi Paolo Corradi Domenico Porcellini Elisa Campo Gianluca Ferrari Roberto Ferrario Marco M Bitonte Stefania Carbone Ilaria Licastro Federico Pro-inflammatory genetic profile and familiarity of acute myocardial infarction Immunity & Ageing Acute myocardial infarction Family history Genetic association Inflammation |
| title | Pro-inflammatory genetic profile and familiarity of acute myocardial infarction |
| title_full | Pro-inflammatory genetic profile and familiarity of acute myocardial infarction |
| title_fullStr | Pro-inflammatory genetic profile and familiarity of acute myocardial infarction |
| title_full_unstemmed | Pro-inflammatory genetic profile and familiarity of acute myocardial infarction |
| title_short | Pro-inflammatory genetic profile and familiarity of acute myocardial infarction |
| title_sort | pro inflammatory genetic profile and familiarity of acute myocardial infarction |
| topic | Acute myocardial infarction Family history Genetic association Inflammation |
| url | http://www.immunityageing.com/content/9/1/14 |
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