A single full-length VAR2CSA ectodomain variant purifies broadly neutralizing antibodies against placental malaria isolates

A single full-length VAR2CSA ectodomain variant purifies broadly neutralizing antibodies against placental malaria isolates

Placental malaria (PM) is a deadly syndrome most frequent and severe in first pregnancies. PM results from accumulation of Plasmodium falciparum-infected erythrocytes (IE) that express the surface antigen VAR2CSA and bind to chondroitin sulfate A (CSA) in the placenta. Women become PM-resistant over...

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Bibliographic Details
Main Authors: Justin YA Doritchamou, Jonathan P Renn, Bethany Jenkins, Almahamoudou Mahamar, Alassane Dicko, Michal Fried, Patrick E Duffy
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-02-01
Series:eLife
Subjects:
pregnancy
malaria
vaccine
VAR2CSA
variant
blocking antibody
Online Access:https://elifesciences.org/articles/76264

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