Vaccination with short-term-cultured autologous PBMCs efficiently activated STLV-1-specific CTLs in naturally STLV-1-infected Japanese monkeys with impaired CTL responses.

Vaccination with short-term-cultured autologous PBMCs efficiently activated STLV-1-specific CTLs in naturally STLV-1-infected Japanese monkeys with impaired CTL responses.

A small proportion of human T-cell leukemia virus type-1 (HTLV-1)-infected individuals develop adult T-cell leukemia/lymphoma, a chemotherapy-resistant lymphoproliferative disease with a poor prognosis. HTLV-1-specific cytotoxic T lymphocytes (CTLs), potential anti-tumor/virus effectors, are impaire...

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Main Authors: Atsuhiko Hasegawa, Megumi Murata, Tomoka Fujikawa, Kuniko Katagiri, Yoshiko Nagano, Takao Masuda, Madoka Kuramitsu, Shinsuke Nakajima, Jun-Ichi Fujisawa, Kazu Okuma, Poonam Grover, Maureen Kidiga, Hirofumi Akari, Mari Kannagi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011104

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