Diacerein Loaded Novasome for Transdermal Delivery: Prepartion , In-Vitro Characterization and Factors Affecting Formulation
Diacerein (DCN) is a semi-synthetic anthraquinone derivative of Rhein that is indicated for the management of osteoarthritis. Diacerein exhibits poor dissolution in the GIT fluids and suffers from low bioavailability upon oral administration in addition to the laxative effect of Rhein metabolites....
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| Format: | Article |
| Language: | English |
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College of Pharmacy University of Baghdad
2023-11-01
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| Series: | Iraqi Journal of Pharmaceutical Sciences |
| Online Access: | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/2597 |
| _version_ | 1797635802030669824 |
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| author | Noor Yousif Albassam Hanan Jalal Kassab |
| author_facet | Noor Yousif Albassam Hanan Jalal Kassab |
| author_sort | Noor Yousif Albassam |
| collection | DOAJ |
| description |
Diacerein (DCN) is a semi-synthetic anthraquinone derivative of Rhein that is indicated for the management of osteoarthritis. Diacerein exhibits poor dissolution in the GIT fluids and suffers from low bioavailability upon oral administration in addition to the laxative effect of Rhein metabolites. The aim of the present study was to develop novasomal vesicles with optimized entrapment efficiency and size to serve as a carrier for transdermal delivery of diacerein. Novasomal vesicles were prepared by thin film hydration method thin film hydration. The prepared vesicles were optimized utilizing different surfactant to cholesterol molar ration, sonication type, different sonication times and varying fatty acid level. The prepared vesicles were characterized for drug entrapment efficiency, vesicle size and PDI. The best formula was further investigated for zeta potential ten TEM and compatibility study by FTIR analysis. Results showed that F6 was the best formula regarding it vesicle size 275.2± 2.68nm , entrapment efficiency 69.415± 0.234 % and PDI 0.309± 0.016. In conclusion , novasomal dispersion could be successfully formulated with thin film hydration method.
Keywords: Diacerein , Novasome , Transdermal Delivery ,Vesicular System .
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| first_indexed | 2024-03-11T12:26:32Z |
| format | Article |
| id | doaj.art-3aa026670476407998bcb4106e516d96 |
| institution | Directory Open Access Journal |
| issn | 1683-3597 2521-3512 |
| language | English |
| last_indexed | 2024-03-11T12:26:32Z |
| publishDate | 2023-11-01 |
| publisher | College of Pharmacy University of Baghdad |
| record_format | Article |
| series | Iraqi Journal of Pharmaceutical Sciences |
| spelling | doaj.art-3aa026670476407998bcb4106e516d962023-11-06T08:57:53ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences1683-35972521-35122023-11-0132Suppl.10.31351/vol32issSuppl.pp214-224Diacerein Loaded Novasome for Transdermal Delivery: Prepartion , In-Vitro Characterization and Factors Affecting Formulation Noor Yousif Albassam0Hanan Jalal Kassab11Department of Pharmaceutics, College of Pharmacy, University of Basrah, Basrah, Iraq.¬2Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq Diacerein (DCN) is a semi-synthetic anthraquinone derivative of Rhein that is indicated for the management of osteoarthritis. Diacerein exhibits poor dissolution in the GIT fluids and suffers from low bioavailability upon oral administration in addition to the laxative effect of Rhein metabolites. The aim of the present study was to develop novasomal vesicles with optimized entrapment efficiency and size to serve as a carrier for transdermal delivery of diacerein. Novasomal vesicles were prepared by thin film hydration method thin film hydration. The prepared vesicles were optimized utilizing different surfactant to cholesterol molar ration, sonication type, different sonication times and varying fatty acid level. The prepared vesicles were characterized for drug entrapment efficiency, vesicle size and PDI. The best formula was further investigated for zeta potential ten TEM and compatibility study by FTIR analysis. Results showed that F6 was the best formula regarding it vesicle size 275.2± 2.68nm , entrapment efficiency 69.415± 0.234 % and PDI 0.309± 0.016. In conclusion , novasomal dispersion could be successfully formulated with thin film hydration method. Keywords: Diacerein , Novasome , Transdermal Delivery ,Vesicular System . https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/2597 |
| spellingShingle | Noor Yousif Albassam Hanan Jalal Kassab Diacerein Loaded Novasome for Transdermal Delivery: Prepartion , In-Vitro Characterization and Factors Affecting Formulation Iraqi Journal of Pharmaceutical Sciences |
| title | Diacerein Loaded Novasome for Transdermal Delivery: Prepartion , In-Vitro Characterization and Factors Affecting Formulation |
| title_full | Diacerein Loaded Novasome for Transdermal Delivery: Prepartion , In-Vitro Characterization and Factors Affecting Formulation |
| title_fullStr | Diacerein Loaded Novasome for Transdermal Delivery: Prepartion , In-Vitro Characterization and Factors Affecting Formulation |
| title_full_unstemmed | Diacerein Loaded Novasome for Transdermal Delivery: Prepartion , In-Vitro Characterization and Factors Affecting Formulation |
| title_short | Diacerein Loaded Novasome for Transdermal Delivery: Prepartion , In-Vitro Characterization and Factors Affecting Formulation |
| title_sort | diacerein loaded novasome for transdermal delivery prepartion in vitro characterization and factors affecting formulation |
| url | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/2597 |
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