Mutations in the Interleukin-15 Gene as a Molecular Biomarker in the Atherosclerosis Disease.
The present study investigated the association between mutations in the gene of interleukin (IL)-15 located on exon 8 and the risk of atherosclerosis in Iraqi patients. A total of 87 patients (71 males and 16 females) with atherosclerosis prior to [Coronary Artery Bypass Graft (CABG) surgery]...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Salahaddin University-Erbil
2023-10-01
|
| Series: | Zanco Journal of Pure and Applied Sciences |
| Subjects: | |
| Online Access: | https://zancojournal.su.edu.krd/index.php/JPAS/article/view/734 |
| _version_ | 1827129088717881344 |
|---|---|
| author | Sarbaz I. Mohammed |
| author_facet | Sarbaz I. Mohammed |
| author_sort | Sarbaz I. Mohammed |
| collection | DOAJ |
| description |
The present study investigated the association between mutations in the gene of interleukin (IL)-15 located on exon 8 and the risk of atherosclerosis in Iraqi patients. A total of 87 patients (71 males and 16 females) with atherosclerosis prior to [Coronary Artery Bypass Graft (CABG) surgery] median age, 57 years and 30 subjects with no CVD (median age, 58.5 years) were enrolled at the Surgical Specialty Hospital of Cardiac Center-Erbil-Iraq between April 2021 and February 2022. Genotype analysis was achieved using a polymerase chain reaction (PCR) and Sanger DNA sequencing and clinical biochemistry were achieved by Cobas 311and e411 analyzers. The IL-15 homozygous rs2291596 (53.3%) and rs10833 (100%) genotypes appeared in peak frequencies and were related to a risk of the progress of atherosclerosis. In comparison, the remaining two novel mutations exhibited a low frequency for the 97264 G>GC genotype (13.3%) and the 97270 G>GT genotype (26.7%). Significant changes were observed in serum C-reactive protein (CRP) levels, the erythrocyte sedimentation rate (ESR), and high-density lipoprotein (HDL), alkaline phosphatase (ALP), blood fasting glucose, hemoglobin A1c (HbA1c) and troponin T-hs levels in the patients with atherosclerosis compared with those of the non-CVD subjects. Finally, it was concluded that the IL-15 mutations may play an essential role in the development and prognostic prediction of blood vessel atherosclerosis.
|
| first_indexed | 2024-03-08T11:51:11Z |
| format | Article |
| id | doaj.art-3ab256848999428b8b2c928edbaf5947 |
| institution | Directory Open Access Journal |
| issn | 2218-0230 2412-3986 |
| language | English |
| last_indexed | 2025-03-20T15:54:44Z |
| publishDate | 2023-10-01 |
| publisher | Salahaddin University-Erbil |
| record_format | Article |
| series | Zanco Journal of Pure and Applied Sciences |
| spelling | doaj.art-3ab256848999428b8b2c928edbaf59472024-09-02T08:56:58ZengSalahaddin University-ErbilZanco Journal of Pure and Applied Sciences2218-02302412-39862023-10-0135510.21271/ZJPAS.35.5.8Mutations in the Interleukin-15 Gene as a Molecular Biomarker in the Atherosclerosis Disease.Sarbaz I. Mohammed0Department of Biology, College of Science, Salahaddin University-Erbil, Kurdistan Region, Iraq The present study investigated the association between mutations in the gene of interleukin (IL)-15 located on exon 8 and the risk of atherosclerosis in Iraqi patients. A total of 87 patients (71 males and 16 females) with atherosclerosis prior to [Coronary Artery Bypass Graft (CABG) surgery] median age, 57 years and 30 subjects with no CVD (median age, 58.5 years) were enrolled at the Surgical Specialty Hospital of Cardiac Center-Erbil-Iraq between April 2021 and February 2022. Genotype analysis was achieved using a polymerase chain reaction (PCR) and Sanger DNA sequencing and clinical biochemistry were achieved by Cobas 311and e411 analyzers. The IL-15 homozygous rs2291596 (53.3%) and rs10833 (100%) genotypes appeared in peak frequencies and were related to a risk of the progress of atherosclerosis. In comparison, the remaining two novel mutations exhibited a low frequency for the 97264 G>GC genotype (13.3%) and the 97270 G>GT genotype (26.7%). Significant changes were observed in serum C-reactive protein (CRP) levels, the erythrocyte sedimentation rate (ESR), and high-density lipoprotein (HDL), alkaline phosphatase (ALP), blood fasting glucose, hemoglobin A1c (HbA1c) and troponin T-hs levels in the patients with atherosclerosis compared with those of the non-CVD subjects. Finally, it was concluded that the IL-15 mutations may play an essential role in the development and prognostic prediction of blood vessel atherosclerosis. https://zancojournal.su.edu.krd/index.php/JPAS/article/view/734AtherosclerosisC-reactive proteinHemoglobin A1cInterleukin-15Troponin T-hs |
| spellingShingle | Sarbaz I. Mohammed Mutations in the Interleukin-15 Gene as a Molecular Biomarker in the Atherosclerosis Disease. Zanco Journal of Pure and Applied Sciences Atherosclerosis C-reactive protein Hemoglobin A1c Interleukin-15 Troponin T-hs |
| title | Mutations in the Interleukin-15 Gene as a Molecular Biomarker in the Atherosclerosis Disease. |
| title_full | Mutations in the Interleukin-15 Gene as a Molecular Biomarker in the Atherosclerosis Disease. |
| title_fullStr | Mutations in the Interleukin-15 Gene as a Molecular Biomarker in the Atherosclerosis Disease. |
| title_full_unstemmed | Mutations in the Interleukin-15 Gene as a Molecular Biomarker in the Atherosclerosis Disease. |
| title_short | Mutations in the Interleukin-15 Gene as a Molecular Biomarker in the Atherosclerosis Disease. |
| title_sort | mutations in the interleukin 15 gene as a molecular biomarker in the atherosclerosis disease |
| topic | Atherosclerosis C-reactive protein Hemoglobin A1c Interleukin-15 Troponin T-hs |
| url | https://zancojournal.su.edu.krd/index.php/JPAS/article/view/734 |
| work_keys_str_mv | AT sarbazimohammed mutationsintheinterleukin15geneasamolecularbiomarkerintheatherosclerosisdisease |