Clozapine prescription trends in Brazil in the last decade
Objective: Clozapine is a second-generation antipsychotic indicated for treatment-resistant schizophrenia. Studies in several countries have shown a low rate of clozapine use despite the fact that approximately 30% of schizophrenia cases are treatment-resistant. In Brazil, few studies have addresse...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Psiquiatria (ABP)
2022-10-01
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| Series: | Brazilian Journal of Psychiatry |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462022005011204&tlng=en |
| _version_ | 1828142525861330944 |
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| author | Raffael Massuda Clarissa S. Gama Paulo Belmonte-de-Abreu Helio Elkis David Freitas de Lucena Rodrigo Bressan Cristiano Noto Ary Gadelha |
| author_facet | Raffael Massuda Clarissa S. Gama Paulo Belmonte-de-Abreu Helio Elkis David Freitas de Lucena Rodrigo Bressan Cristiano Noto Ary Gadelha |
| author_sort | Raffael Massuda |
| collection | DOAJ |
| description | Objective: Clozapine is a second-generation antipsychotic indicated for treatment-resistant schizophrenia. Studies in several countries have shown a low rate of clozapine use despite the fact that approximately 30% of schizophrenia cases are treatment-resistant. In Brazil, few studies have addressed the frequency and variety of antipsychotic use in individuals diagnosed with schizophrenia (ICD F20). The objective of this study was to measure the rates of clozapine use in this population in the last decade using Brazilian Ministry of Health data. Methods: Prescriptions made between 2010 and 2020 in all 26 states and the Federal District registered at the Outpatient Information System Database from the Brazilian Health System (SIASUS) were evaluated. Results: A total of 25,143,524 prescriptions were recorded in this period, with clozapine representing 8.86% of all antipsychotics. The most frequently prescribed antipsychotic for patients with schizophrenia was olanzapine (35.8%), followed by quetiapine (27.5%). From 2010 to 2020, the rate of clozapine prescriptions in Brazil increased from 7.2% to 10.9%. Conclusions: Despite a slight increase in prescriptions in the last decade, clozapine is still underutilized in Brazil. |
| first_indexed | 2024-04-11T19:41:30Z |
| format | Article |
| id | doaj.art-3aa2b604c5754cb6b4a5eaf03a6d74d1 |
| institution | Directory Open Access Journal |
| issn | 1809-452X |
| language | English |
| last_indexed | 2024-04-11T19:41:30Z |
| publishDate | 2022-10-01 |
| publisher | Associação Brasileira de Psiquiatria (ABP) |
| record_format | Article |
| series | Brazilian Journal of Psychiatry |
| spelling | doaj.art-3aa2b604c5754cb6b4a5eaf03a6d74d12022-12-22T04:06:41ZengAssociação Brasileira de Psiquiatria (ABP)Brazilian Journal of Psychiatry1809-452X2022-10-0110.47626/1516-4446-2022-2572Clozapine prescription trends in Brazil in the last decadeRaffael Massudahttps://orcid.org/0000-0002-2627-8022Clarissa S. Gamahttps://orcid.org/0000-0003-2235-9690Paulo Belmonte-de-Abreuhttps://orcid.org/0000-0002-2853-2004Helio Elkishttps://orcid.org/0000-0003-0156-7511David Freitas de Lucenahttps://orcid.org/0000-0002-1547-3711Rodrigo Bressanhttps://orcid.org/0000-0002-0868-4449Cristiano Notohttps://orcid.org/0000-0002-2706-9118Ary Gadelhahttps://orcid.org/0000-0002-0993-8017 Objective: Clozapine is a second-generation antipsychotic indicated for treatment-resistant schizophrenia. Studies in several countries have shown a low rate of clozapine use despite the fact that approximately 30% of schizophrenia cases are treatment-resistant. In Brazil, few studies have addressed the frequency and variety of antipsychotic use in individuals diagnosed with schizophrenia (ICD F20). The objective of this study was to measure the rates of clozapine use in this population in the last decade using Brazilian Ministry of Health data. Methods: Prescriptions made between 2010 and 2020 in all 26 states and the Federal District registered at the Outpatient Information System Database from the Brazilian Health System (SIASUS) were evaluated. Results: A total of 25,143,524 prescriptions were recorded in this period, with clozapine representing 8.86% of all antipsychotics. The most frequently prescribed antipsychotic for patients with schizophrenia was olanzapine (35.8%), followed by quetiapine (27.5%). From 2010 to 2020, the rate of clozapine prescriptions in Brazil increased from 7.2% to 10.9%. Conclusions: Despite a slight increase in prescriptions in the last decade, clozapine is still underutilized in Brazil.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462022005011204&tlng=enClozapineschizophrenia, treatment-resistantantipsychotics |
| spellingShingle | Raffael Massuda Clarissa S. Gama Paulo Belmonte-de-Abreu Helio Elkis David Freitas de Lucena Rodrigo Bressan Cristiano Noto Ary Gadelha Clozapine prescription trends in Brazil in the last decade Brazilian Journal of Psychiatry Clozapine schizophrenia, treatment-resistant antipsychotics |
| title | Clozapine prescription trends in Brazil in the last decade |
| title_full | Clozapine prescription trends in Brazil in the last decade |
| title_fullStr | Clozapine prescription trends in Brazil in the last decade |
| title_full_unstemmed | Clozapine prescription trends in Brazil in the last decade |
| title_short | Clozapine prescription trends in Brazil in the last decade |
| title_sort | clozapine prescription trends in brazil in the last decade |
| topic | Clozapine schizophrenia, treatment-resistant antipsychotics |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462022005011204&tlng=en |
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