Pharmaceutical significance of Schiff bases: an overview
Abstract Schiff bases are a diverse group of organic compounds with great pharmaceutical importance due to the presence of carbon–nitrogen double bonds (–C=N–). These compounds are synthesized by the condensation reaction between a primary amine and an aldehyde or ketone in a suitable solvent such a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2024-02-01
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| Series: | Future Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43094-024-00594-5 |
| _version_ | 1797275539129499648 |
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| author | Irfan Mushtaq Maqbool Ahmad Muhammad Saleem Adnan Ahmed |
| author_facet | Irfan Mushtaq Maqbool Ahmad Muhammad Saleem Adnan Ahmed |
| author_sort | Irfan Mushtaq |
| collection | DOAJ |
| description | Abstract Schiff bases are a diverse group of organic compounds with great pharmaceutical importance due to the presence of carbon–nitrogen double bonds (–C=N–). These compounds are synthesized by the condensation reaction between a primary amine and an aldehyde or ketone in a suitable solvent such as methanol. These compounds have shown antibacterial, antifungal, antiviral, anti-inflammatory, and antioxidant activities, which have garnered the attention of organic chemists in synthesizing these compounds. Recent advances have been summarized in this review paper mainly including compounds with potential antibacterial, antifungal, and antiviral activities. Synthetic schemes are included to provide a better understanding of the Schiff base synthesis mechanism. This review paper will provide a way forward for the pharmaceutical chemist to synthesize new compounds with potential biological activities. Graphical abstract |
| first_indexed | 2024-03-07T15:15:56Z |
| format | Article |
| id | doaj.art-3aae6eb3182646d99e88cc88a8346223 |
| institution | Directory Open Access Journal |
| issn | 2314-7253 |
| language | English |
| last_indexed | 2024-03-07T15:15:56Z |
| publishDate | 2024-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Future Journal of Pharmaceutical Sciences |
| spelling | doaj.art-3aae6eb3182646d99e88cc88a83462232024-03-05T17:55:13ZengSpringerOpenFuture Journal of Pharmaceutical Sciences2314-72532024-02-0110111210.1186/s43094-024-00594-5Pharmaceutical significance of Schiff bases: an overviewIrfan Mushtaq0Maqbool Ahmad1Muhammad Saleem2Adnan Ahmed3Department of Chemistry, Ghazi UniversityDepartment of Chemistry, Ghazi UniversityDepartment of Chemistry, Ghazi UniversityInstitute of Chemical Sciences, Gomal UniversityAbstract Schiff bases are a diverse group of organic compounds with great pharmaceutical importance due to the presence of carbon–nitrogen double bonds (–C=N–). These compounds are synthesized by the condensation reaction between a primary amine and an aldehyde or ketone in a suitable solvent such as methanol. These compounds have shown antibacterial, antifungal, antiviral, anti-inflammatory, and antioxidant activities, which have garnered the attention of organic chemists in synthesizing these compounds. Recent advances have been summarized in this review paper mainly including compounds with potential antibacterial, antifungal, and antiviral activities. Synthetic schemes are included to provide a better understanding of the Schiff base synthesis mechanism. This review paper will provide a way forward for the pharmaceutical chemist to synthesize new compounds with potential biological activities. Graphical abstracthttps://doi.org/10.1186/s43094-024-00594-5Schiff basesIminesBiological activitiesCondensation reactionSynthesisReview |
| spellingShingle | Irfan Mushtaq Maqbool Ahmad Muhammad Saleem Adnan Ahmed Pharmaceutical significance of Schiff bases: an overview Future Journal of Pharmaceutical Sciences Schiff bases Imines Biological activities Condensation reaction Synthesis Review |
| title | Pharmaceutical significance of Schiff bases: an overview |
| title_full | Pharmaceutical significance of Schiff bases: an overview |
| title_fullStr | Pharmaceutical significance of Schiff bases: an overview |
| title_full_unstemmed | Pharmaceutical significance of Schiff bases: an overview |
| title_short | Pharmaceutical significance of Schiff bases: an overview |
| title_sort | pharmaceutical significance of schiff bases an overview |
| topic | Schiff bases Imines Biological activities Condensation reaction Synthesis Review |
| url | https://doi.org/10.1186/s43094-024-00594-5 |
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