Multi drug resistance in Colorectal Cancer- approaches to overcome, advancements and future success
A significant obstacle to treating cancer is multidrug resistance (MDR), which is the capacity of cancerous cells to develop resistance to both traditional and cutting-edge chemotherapeutic treatments. Following the initial discovery that cellular pumps reliant on ATP were the root of chemotherapy r...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-07-01
|
| Series: | Advances in Cancer Biology - Metastasis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667394024000017 |
| _version_ | 1797352617410560000 |
|---|---|
| author | Sumel Ashique Mithun Bhowmick Radheshyam Pal Heya Khatoon Prashant Kumar Himanshu Sharma Ashish Garg Shubneesh Kumar Ushasi Das |
| author_facet | Sumel Ashique Mithun Bhowmick Radheshyam Pal Heya Khatoon Prashant Kumar Himanshu Sharma Ashish Garg Shubneesh Kumar Ushasi Das |
| author_sort | Sumel Ashique |
| collection | DOAJ |
| description | A significant obstacle to treating cancer is multidrug resistance (MDR), which is the capacity of cancerous cells to develop resistance to both traditional and cutting-edge chemotherapeutic treatments. Following the initial discovery that cellular pumps reliant on ATP were the root of chemotherapy resistance, more research has revealed the involvement of additional mechanisms, including increased drug metabolism, reduced drug entry, and compromised apoptotic pathways. Numerous projects have focused on MDR, and innumerable research has been conducted to better understand MDR and develop methods to mitigate its consequences. Multidrug resistance (MDR) is a key challenge in treating cancer. 90% of cancer-related fatalities are brought on by tumor metastasis and recurrence, which is possible with MDR. Drug resistance in cancerous cells is influenced by diverse internal and extrinsic variables, including genetic and epigenetic changes, drug efflux systems, DNA repair mechanisms, apoptosis, and autophagy. In this review paper, we list the potential hazards associated with cancer therapy in general, primarily multidrug resistance developing a theory for colorectal cancer in particular. We discussed the unique instance of multidrug resistance in colorectal cancer in malignancies generally and 5-fluorouracil, curcumin, and lipids as viable therapy options for the condition. The use of nanotechnology (mainly nanoparticles) has facilitated better in vitro as well as in vivo efficacy during preclinical phases, summarized below, allowing for a more thorough investigation of colorectal cancers and pancreatic carcinomas with their translation to following clinical trials. |
| first_indexed | 2024-03-08T13:18:20Z |
| format | Article |
| id | doaj.art-3aa6bb7e7b754c34837a5215ec3d5556 |
| institution | Directory Open Access Journal |
| issn | 2667-3940 |
| language | English |
| last_indexed | 2024-03-08T13:18:20Z |
| publishDate | 2024-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Cancer Biology - Metastasis |
| spelling | doaj.art-3aa6bb7e7b754c34837a5215ec3d55562024-01-18T04:18:44ZengElsevierAdvances in Cancer Biology - Metastasis2667-39402024-07-0110100114Multi drug resistance in Colorectal Cancer- approaches to overcome, advancements and future successSumel Ashique0Mithun Bhowmick1Radheshyam Pal2Heya Khatoon3Prashant Kumar4Himanshu Sharma5Ashish Garg6Shubneesh Kumar7Ushasi Das8Department of Pharmaceutical Sciences, Bengal College of Pharmaceutical Sciences & Research, Durgapur, 713212, West Bengal, India; Corresponding author.Department of Pharmaceutical Sciences, Bengal College of Pharmaceutical Sciences & Research, Durgapur, 713212, West Bengal, IndiaDepartment of Pharmacy, Pandaveswar School of Pharmacy, Pandaveswar, West Bengal, 713378, IndiaDepartment of Pharmacy, Pandaveswar School of Pharmacy, Pandaveswar, West Bengal, 713378, IndiaTeerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad (UP)-244001, IndiaTeerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad (UP)-244001, IndiaDepartment of Pharmaceutics, Guru Ramdas Khalsa Institute of Science and Technology (Pharmacy), Jabalpur, Madhya Pradesh, IndiaDepartment of Pharmaceutics, Bharat Institute of Technology, School of Pharmacy, Meerut, IndiaJadavpur University, Department of Pharmaceutical Technology, 188, Raja S.C. Mallick Road, Kolkata, West Bengal, 700032, IndiaA significant obstacle to treating cancer is multidrug resistance (MDR), which is the capacity of cancerous cells to develop resistance to both traditional and cutting-edge chemotherapeutic treatments. Following the initial discovery that cellular pumps reliant on ATP were the root of chemotherapy resistance, more research has revealed the involvement of additional mechanisms, including increased drug metabolism, reduced drug entry, and compromised apoptotic pathways. Numerous projects have focused on MDR, and innumerable research has been conducted to better understand MDR and develop methods to mitigate its consequences. Multidrug resistance (MDR) is a key challenge in treating cancer. 90% of cancer-related fatalities are brought on by tumor metastasis and recurrence, which is possible with MDR. Drug resistance in cancerous cells is influenced by diverse internal and extrinsic variables, including genetic and epigenetic changes, drug efflux systems, DNA repair mechanisms, apoptosis, and autophagy. In this review paper, we list the potential hazards associated with cancer therapy in general, primarily multidrug resistance developing a theory for colorectal cancer in particular. We discussed the unique instance of multidrug resistance in colorectal cancer in malignancies generally and 5-fluorouracil, curcumin, and lipids as viable therapy options for the condition. The use of nanotechnology (mainly nanoparticles) has facilitated better in vitro as well as in vivo efficacy during preclinical phases, summarized below, allowing for a more thorough investigation of colorectal cancers and pancreatic carcinomas with their translation to following clinical trials.http://www.sciencedirect.com/science/article/pii/S2667394024000017Colorectal cancer (CRC)Multidrug resistance (MDR)P-gp5-FUCurcuminNanomedicines |
| spellingShingle | Sumel Ashique Mithun Bhowmick Radheshyam Pal Heya Khatoon Prashant Kumar Himanshu Sharma Ashish Garg Shubneesh Kumar Ushasi Das Multi drug resistance in Colorectal Cancer- approaches to overcome, advancements and future success Advances in Cancer Biology - Metastasis Colorectal cancer (CRC) Multidrug resistance (MDR) P-gp 5-FU Curcumin Nanomedicines |
| title | Multi drug resistance in Colorectal Cancer- approaches to overcome, advancements and future success |
| title_full | Multi drug resistance in Colorectal Cancer- approaches to overcome, advancements and future success |
| title_fullStr | Multi drug resistance in Colorectal Cancer- approaches to overcome, advancements and future success |
| title_full_unstemmed | Multi drug resistance in Colorectal Cancer- approaches to overcome, advancements and future success |
| title_short | Multi drug resistance in Colorectal Cancer- approaches to overcome, advancements and future success |
| title_sort | multi drug resistance in colorectal cancer approaches to overcome advancements and future success |
| topic | Colorectal cancer (CRC) Multidrug resistance (MDR) P-gp 5-FU Curcumin Nanomedicines |
| url | http://www.sciencedirect.com/science/article/pii/S2667394024000017 |
| work_keys_str_mv | AT sumelashique multidrugresistanceincolorectalcancerapproachestoovercomeadvancementsandfuturesuccess AT mithunbhowmick multidrugresistanceincolorectalcancerapproachestoovercomeadvancementsandfuturesuccess AT radheshyampal multidrugresistanceincolorectalcancerapproachestoovercomeadvancementsandfuturesuccess AT heyakhatoon multidrugresistanceincolorectalcancerapproachestoovercomeadvancementsandfuturesuccess AT prashantkumar multidrugresistanceincolorectalcancerapproachestoovercomeadvancementsandfuturesuccess AT himanshusharma multidrugresistanceincolorectalcancerapproachestoovercomeadvancementsandfuturesuccess AT ashishgarg multidrugresistanceincolorectalcancerapproachestoovercomeadvancementsandfuturesuccess AT shubneeshkumar multidrugresistanceincolorectalcancerapproachestoovercomeadvancementsandfuturesuccess AT ushasidas multidrugresistanceincolorectalcancerapproachestoovercomeadvancementsandfuturesuccess |