Revised Temperament and Character Inventory factors predict neuropsychiatric symptoms and aging-related cognitive decline across 25 years
IntroductionPersonality traits and neuropsychiatric symptoms such as neuroticism and depression share genetic overlap and have both been identified as risks factors for development of aging-related neurocognitive decline and Alzheimer’s disease (AD). This study aimed to examine revised personality f...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1335336/full |
| _version_ | 1797301313986363392 |
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| author | Lucas Ronat Lucas Ronat Lucas Ronat Lucas Ronat Michael Rönnlund Rolf Adolfsson Alexandru Hanganu Alexandru Hanganu Sara Pudas Sara Pudas |
| author_facet | Lucas Ronat Lucas Ronat Lucas Ronat Lucas Ronat Michael Rönnlund Rolf Adolfsson Alexandru Hanganu Alexandru Hanganu Sara Pudas Sara Pudas |
| author_sort | Lucas Ronat |
| collection | DOAJ |
| description | IntroductionPersonality traits and neuropsychiatric symptoms such as neuroticism and depression share genetic overlap and have both been identified as risks factors for development of aging-related neurocognitive decline and Alzheimer’s disease (AD). This study aimed to examine revised personality factors derived from the Temperament and Character Inventory, previously shown to be associated with psychiatric disorders, as predictors of neuropsychiatric, cognitive, and brain trajectories of participants from a population-based aging study.MethodsMixed-effect linear regression analyses were conducted on data for the full sample (Nmax = 1,286), and a healthy subsample not converting to AD-dementia during 25-year follow-up (Nmax = 1,145), complemented with Cox proportional regression models to determine risk factors for conversion to clinical AD.ResultsTwo personality factors, Closeness to Experience (CE: avoidance of new stimuli, high anxiety, pessimistic anticipation, low reward seeking) and Tendence to Liabilities (TL: inability to change, low autonomy, unaware of the value of their existence) were associated with higher levels of depressive symptoms, stress (CE), sleep disturbance (TL), as well as greater decline in memory, vocabulary and verbal fluency in the full sample. Higher CE was additionally associated with greater memory decline across 25 years in the healthy subsample, and faster right hippocampal volume reduction across 8 years in a neuroimaging subsample (N = 216). Most, but not all, personality-cognition associations persisted after controlling for diabetes, hypertension and cardiovascular disease. Concerning risks for conversion to AD, higher age, and APOE-ε4, but none of the personality measures, were significant predictors.ConclusionThe results indicate that personality traits associated with psychiatric symptoms predict accelerated age-related neurocognitive declines even in the absence of neurodegenerative disease. The attenuation of some personality effects on cognition after adjustment for health indicators suggests that those effects may be partly mediated by somatic health. Taken together, the results further emphasize the importance of personality traits in neurocognitive aging and underscore the need for an integrative (biopsychosocial) perspective of normal and pathological age-related cognitive decline. |
| first_indexed | 2024-03-07T23:20:45Z |
| format | Article |
| id | doaj.art-3ab661c4baed46bbabcfb202ff9d99cd |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-07T23:20:45Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-3ab661c4baed46bbabcfb202ff9d99cd2024-02-21T05:50:28ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652024-02-011610.3389/fnagi.2024.13353361335336Revised Temperament and Character Inventory factors predict neuropsychiatric symptoms and aging-related cognitive decline across 25 yearsLucas Ronat0Lucas Ronat1Lucas Ronat2Lucas Ronat3Michael Rönnlund4Rolf Adolfsson5Alexandru Hanganu6Alexandru Hanganu7Sara Pudas8Sara Pudas9Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal, Neuroimaging of Emotions Lab, Montreal, QC, CanadaDepartment of Medicine, Faculty of Medicine, University of Montreal, Montreal, QC, CanadaDepartment of Medical and Translational Biology, Umeå University, Umeå, SwedenUmeå Center for Functional Brain Imaging, Umeå University, Umeå, SwedenDepartment of Psychology, Umeå University, Umeå, SwedenDepartment of Clinical Sciences, Umeå University, Umeå, SwedenCentre de Recherche de l’Institut Universitaire de Gériatrie de Montréal, Neuroimaging of Emotions Lab, Montreal, QC, CanadaDepartment of Psychology, Faculty of Arts and Sciences, University of Montreal, Montreal, QC, CanadaDepartment of Medical and Translational Biology, Umeå University, Umeå, SwedenUmeå Center for Functional Brain Imaging, Umeå University, Umeå, SwedenIntroductionPersonality traits and neuropsychiatric symptoms such as neuroticism and depression share genetic overlap and have both been identified as risks factors for development of aging-related neurocognitive decline and Alzheimer’s disease (AD). This study aimed to examine revised personality factors derived from the Temperament and Character Inventory, previously shown to be associated with psychiatric disorders, as predictors of neuropsychiatric, cognitive, and brain trajectories of participants from a population-based aging study.MethodsMixed-effect linear regression analyses were conducted on data for the full sample (Nmax = 1,286), and a healthy subsample not converting to AD-dementia during 25-year follow-up (Nmax = 1,145), complemented with Cox proportional regression models to determine risk factors for conversion to clinical AD.ResultsTwo personality factors, Closeness to Experience (CE: avoidance of new stimuli, high anxiety, pessimistic anticipation, low reward seeking) and Tendence to Liabilities (TL: inability to change, low autonomy, unaware of the value of their existence) were associated with higher levels of depressive symptoms, stress (CE), sleep disturbance (TL), as well as greater decline in memory, vocabulary and verbal fluency in the full sample. Higher CE was additionally associated with greater memory decline across 25 years in the healthy subsample, and faster right hippocampal volume reduction across 8 years in a neuroimaging subsample (N = 216). Most, but not all, personality-cognition associations persisted after controlling for diabetes, hypertension and cardiovascular disease. Concerning risks for conversion to AD, higher age, and APOE-ε4, but none of the personality measures, were significant predictors.ConclusionThe results indicate that personality traits associated with psychiatric symptoms predict accelerated age-related neurocognitive declines even in the absence of neurodegenerative disease. The attenuation of some personality effects on cognition after adjustment for health indicators suggests that those effects may be partly mediated by somatic health. Taken together, the results further emphasize the importance of personality traits in neurocognitive aging and underscore the need for an integrative (biopsychosocial) perspective of normal and pathological age-related cognitive decline.https://www.frontiersin.org/articles/10.3389/fnagi.2024.1335336/fullpersonalitycognitive declineneuropsychiatric symptomsAlzheimer’s dementiaMRIlongitudinal study |
| spellingShingle | Lucas Ronat Lucas Ronat Lucas Ronat Lucas Ronat Michael Rönnlund Rolf Adolfsson Alexandru Hanganu Alexandru Hanganu Sara Pudas Sara Pudas Revised Temperament and Character Inventory factors predict neuropsychiatric symptoms and aging-related cognitive decline across 25 years Frontiers in Aging Neuroscience personality cognitive decline neuropsychiatric symptoms Alzheimer’s dementia MRI longitudinal study |
| title | Revised Temperament and Character Inventory factors predict neuropsychiatric symptoms and aging-related cognitive decline across 25 years |
| title_full | Revised Temperament and Character Inventory factors predict neuropsychiatric symptoms and aging-related cognitive decline across 25 years |
| title_fullStr | Revised Temperament and Character Inventory factors predict neuropsychiatric symptoms and aging-related cognitive decline across 25 years |
| title_full_unstemmed | Revised Temperament and Character Inventory factors predict neuropsychiatric symptoms and aging-related cognitive decline across 25 years |
| title_short | Revised Temperament and Character Inventory factors predict neuropsychiatric symptoms and aging-related cognitive decline across 25 years |
| title_sort | revised temperament and character inventory factors predict neuropsychiatric symptoms and aging related cognitive decline across 25 years |
| topic | personality cognitive decline neuropsychiatric symptoms Alzheimer’s dementia MRI longitudinal study |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1335336/full |
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