Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways
Over the past two decades, cancer stem cells (CSCs) have emerged as an immensely studied and experimental topic, however a wide range of questions concerning the topic still remain unanswered; in particular, the mechanisms underlying the regulation of tumor stem cells and their characteristics. Unde...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/21/3492 |
| _version_ | 1827646918451265536 |
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| author | Kevina Sonawala Satish Ramalingam Iyappan Sellamuthu |
| author_facet | Kevina Sonawala Satish Ramalingam Iyappan Sellamuthu |
| author_sort | Kevina Sonawala |
| collection | DOAJ |
| description | Over the past two decades, cancer stem cells (CSCs) have emerged as an immensely studied and experimental topic, however a wide range of questions concerning the topic still remain unanswered; in particular, the mechanisms underlying the regulation of tumor stem cells and their characteristics. Understanding the cancer stem-cell signaling pathways may pave the way towards a better comprehension of these mechanisms. Signaling pathways such as WNT, STAT, Hedgehog, NOTCH, PI3K/AKT/mTOR, TGF-β, and NF-κB are responsible not only for modulating various features of CSCs but also their microenvironments. Recently, the prominent roles of various non-coding RNAs such as small non-coding RNAs (sncRNAs) and long non-coding RNAs (lncRNAs) in developing and enhancing the tumor phenotypes have been unfolded. This review attempts to shed light on understanding the influence of long non- coding RNAs in the modulation of various CSC-signaling pathways and its impact on the CSCs and tumor properties; highlighting the protagonistic and antagonistic roles of lncRNAs. |
| first_indexed | 2024-03-09T19:11:11Z |
| format | Article |
| id | doaj.art-3aa16d600e4b49fc8e481a9f28f0e81f |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T19:11:11Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-3aa16d600e4b49fc8e481a9f28f0e81f2023-11-24T04:09:39ZengMDPI AGCells2073-44092022-11-011121349210.3390/cells11213492Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling PathwaysKevina Sonawala0Satish Ramalingam1Iyappan Sellamuthu2Department of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur, Chennai 603202, IndiaDepartment of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur, Chennai 603202, IndiaDepartment of Genetic Engineering, SRM Institute of Science and Technology, Kattankulathur, Chennai 603202, IndiaOver the past two decades, cancer stem cells (CSCs) have emerged as an immensely studied and experimental topic, however a wide range of questions concerning the topic still remain unanswered; in particular, the mechanisms underlying the regulation of tumor stem cells and their characteristics. Understanding the cancer stem-cell signaling pathways may pave the way towards a better comprehension of these mechanisms. Signaling pathways such as WNT, STAT, Hedgehog, NOTCH, PI3K/AKT/mTOR, TGF-β, and NF-κB are responsible not only for modulating various features of CSCs but also their microenvironments. Recently, the prominent roles of various non-coding RNAs such as small non-coding RNAs (sncRNAs) and long non-coding RNAs (lncRNAs) in developing and enhancing the tumor phenotypes have been unfolded. This review attempts to shed light on understanding the influence of long non- coding RNAs in the modulation of various CSC-signaling pathways and its impact on the CSCs and tumor properties; highlighting the protagonistic and antagonistic roles of lncRNAs.https://www.mdpi.com/2073-4409/11/21/3492non-coding RNAslncRNAscancer stem cellssignaling pathwaysCSC signaling pathways |
| spellingShingle | Kevina Sonawala Satish Ramalingam Iyappan Sellamuthu Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways Cells non-coding RNAs lncRNAs cancer stem cells signaling pathways CSC signaling pathways |
| title | Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways |
| title_full | Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways |
| title_fullStr | Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways |
| title_full_unstemmed | Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways |
| title_short | Influence of Long Non-Coding RNA in the Regulation of Cancer Stem Cell Signaling Pathways |
| title_sort | influence of long non coding rna in the regulation of cancer stem cell signaling pathways |
| topic | non-coding RNAs lncRNAs cancer stem cells signaling pathways CSC signaling pathways |
| url | https://www.mdpi.com/2073-4409/11/21/3492 |
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