Changes in Hepcidin Serum Levels Correlate with Clinical Improvement in Idiopathic Restless Legs Syndrome Patients
Background: Restless legs syndrome (RLS) is a common sensory motor neurological disorder that is related to iron–dopamine dysregulation and immune system alteration. We aimed to assess the effects of serum hepcidin, an iron-regulating hormone, in drug-naive RLS patients compared to healthy controls...
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| Format: | Article |
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MDPI AG
2020-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/12/4115 |
| _version_ | 1797544053492940800 |
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| author | Hee-Jin Im Jee Hyun Kim Chang-Ho Yun Dong Wook Kim Jeeyoung Oh |
| author_facet | Hee-Jin Im Jee Hyun Kim Chang-Ho Yun Dong Wook Kim Jeeyoung Oh |
| author_sort | Hee-Jin Im |
| collection | DOAJ |
| description | Background: Restless legs syndrome (RLS) is a common sensory motor neurological disorder that is related to iron–dopamine dysregulation and immune system alteration. We aimed to assess the effects of serum hepcidin, an iron-regulating hormone, in drug-naive RLS patients compared to healthy controls and to evaluate its role in helping to predict clinical improvement after treatment with dopamine agonist. Methods: Nonanemic and drug-naive RLS patients (<i>n</i> = 18) and healthy controls (<i>n</i> = 15) were enrolled. The serum hepcidin and iron-related values in the serum were measured upon the first visit in both groups and 12 weeks later after dopaminergic treatment in 12 patients. Information about sociodemographic characteristics, sleep-related profiles, mood and anxiety was obtained upon the first visit in all participants as well as after treatment in RLS patients. Results: Serum hepcidin levels exhibited no significant differences between patients with drug-naïve RLS and healthy controls at diagnosis (7.1 ± 2.4 vs. 7.0 ± 3.2 ng/mL, <i>p</i> = 0.357). Decreased hepcidin levels were significantly associated with decreased RLS severity (β = 0.002, 95% CI = 0.00−0.00, <i>p</i> = 0.005) and improved quality of life (β = 0.002, 95% CI = 0.00−7.01, <i>p</i> = 0.044) in a dose-dependent manner after 12 weeks of treatment with a dopamine agonist. This association was independent of age, sex, inflammatory markers, sleep quality, insomnia, daytime sleepiness, depression and anxiety. Conclusions: This study demonstrates the role of hepcidin in evaluating the positive therapeutic response in RLS. |
| first_indexed | 2024-03-10T13:54:04Z |
| format | Article |
| id | doaj.art-3ab0e4401b684137bd487de79f96c6a3 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T13:54:04Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-3ab0e4401b684137bd487de79f96c6a32023-11-21T01:44:34ZengMDPI AGJournal of Clinical Medicine2077-03832020-12-01912411510.3390/jcm9124115Changes in Hepcidin Serum Levels Correlate with Clinical Improvement in Idiopathic Restless Legs Syndrome PatientsHee-Jin Im0Jee Hyun Kim1Chang-Ho Yun2Dong Wook Kim3Jeeyoung Oh4Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong 18450, KoreaDepartment of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University School of Medicine, Seoul 07804, KoreaDepartment of Neurology, Seoul National University Bundang Hospital, Seongnam 13620, KoreaDepartment of Neurology, School of Medicine, Konkuk University Hospital, Konkuk University, Seoul 05030, KoreaDepartment of Neurology, School of Medicine, Konkuk University Hospital, Konkuk University, Seoul 05030, KoreaBackground: Restless legs syndrome (RLS) is a common sensory motor neurological disorder that is related to iron–dopamine dysregulation and immune system alteration. We aimed to assess the effects of serum hepcidin, an iron-regulating hormone, in drug-naive RLS patients compared to healthy controls and to evaluate its role in helping to predict clinical improvement after treatment with dopamine agonist. Methods: Nonanemic and drug-naive RLS patients (<i>n</i> = 18) and healthy controls (<i>n</i> = 15) were enrolled. The serum hepcidin and iron-related values in the serum were measured upon the first visit in both groups and 12 weeks later after dopaminergic treatment in 12 patients. Information about sociodemographic characteristics, sleep-related profiles, mood and anxiety was obtained upon the first visit in all participants as well as after treatment in RLS patients. Results: Serum hepcidin levels exhibited no significant differences between patients with drug-naïve RLS and healthy controls at diagnosis (7.1 ± 2.4 vs. 7.0 ± 3.2 ng/mL, <i>p</i> = 0.357). Decreased hepcidin levels were significantly associated with decreased RLS severity (β = 0.002, 95% CI = 0.00−0.00, <i>p</i> = 0.005) and improved quality of life (β = 0.002, 95% CI = 0.00−7.01, <i>p</i> = 0.044) in a dose-dependent manner after 12 weeks of treatment with a dopamine agonist. This association was independent of age, sex, inflammatory markers, sleep quality, insomnia, daytime sleepiness, depression and anxiety. Conclusions: This study demonstrates the role of hepcidin in evaluating the positive therapeutic response in RLS.https://www.mdpi.com/2077-0383/9/12/4115hepcidintreatment responserestless legs syndromeIRLSquality of life |
| spellingShingle | Hee-Jin Im Jee Hyun Kim Chang-Ho Yun Dong Wook Kim Jeeyoung Oh Changes in Hepcidin Serum Levels Correlate with Clinical Improvement in Idiopathic Restless Legs Syndrome Patients Journal of Clinical Medicine hepcidin treatment response restless legs syndrome IRLS quality of life |
| title | Changes in Hepcidin Serum Levels Correlate with Clinical Improvement in Idiopathic Restless Legs Syndrome Patients |
| title_full | Changes in Hepcidin Serum Levels Correlate with Clinical Improvement in Idiopathic Restless Legs Syndrome Patients |
| title_fullStr | Changes in Hepcidin Serum Levels Correlate with Clinical Improvement in Idiopathic Restless Legs Syndrome Patients |
| title_full_unstemmed | Changes in Hepcidin Serum Levels Correlate with Clinical Improvement in Idiopathic Restless Legs Syndrome Patients |
| title_short | Changes in Hepcidin Serum Levels Correlate with Clinical Improvement in Idiopathic Restless Legs Syndrome Patients |
| title_sort | changes in hepcidin serum levels correlate with clinical improvement in idiopathic restless legs syndrome patients |
| topic | hepcidin treatment response restless legs syndrome IRLS quality of life |
| url | https://www.mdpi.com/2077-0383/9/12/4115 |
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