The dynamic monitoring of CEA in response to chemotherapy and prognosis of mCRC patients
Abstract Background The role of carcinoembryonic antigen (CEA) change patterns in tumor response and long-term outcome is unclear. This study aimed to investigate the correlation between changes in CEA levels and tumor response as a potential prognostic model. Methods CEA levels were determined from...
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BMC
2018-11-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-018-4987-0 |
| _version_ | 1818296953063079936 |
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| author | Ping Yu Mingyi Zhou Jinglei Qu Lingyu Fu Xuedan Li Ruimei Cai Bo Jin Yuee Teng Jing Liu Jing Shi Jingdong Zhang |
| author_facet | Ping Yu Mingyi Zhou Jinglei Qu Lingyu Fu Xuedan Li Ruimei Cai Bo Jin Yuee Teng Jing Liu Jing Shi Jingdong Zhang |
| author_sort | Ping Yu |
| collection | DOAJ |
| description | Abstract Background The role of carcinoembryonic antigen (CEA) change patterns in tumor response and long-term outcome is unclear. This study aimed to investigate the correlation between changes in CEA levels and tumor response as a potential prognostic model. Methods CEA levels were determined from baseline to progression. A χ2 test was used to assess the correlation between CEA changes and tumor response. Univariate and multivariate COX models were used to explore the correlation of CEA changes to progression-free survival (PFS) and overall survival (OS). Results All 114 patients were divided into five groups according to CEA change pattern (A: patients had an initial fast CEA decrease that then turned into a slow increase; B: patients had an initial slow CEA decrease that then turned to a slow increase; C: patients had a continually slow CEA increase; D: patients had a continually fast CEA increase; E: patients had an initial fast CEA decrease that then turned into a fast increase). Patients in Group A had the longest OS and PFS while Group E patients had the shortest OS. Baseline to week 12 and week 12 to week 18 change rates were consistent with tumor response and progression, respectively. An increase in CEA level by ≥2.7% from week 12 to 18 was an independent negative prognostic factor of OS. Conclusions CEA changes mirror the tumor response to first-line chemotherapy and are associated with prognosis. CEA monitoring may be a substitute for computed tomography during the CEA stable period of treatment. |
| first_indexed | 2024-12-13T04:11:39Z |
| format | Article |
| id | doaj.art-3aa46e9df47541ba9de0a07cab960e0f |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-13T04:11:39Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-3aa46e9df47541ba9de0a07cab960e0f2022-12-21T23:59:59ZengBMCBMC Cancer1471-24072018-11-011811910.1186/s12885-018-4987-0The dynamic monitoring of CEA in response to chemotherapy and prognosis of mCRC patientsPing Yu0Mingyi Zhou1Jinglei Qu2Lingyu Fu3Xuedan Li4Ruimei Cai5Bo Jin6Yuee Teng7Jing Liu8Jing Shi9Jingdong Zhang10Department of Medical Oncology, The First Hospital of China Medical UniversityDepartment of Gynecology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & InstituteDepartment of Medical Oncology, The First Hospital of China Medical UniversityDepartment of Clinical Epidemiology and Evidence Based Medicine, The First Hospital of China Medical UniversityDepartment of Radiology, The First Hospital of China Medical UniversityDepartment of Radiology, The First Hospital of China Medical UniversityDepartment of Medical Oncology, The First Hospital of China Medical UniversityDepartment of Medical Oncology, The First Hospital of China Medical UniversityDepartment of Medical Oncology, The First Hospital of China Medical UniversityDepartment of Medical Oncology, The First Hospital of China Medical UniversityDepartment of Medical Oncology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & InstituteAbstract Background The role of carcinoembryonic antigen (CEA) change patterns in tumor response and long-term outcome is unclear. This study aimed to investigate the correlation between changes in CEA levels and tumor response as a potential prognostic model. Methods CEA levels were determined from baseline to progression. A χ2 test was used to assess the correlation between CEA changes and tumor response. Univariate and multivariate COX models were used to explore the correlation of CEA changes to progression-free survival (PFS) and overall survival (OS). Results All 114 patients were divided into five groups according to CEA change pattern (A: patients had an initial fast CEA decrease that then turned into a slow increase; B: patients had an initial slow CEA decrease that then turned to a slow increase; C: patients had a continually slow CEA increase; D: patients had a continually fast CEA increase; E: patients had an initial fast CEA decrease that then turned into a fast increase). Patients in Group A had the longest OS and PFS while Group E patients had the shortest OS. Baseline to week 12 and week 12 to week 18 change rates were consistent with tumor response and progression, respectively. An increase in CEA level by ≥2.7% from week 12 to 18 was an independent negative prognostic factor of OS. Conclusions CEA changes mirror the tumor response to first-line chemotherapy and are associated with prognosis. CEA monitoring may be a substitute for computed tomography during the CEA stable period of treatment.http://link.springer.com/article/10.1186/s12885-018-4987-0CEA changeTumor responseProgressionMetastatic colorectal cancer |
| spellingShingle | Ping Yu Mingyi Zhou Jinglei Qu Lingyu Fu Xuedan Li Ruimei Cai Bo Jin Yuee Teng Jing Liu Jing Shi Jingdong Zhang The dynamic monitoring of CEA in response to chemotherapy and prognosis of mCRC patients BMC Cancer CEA change Tumor response Progression Metastatic colorectal cancer |
| title | The dynamic monitoring of CEA in response to chemotherapy and prognosis of mCRC patients |
| title_full | The dynamic monitoring of CEA in response to chemotherapy and prognosis of mCRC patients |
| title_fullStr | The dynamic monitoring of CEA in response to chemotherapy and prognosis of mCRC patients |
| title_full_unstemmed | The dynamic monitoring of CEA in response to chemotherapy and prognosis of mCRC patients |
| title_short | The dynamic monitoring of CEA in response to chemotherapy and prognosis of mCRC patients |
| title_sort | dynamic monitoring of cea in response to chemotherapy and prognosis of mcrc patients |
| topic | CEA change Tumor response Progression Metastatic colorectal cancer |
| url | http://link.springer.com/article/10.1186/s12885-018-4987-0 |
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