Rheology and Gelation of Hyaluronic Acid/Chitosan Coacervates
Hyaluronic acid (HA) and chitosan (CHI) are biopolyelectrolytes which are interesting for both the medical and polymer physics communities due to their biocompatibility and semi-flexibility, respectively. In this work, we demonstrate by rheology experiments that the linear viscoelasticity of HA/CHI...
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| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/12/1817 |
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| author | A. Basak Kayitmazer Fatih Comert Henning H. Winter Phillip B. Messersmith |
| author_facet | A. Basak Kayitmazer Fatih Comert Henning H. Winter Phillip B. Messersmith |
| author_sort | A. Basak Kayitmazer |
| collection | DOAJ |
| description | Hyaluronic acid (HA) and chitosan (CHI) are biopolyelectrolytes which are interesting for both the medical and polymer physics communities due to their biocompatibility and semi-flexibility, respectively. In this work, we demonstrate by rheology experiments that the linear viscoelasticity of HA/CHI coacervates depends strongly on the molecular weight of the polymers. Moduli for coacervates were found significantly higher than those of individual HA and CHI physical gels. A remarkable 1.5-fold increase in moduli was noted when catechol-conjugated HA and CHI were used instead. This was attributed to the conversion of coacervates to chemical gels by oxidation of 3,4-dihydroxyphenylalanine (DOPA) groups in HA and CHI to di-DOPA crosslinks. These rheological results put HA/CHI coacervates in the category of strong candidates as injectable tissue scaffolds or medical adhesives. |
| first_indexed | 2024-03-09T17:17:04Z |
| format | Article |
| id | doaj.art-3aa12c0ec90343319a0157775de4168b |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T17:17:04Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-3aa12c0ec90343319a0157775de4168b2023-11-24T13:33:51ZengMDPI AGBiomolecules2218-273X2022-12-011212181710.3390/biom12121817Rheology and Gelation of Hyaluronic Acid/Chitosan CoacervatesA. Basak Kayitmazer0Fatih Comert1Henning H. Winter2Phillip B. Messersmith3Department of Chemistry, Bogazici University, Istanbul 34342, TurkeyDepartment of Chemistry, Bogazici University, Istanbul 34342, TurkeyDepartment of Chemical Engineering, University of Massachusetts Amherst, Amherst, MA 01003, USADepartment of Bioengineering, University of California, Berkeley, CA 94720, USAHyaluronic acid (HA) and chitosan (CHI) are biopolyelectrolytes which are interesting for both the medical and polymer physics communities due to their biocompatibility and semi-flexibility, respectively. In this work, we demonstrate by rheology experiments that the linear viscoelasticity of HA/CHI coacervates depends strongly on the molecular weight of the polymers. Moduli for coacervates were found significantly higher than those of individual HA and CHI physical gels. A remarkable 1.5-fold increase in moduli was noted when catechol-conjugated HA and CHI were used instead. This was attributed to the conversion of coacervates to chemical gels by oxidation of 3,4-dihydroxyphenylalanine (DOPA) groups in HA and CHI to di-DOPA crosslinks. These rheological results put HA/CHI coacervates in the category of strong candidates as injectable tissue scaffolds or medical adhesives.https://www.mdpi.com/2218-273X/12/12/1817coacervationlinear viscoelasticityrheologycatecholDOPAhyaluronic acid |
| spellingShingle | A. Basak Kayitmazer Fatih Comert Henning H. Winter Phillip B. Messersmith Rheology and Gelation of Hyaluronic Acid/Chitosan Coacervates Biomolecules coacervation linear viscoelasticity rheology catechol DOPA hyaluronic acid |
| title | Rheology and Gelation of Hyaluronic Acid/Chitosan Coacervates |
| title_full | Rheology and Gelation of Hyaluronic Acid/Chitosan Coacervates |
| title_fullStr | Rheology and Gelation of Hyaluronic Acid/Chitosan Coacervates |
| title_full_unstemmed | Rheology and Gelation of Hyaluronic Acid/Chitosan Coacervates |
| title_short | Rheology and Gelation of Hyaluronic Acid/Chitosan Coacervates |
| title_sort | rheology and gelation of hyaluronic acid chitosan coacervates |
| topic | coacervation linear viscoelasticity rheology catechol DOPA hyaluronic acid |
| url | https://www.mdpi.com/2218-273X/12/12/1817 |
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