Mouth opening/breathing is common in sleep apnea and linked to more nocturnal water loss
Background: Mouth opening/breathing during sleep is common in patients with obstructive sleep apnea (OSA), which is probably associated with more water loss and higher risk for nocturnal ischemic heart attack. This study aimed to evaluate nocturnal changes in hematocrit/hemoglobin levels and estimat...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Biomedical Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2319417022000737 |
| _version_ | 1797792581729386496 |
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| author | Vincent Yi-Fong Su Kun-Ta Chou Chun-Hsien Tseng Chia-Yu Kuo Kang-Cheng Su Diahn-Warng Perng Yuh-Min Chen Shi-Chuan Chang |
| author_facet | Vincent Yi-Fong Su Kun-Ta Chou Chun-Hsien Tseng Chia-Yu Kuo Kang-Cheng Su Diahn-Warng Perng Yuh-Min Chen Shi-Chuan Chang |
| author_sort | Vincent Yi-Fong Su |
| collection | DOAJ |
| description | Background: Mouth opening/breathing during sleep is common in patients with obstructive sleep apnea (OSA), which is probably associated with more water loss and higher risk for nocturnal ischemic heart attack. This study aimed to evaluate nocturnal changes in hematocrit/hemoglobin levels and estimated plasma volume loss in OSA patients and its relation to their OSA severity and mouth open/breathing. Methods: Sixty OSA patients and fifteen healthy controls were enrolled and underwent overnight polysomnography. Mouth status was evaluated via an infrared camera and nasal/mouth airflow. Hematocrit and hemoglobin levels in peripheral venous blood were measured before and after sleep to estimate the change of plasma volume. Results: Compared to controls, OSA patients had a greater nocturnal increase in hematocrit (1.35% vs. 1.0%, p = 0.013), hemoglobin (0.50% vs. 0.30%, p = 0.002) and more estimated water loss (5.5% vs 3.7% of plasma volume, p < 0.013). The extent of increase was correlated to apnea-hypopnea index (AHI)_the marker of OSA severity (Spearman's ρ = 0.332, p = 0.004; ρ = 0.367, p = 0.001 for hematocrit, hemoglobin, respectively), which remained significant after serial multivariate adjustment. OSA patients had more sleep time with mouth open (96.7% vs 26.7% of total sleep time, p < 0.001) and time with complete mouth breathing (14.1% vs 2.7%, p < 0.001). The extent of mouth breathing was correlated to AHI (ρ=0.487, p < 0.001), nocturnal increase in hematocrit/hemoglobin levels (ρ = 0.236, p = 0.042; ρ = 0.304, p = 0.008, respectively) and estimated plasma volume loss (ρ = 0.262, p = 0.023). Conclusion: OSA patients had a greater increase in hematocrit/hemoglobin levels after sleep, which is probably linked to more water loss and more sleep time with mouth open/breathing. |
| first_indexed | 2024-03-13T02:36:08Z |
| format | Article |
| id | doaj.art-3ab36c2baa1f4b5eb19dd98b15bd2c82 |
| institution | Directory Open Access Journal |
| issn | 2319-4170 |
| language | English |
| last_indexed | 2024-03-13T02:36:08Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedical Journal |
| spelling | doaj.art-3ab36c2baa1f4b5eb19dd98b15bd2c822023-06-29T04:14:24ZengElsevierBiomedical Journal2319-41702023-06-01463100536Mouth opening/breathing is common in sleep apnea and linked to more nocturnal water lossVincent Yi-Fong Su0Kun-Ta Chou1Chun-Hsien Tseng2Chia-Yu Kuo3Kang-Cheng Su4Diahn-Warng Perng5Yuh-Min Chen6Shi-Chuan Chang7Department of Internal Medicine, Taipei City Hospital, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan; Faculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan; Center of Sleep Medicine, Taipei Veterans General Hospital, Taipei, TaiwanInstitute of Clinical Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan; Faculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan; Center of Sleep Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Corresponding author. Department of Chest Medicine & Center of Sleep Medicine, Taipei Veterans General Hospital, 201, Sec. 2, Shi-Pai Rd., Taipei 112, Taiwan.Center of Sleep Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, TaiwanCenter of Sleep Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, TaiwanFaculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan; Center of Sleep Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, TaiwanFaculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan; Center of Sleep Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, TaiwanFaculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan; Center of Sleep Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, TaiwanFaculty of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan; Center of Sleep Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, TaiwanBackground: Mouth opening/breathing during sleep is common in patients with obstructive sleep apnea (OSA), which is probably associated with more water loss and higher risk for nocturnal ischemic heart attack. This study aimed to evaluate nocturnal changes in hematocrit/hemoglobin levels and estimated plasma volume loss in OSA patients and its relation to their OSA severity and mouth open/breathing. Methods: Sixty OSA patients and fifteen healthy controls were enrolled and underwent overnight polysomnography. Mouth status was evaluated via an infrared camera and nasal/mouth airflow. Hematocrit and hemoglobin levels in peripheral venous blood were measured before and after sleep to estimate the change of plasma volume. Results: Compared to controls, OSA patients had a greater nocturnal increase in hematocrit (1.35% vs. 1.0%, p = 0.013), hemoglobin (0.50% vs. 0.30%, p = 0.002) and more estimated water loss (5.5% vs 3.7% of plasma volume, p < 0.013). The extent of increase was correlated to apnea-hypopnea index (AHI)_the marker of OSA severity (Spearman's ρ = 0.332, p = 0.004; ρ = 0.367, p = 0.001 for hematocrit, hemoglobin, respectively), which remained significant after serial multivariate adjustment. OSA patients had more sleep time with mouth open (96.7% vs 26.7% of total sleep time, p < 0.001) and time with complete mouth breathing (14.1% vs 2.7%, p < 0.001). The extent of mouth breathing was correlated to AHI (ρ=0.487, p < 0.001), nocturnal increase in hematocrit/hemoglobin levels (ρ = 0.236, p = 0.042; ρ = 0.304, p = 0.008, respectively) and estimated plasma volume loss (ρ = 0.262, p = 0.023). Conclusion: OSA patients had a greater increase in hematocrit/hemoglobin levels after sleep, which is probably linked to more water loss and more sleep time with mouth open/breathing.http://www.sciencedirect.com/science/article/pii/S2319417022000737Obstructive sleep apneaSleep-disordered breathingHematocritHemoconcentrationMouth breathingWater loss |
| spellingShingle | Vincent Yi-Fong Su Kun-Ta Chou Chun-Hsien Tseng Chia-Yu Kuo Kang-Cheng Su Diahn-Warng Perng Yuh-Min Chen Shi-Chuan Chang Mouth opening/breathing is common in sleep apnea and linked to more nocturnal water loss Biomedical Journal Obstructive sleep apnea Sleep-disordered breathing Hematocrit Hemoconcentration Mouth breathing Water loss |
| title | Mouth opening/breathing is common in sleep apnea and linked to more nocturnal water loss |
| title_full | Mouth opening/breathing is common in sleep apnea and linked to more nocturnal water loss |
| title_fullStr | Mouth opening/breathing is common in sleep apnea and linked to more nocturnal water loss |
| title_full_unstemmed | Mouth opening/breathing is common in sleep apnea and linked to more nocturnal water loss |
| title_short | Mouth opening/breathing is common in sleep apnea and linked to more nocturnal water loss |
| title_sort | mouth opening breathing is common in sleep apnea and linked to more nocturnal water loss |
| topic | Obstructive sleep apnea Sleep-disordered breathing Hematocrit Hemoconcentration Mouth breathing Water loss |
| url | http://www.sciencedirect.com/science/article/pii/S2319417022000737 |
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