Serum thrombopoietin and cMpl expression in thrombocytopenia of different etiologies
The relationship between thrombopoietin (TPO) and its receptor cMpl in thrombocytopenic conditions has not been entirely clarified. To elucidate this interplay may expand the spectrum of indications of TPO mimetics. In this study we have explored the relationship between TPO and cMpl in platelets an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-03-01
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| Series: | Hematology Reports |
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| Online Access: | http://www.pagepress.org/journals/index.php/hr/article/view/4996 |
| _version_ | 1811173790874337280 |
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| author | Fabrizio Vianello Silvia Vettore Fabiana Tezza Luca De Toni Raffaella Scandellari Luisa Sambado Martina Treleani Fabrizio Fabris |
| author_facet | Fabrizio Vianello Silvia Vettore Fabiana Tezza Luca De Toni Raffaella Scandellari Luisa Sambado Martina Treleani Fabrizio Fabris |
| author_sort | Fabrizio Vianello |
| collection | DOAJ |
| description | The relationship between thrombopoietin (TPO) and its receptor cMpl in thrombocytopenic conditions has not been entirely clarified. To elucidate this interplay may expand the spectrum of indications of TPO mimetics. In this study we have explored the relationship between TPO and cMpl in platelets and megakaryocytes of 43 patients with thrombocytopenia due to idiopathic thrombocytopenic purpura (ITP), bone marrow hypoplasia, myelodysplastic syndromes (MDS), and familial thrombocytopenia. Data were compared to cMpl and TPO in patients with a normal platelet count and in patients with thrombocytosis due to essential thrombocythemia (ET). All but familial patients showed higher TPO compared to controls. All thrombocytopenic states were invariably associated with increased expression of platelet cMPL compared to healthy controls. ET patients showed normal TPO and a trend toward a reduced cMpl expression. Immunofluorescence of bone marrow sections from patients with ITP and MDS failed to show a peculiar pattern compared to controls. Multiple mechanisms regulate TPO and cMpl in thrombocytopenic conditions. |
| first_indexed | 2024-04-10T17:52:44Z |
| format | Article |
| id | doaj.art-3aa48602215a47a4b754fd9dfb74d09d |
| institution | Directory Open Access Journal |
| issn | 2038-8322 2038-8330 |
| language | English |
| last_indexed | 2024-04-10T17:52:44Z |
| publishDate | 2014-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hematology Reports |
| spelling | doaj.art-3aa48602215a47a4b754fd9dfb74d09d2023-02-02T19:58:32ZengMDPI AGHematology Reports2038-83222038-83302014-03-016110.4081/hr.2014.49962765Serum thrombopoietin and cMpl expression in thrombocytopenia of different etiologiesFabrizio Vianello0Silvia Vettore1Fabiana Tezza2Luca De Toni3Raffaella Scandellari4Luisa Sambado5Martina Treleani6Fabrizio Fabris7Internal Medicine Unit, Department of Medicine DIMED, University of Padova Medical School, PadovaInternal Medicine Unit, Department of Medicine DIMED, University of Padova Medical School, PadovaInternal Medicine Unit, Department of Medicine DIMED, University of Padova Medical School, PadovaCentre for Human Reproduction Pathology, Department of Medicine DIMED, University of Padova Medical School, PadovaInternal Medicine Unit, Department of Medicine DIMED, University of Padova Medical School, PadovaInternal Medicine Unit, Department of Medicine DIMED, University of Padova Medical School, PadovaInternal Medicine Unit, Department of Medicine DIMED, University of Padova Medical School, PadovaInternal Medicine Unit, Department of Medicine DIMED, University of Padova Medical School, PadovaThe relationship between thrombopoietin (TPO) and its receptor cMpl in thrombocytopenic conditions has not been entirely clarified. To elucidate this interplay may expand the spectrum of indications of TPO mimetics. In this study we have explored the relationship between TPO and cMpl in platelets and megakaryocytes of 43 patients with thrombocytopenia due to idiopathic thrombocytopenic purpura (ITP), bone marrow hypoplasia, myelodysplastic syndromes (MDS), and familial thrombocytopenia. Data were compared to cMpl and TPO in patients with a normal platelet count and in patients with thrombocytosis due to essential thrombocythemia (ET). All but familial patients showed higher TPO compared to controls. All thrombocytopenic states were invariably associated with increased expression of platelet cMPL compared to healthy controls. ET patients showed normal TPO and a trend toward a reduced cMpl expression. Immunofluorescence of bone marrow sections from patients with ITP and MDS failed to show a peculiar pattern compared to controls. Multiple mechanisms regulate TPO and cMpl in thrombocytopenic conditions.http://www.pagepress.org/journals/index.php/hr/article/view/4996thrombocytopenia, thrombopoietin, thrombopoietin receptor, thrombopoiesis |
| spellingShingle | Fabrizio Vianello Silvia Vettore Fabiana Tezza Luca De Toni Raffaella Scandellari Luisa Sambado Martina Treleani Fabrizio Fabris Serum thrombopoietin and cMpl expression in thrombocytopenia of different etiologies Hematology Reports thrombocytopenia, thrombopoietin, thrombopoietin receptor, thrombopoiesis |
| title | Serum thrombopoietin and cMpl expression in thrombocytopenia of different etiologies |
| title_full | Serum thrombopoietin and cMpl expression in thrombocytopenia of different etiologies |
| title_fullStr | Serum thrombopoietin and cMpl expression in thrombocytopenia of different etiologies |
| title_full_unstemmed | Serum thrombopoietin and cMpl expression in thrombocytopenia of different etiologies |
| title_short | Serum thrombopoietin and cMpl expression in thrombocytopenia of different etiologies |
| title_sort | serum thrombopoietin and cmpl expression in thrombocytopenia of different etiologies |
| topic | thrombocytopenia, thrombopoietin, thrombopoietin receptor, thrombopoiesis |
| url | http://www.pagepress.org/journals/index.php/hr/article/view/4996 |
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