Activation of PXR, CAR and PPARα by pyrethroid pesticides and the effect of metabolism by rat liver microsomes

Activation of PXR, CAR and PPARα by pyrethroid pesticides and the effect of metabolism by rat liver microsomes

In this study, we used reporter gene assays in COS-1 cells to examine the activation of rat pregnane X receptor (PXR), rat constitutive androstane receptor (CAR) and rat peroxisome-proliferator activated receptor (PPAR)α by pyrethroid pesticides, and to understand the effects of metabolic modificati...

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Bibliographic Details
Main Authors: Chieri Fujino, Yoko Watanabe, Seigo Sanoh, Hiroyuki Nakajima, Naoto Uramaru, Hiroyuki Kojima, Kouichi Yoshinari, Shigeru Ohta, Shigeyuki Kitamura
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Heliyon
Subjects:
Environmental health
Environmental science
Pesticide
Toxicology
CAR
Liver microsomes
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844019361262

Internet

http://www.sciencedirect.com/science/article/pii/S2405844019361262

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