Polycomb Repression without Bristles: Facultative Heterochromatin and Genome Stability in Fungi
Genome integrity is essential to maintain cellular function and viability. Consequently, genome instability is frequently associated with dysfunction in cells and associated with plant, animal, and human diseases. One consequence of relaxed genome maintenance that may be less appreciated is an incre...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/11/6/638 |
| _version_ | 1797565705117237248 |
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| author | John B. Ridenour Mareike Möller Michael Freitag |
| author_facet | John B. Ridenour Mareike Möller Michael Freitag |
| author_sort | John B. Ridenour |
| collection | DOAJ |
| description | Genome integrity is essential to maintain cellular function and viability. Consequently, genome instability is frequently associated with dysfunction in cells and associated with plant, animal, and human diseases. One consequence of relaxed genome maintenance that may be less appreciated is an increased potential for rapid adaptation to changing environments in all organisms. Here, we discuss evidence for the control and function of facultative heterochromatin, which is delineated by methylation of histone H3 lysine 27 (H3K27me) in many fungi. Aside from its relatively well understood role in transcriptional repression, accumulating evidence suggests that H3K27 methylation has an important role in controlling the balance between maintenance and generation of novelty in fungal genomes. We present a working model for a minimal repressive network mediated by H3K27 methylation in fungi and outline challenges for future research. |
| first_indexed | 2024-03-10T19:15:50Z |
| format | Article |
| id | doaj.art-3ab25ce8224c438b8a6e0759401dddb4 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T19:15:50Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-3ab25ce8224c438b8a6e0759401dddb42023-11-20T03:21:06ZengMDPI AGGenes2073-44252020-06-0111663810.3390/genes11060638Polycomb Repression without Bristles: Facultative Heterochromatin and Genome Stability in FungiJohn B. Ridenour0Mareike Möller1Michael Freitag2Department of Biochemistry and Biophysics, Oregon State University, Corvallis OR 97331, USADepartment of Biochemistry and Biophysics, Oregon State University, Corvallis OR 97331, USADepartment of Biochemistry and Biophysics, Oregon State University, Corvallis OR 97331, USAGenome integrity is essential to maintain cellular function and viability. Consequently, genome instability is frequently associated with dysfunction in cells and associated with plant, animal, and human diseases. One consequence of relaxed genome maintenance that may be less appreciated is an increased potential for rapid adaptation to changing environments in all organisms. Here, we discuss evidence for the control and function of facultative heterochromatin, which is delineated by methylation of histone H3 lysine 27 (H3K27me) in many fungi. Aside from its relatively well understood role in transcriptional repression, accumulating evidence suggests that H3K27 methylation has an important role in controlling the balance between maintenance and generation of novelty in fungal genomes. We present a working model for a minimal repressive network mediated by H3K27 methylation in fungi and outline challenges for future research.https://www.mdpi.com/2073-4425/11/6/638<i>Cryptococcus</i>fungi<i>Fusarium</i>histoneslysine methylation<i>Neurospora</i> |
| spellingShingle | John B. Ridenour Mareike Möller Michael Freitag Polycomb Repression without Bristles: Facultative Heterochromatin and Genome Stability in Fungi Genes <i>Cryptococcus</i> fungi <i>Fusarium</i> histones lysine methylation <i>Neurospora</i> |
| title | Polycomb Repression without Bristles: Facultative Heterochromatin and Genome Stability in Fungi |
| title_full | Polycomb Repression without Bristles: Facultative Heterochromatin and Genome Stability in Fungi |
| title_fullStr | Polycomb Repression without Bristles: Facultative Heterochromatin and Genome Stability in Fungi |
| title_full_unstemmed | Polycomb Repression without Bristles: Facultative Heterochromatin and Genome Stability in Fungi |
| title_short | Polycomb Repression without Bristles: Facultative Heterochromatin and Genome Stability in Fungi |
| title_sort | polycomb repression without bristles facultative heterochromatin and genome stability in fungi |
| topic | <i>Cryptococcus</i> fungi <i>Fusarium</i> histones lysine methylation <i>Neurospora</i> |
| url | https://www.mdpi.com/2073-4425/11/6/638 |
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