Association of Chromosome 17 Aneuploidy, <i>TP53</i> Deletion, Expression and Its rs1042522 Variant with Multiple Myeloma Risk and Response to Thalidomide/Bortezomib Treatment

Association of Chromosome 17 Aneuploidy, <i>TP53</i> Deletion, Expression and Its rs1042522 Variant with Multiple Myeloma Risk and Response to Thalidomide/Bortezomib Treatment

Multiple myeloma (MM) is a multifactorial genetic disorder caused by interactive effects of environmental and genetic factors. The proper <i>locus</i> of the <i>TP53</i> gene (17p13.1) and its protein is essential in genomic stability. The most common variant of the <i>...

Full description

Bibliographic Details
Main Authors: Sylwia Popek-Marciniec, Wojciech Styk, Magdalena Wojcierowska-Litwin, Sylwia Chocholska, Aneta Szudy-Szczyrek, Marzena Samardakiewicz, Grazyna Swiderska-Kolacz, Joanna Czerwik-Marcinkowska, Szymon Zmorzynski
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Cancers
Subjects:
<i>TP53</i> variant
p.P72R polymorphism
<i>TP53</i> expression
17p13 <i>locus</i>
plasma cell myeloma
plasma cells
Online Access:https://www.mdpi.com/2072-6694/15/19/4747

Similar Items

Similar Items