Hantavirus-induced disruption of the endothelial barrier: Neutrophils are on the payroll
Viral hemorrhagic fever caused by hantaviruses is an emerging infectious disease for which suita-ble treatments are not available. In order to improve this situation a better understanding of han-taviral pathogenesis is urgently required. Hantaviruses infect endothelial cell layers in vitro with-out...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-03-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00222/full |
| _version_ | 1811196848843522048 |
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| author | Günther eSchönrich Detlev H. Krüger Martin John Raftery |
| author_facet | Günther eSchönrich Detlev H. Krüger Martin John Raftery |
| author_sort | Günther eSchönrich |
| collection | DOAJ |
| description | Viral hemorrhagic fever caused by hantaviruses is an emerging infectious disease for which suita-ble treatments are not available. In order to improve this situation a better understanding of han-taviral pathogenesis is urgently required. Hantaviruses infect endothelial cell layers in vitro with-out causing any cytopathogenic effect and without increasing permeability. This implies that the mechanisms underlying vascular hyperpermeability in hantavirus-associated disease are more complex and that immune mechanisms play an important role. In this review we highlight the lat-est developments in hantavirus-induced immunopathogenesis. A possible contribution of neutro-phils has been neglected so far. For this reason, we place special emphasis on the pathogenic role of neutrophils in disrupting the endothelial barrier. |
| first_indexed | 2024-04-12T01:05:23Z |
| format | Article |
| id | doaj.art-3ab3598f7e5e40d08e11eeaf52397bf4 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-12T01:05:23Z |
| publishDate | 2015-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-3ab3598f7e5e40d08e11eeaf52397bf42022-12-22T03:54:16ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2015-03-01610.3389/fmicb.2015.00222129503Hantavirus-induced disruption of the endothelial barrier: Neutrophils are on the payrollGünther eSchönrich0Detlev H. Krüger1Martin John Raftery2Charité-Universitätsmedizin BerlinCharité-Universitätsmedizin BerlinCharité-Universitätsmedizin BerlinViral hemorrhagic fever caused by hantaviruses is an emerging infectious disease for which suita-ble treatments are not available. In order to improve this situation a better understanding of han-taviral pathogenesis is urgently required. Hantaviruses infect endothelial cell layers in vitro with-out causing any cytopathogenic effect and without increasing permeability. This implies that the mechanisms underlying vascular hyperpermeability in hantavirus-associated disease are more complex and that immune mechanisms play an important role. In this review we highlight the lat-est developments in hantavirus-induced immunopathogenesis. A possible contribution of neutro-phils has been neglected so far. For this reason, we place special emphasis on the pathogenic role of neutrophils in disrupting the endothelial barrier.http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00222/fullNeutrophilsImmunopathogenesisviral hemorrhagic feverhantavirusesvascular hyper-permability |
| spellingShingle | Günther eSchönrich Detlev H. Krüger Martin John Raftery Hantavirus-induced disruption of the endothelial barrier: Neutrophils are on the payroll Frontiers in Microbiology Neutrophils Immunopathogenesis viral hemorrhagic fever hantaviruses vascular hyper-permability |
| title | Hantavirus-induced disruption of the endothelial barrier: Neutrophils are on the payroll |
| title_full | Hantavirus-induced disruption of the endothelial barrier: Neutrophils are on the payroll |
| title_fullStr | Hantavirus-induced disruption of the endothelial barrier: Neutrophils are on the payroll |
| title_full_unstemmed | Hantavirus-induced disruption of the endothelial barrier: Neutrophils are on the payroll |
| title_short | Hantavirus-induced disruption of the endothelial barrier: Neutrophils are on the payroll |
| title_sort | hantavirus induced disruption of the endothelial barrier neutrophils are on the payroll |
| topic | Neutrophils Immunopathogenesis viral hemorrhagic fever hantaviruses vascular hyper-permability |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00222/full |
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