Predicting the effect of different folate doses on [68Ga]Ga-PSMA-11 organ and tumor uptake using physiologically based pharmacokinetic modeling

Predicting the effect of different folate doses on [68Ga]Ga-PSMA-11 organ and tumor uptake using physiologically based pharmacokinetic modeling

Abstract Background Folate intake might reduce [68Ga]Ga-PSMA-11 uptake in tissues due to a competitive binding to the PSMA receptor. For diagnostic imaging, this could impact decision making, while during radioligand therapy this could affect treatment efficacy. The relationship between folate dose,...

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Bibliographic Details
Main Authors: Hinke Siebinga, Jeroen J. M. A. Hendrikx, Alwin D. R. Huitema, Berlinda J. de Wit-van der Veen
Format: Article
Language:English
Published: SpringerOpen 2023-06-01
Series:EJNMMI Research
Subjects:
[68Ga]Ga-PSMA-11
Folate
Folic acid
PSMA
PBPK model
Online Access:https://doi.org/10.1186/s13550-023-01008-y

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