A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report
A 48-year-old man was admitted for evaluation of abnormal shadows on chest radiograph. Chest computed tomography (CT) showed cysts, nodules, and cervical and axillary lymphadenopathies. Elevated serum levels of IgG4 and interleukin (IL)-6 suggested IgG4-related disease (IgG4-RD) or multicentric Cast...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-01-01
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| Series: | Respiratory Medicine Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007117300953 |
| _version_ | 1818854695859388416 |
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| author | Hironori Mikumo Naoki Hamada Eiji Harada Toyoshi Yanagihara Saiko Ogata Hidetake Yabuuchi Kayo Ijichi Koichi Takayama Yoichi Nakanishi |
| author_facet | Hironori Mikumo Naoki Hamada Eiji Harada Toyoshi Yanagihara Saiko Ogata Hidetake Yabuuchi Kayo Ijichi Koichi Takayama Yoichi Nakanishi |
| author_sort | Hironori Mikumo |
| collection | DOAJ |
| description | A 48-year-old man was admitted for evaluation of abnormal shadows on chest radiograph. Chest computed tomography (CT) showed cysts, nodules, and cervical and axillary lymphadenopathies. Elevated serum levels of IgG4 and interleukin (IL)-6 suggested IgG4-related disease (IgG4-RD) or multicentric Castleman's disease (MCD). Histologic findings of the cervical lymph node and right lung S6 biopsies revealed numerous IgG4-positive plasma cells. Although CT findings of the lungs were atypical for IgG4-RD, consistent histologic findings, clinical symptoms, and laboratory data made us conclude IgG4-RD. Because histologic findings of IgG4-RD and MCD have similarities, differentiating between the two diseases should consider the clinical presentation. |
| first_indexed | 2024-12-19T07:56:48Z |
| format | Article |
| id | doaj.art-3aa5041d58414a9f8caca18635c75a9d |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-12-19T07:56:48Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-3aa5041d58414a9f8caca18635c75a9d2022-12-21T20:29:59ZengElsevierRespiratory Medicine Case Reports2213-00712017-01-0121C899210.1016/j.rmcr.2017.03.023A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case reportHironori Mikumo0Naoki Hamada1Eiji Harada2Toyoshi Yanagihara3Saiko Ogata4Hidetake Yabuuchi5Kayo Ijichi6Koichi Takayama7Yoichi Nakanishi8Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, JapanResearch Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, JapanResearch Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, JapanResearch Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, JapanResearch Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, JapanDepartment of Health Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, JapanResearch Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, JapanResearch Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, JapanResearch Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, JapanA 48-year-old man was admitted for evaluation of abnormal shadows on chest radiograph. Chest computed tomography (CT) showed cysts, nodules, and cervical and axillary lymphadenopathies. Elevated serum levels of IgG4 and interleukin (IL)-6 suggested IgG4-related disease (IgG4-RD) or multicentric Castleman's disease (MCD). Histologic findings of the cervical lymph node and right lung S6 biopsies revealed numerous IgG4-positive plasma cells. Although CT findings of the lungs were atypical for IgG4-RD, consistent histologic findings, clinical symptoms, and laboratory data made us conclude IgG4-RD. Because histologic findings of IgG4-RD and MCD have similarities, differentiating between the two diseases should consider the clinical presentation.http://www.sciencedirect.com/science/article/pii/S2213007117300953IgG4-related diseaseIgG4-related respiratory diseaseMulticentric Castleman's diseasePulmonary cystMultiple lymphadenopathy |
| spellingShingle | Hironori Mikumo Naoki Hamada Eiji Harada Toyoshi Yanagihara Saiko Ogata Hidetake Yabuuchi Kayo Ijichi Koichi Takayama Yoichi Nakanishi A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report Respiratory Medicine Case Reports IgG4-related disease IgG4-related respiratory disease Multicentric Castleman's disease Pulmonary cyst Multiple lymphadenopathy |
| title | A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report |
| title_full | A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report |
| title_fullStr | A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report |
| title_full_unstemmed | A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report |
| title_short | A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report |
| title_sort | case of immunoglobulin g4 related respiratory disease with multiple lung cysts a case report |
| topic | IgG4-related disease IgG4-related respiratory disease Multicentric Castleman's disease Pulmonary cyst Multiple lymphadenopathy |
| url | http://www.sciencedirect.com/science/article/pii/S2213007117300953 |
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