New data on the effect of A-type botulinum toxin on the colon smooth muscles in the experiment
A-type botulinum toxin blocks presynaptic production of acetylcholine, thereby disrupting neuromuscular transmission, and leading to flaccid muscle paresis. Injection of toxin into the internal anal sphincter is a new, minimally invasive, effective method of treating children with hypertonicity / ac...
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| Format: | Article |
| Language: | Russian |
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Ltd. “The National Academy of Pediatric Science and Innovation”
2022-01-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/1535 |
| _version_ | 1797875090780585984 |
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| author | E. S. Pimenova G. A. Korolev A. A. Zagrebina O. E. Romanova D. A. Morozov |
| author_facet | E. S. Pimenova G. A. Korolev A. A. Zagrebina O. E. Romanova D. A. Morozov |
| author_sort | E. S. Pimenova |
| collection | DOAJ |
| description | A-type botulinum toxin blocks presynaptic production of acetylcholine, thereby disrupting neuromuscular transmission, and leading to flaccid muscle paresis. Injection of toxin into the internal anal sphincter is a new, minimally invasive, effective method of treating children with hypertonicity / achalasia of the sphincter, pelvic muscle dyssynergia, stool retention, secondary fecal incontinence from rectal overflow. The effect of A-type botulinum toxin on smooth muscles of hollow organs has not been yet studied.Objective. To analyze the effect of A-type botulinum toxin on the tone of the smooth muscles of the colon in the experiment.Material and methods. The scientists examined 15 laboratory Sprague Dawley rats. The effect of A-type botulinum toxin on the tone of the smooth muscles of the large intestine was assessed by measuring the stress of the intestinal wall and intraluminal pressure.Results. The scientists revealed a decrease in pressure in the rectum on the 10th day after the injection of A-type botulinum toxin into the segment of the descending colon. The indices of the intestinal wall tension did not differ before the administration of A-type botulinum toxin, as well as in 10 and 20 minutes. The tension in the administration area of A-type botulinum toxin decreased by 81% on the 10th day after injection. There was an indirect decrease in smooth muscle tone in the segments of the colon above and below the injection by 49 and 80%, respectively.Conclusion. The decrease in rectal pressure on the 10th day after the administration of A-type botulinum toxin directly depends upon the decrease in the biovoltage of the overlying sections. Further basic research is needed to assess the effect of the toxin on non-targeted smooth muscle. |
| first_indexed | 2024-04-10T01:41:11Z |
| format | Article |
| id | doaj.art-3ab857bf85f14112906e8eb4d9261cbf |
| institution | Directory Open Access Journal |
| issn | 1027-4065 2500-2228 |
| language | Russian |
| last_indexed | 2024-04-10T01:41:11Z |
| publishDate | 2022-01-01 |
| publisher | Ltd. “The National Academy of Pediatric Science and Innovation” |
| record_format | Article |
| series | Rossijskij Vestnik Perinatologii i Pediatrii |
| spelling | doaj.art-3ab857bf85f14112906e8eb4d9261cbf2023-03-13T09:12:52ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282022-01-01666889310.21508/1027-4065-2021-66-6-88-931138New data on the effect of A-type botulinum toxin on the colon smooth muscles in the experimentE. S. Pimenova0G. A. Korolev1A. A. Zagrebina2O. E. Romanova3D. A. Morozov4ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет); ГБУЗ «Детская городская клиническая больница №9 им. Г.Н. Сперанского» ДЗМФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет)ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет)ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет)ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет); ГБУЗ «Детская городская клиническая больница №9 им. Г.Н. Сперанского» ДЗМ; ОСП «Научно-исследовательский клинический институт педиатрии им. академика Ю.Е. Вельтищева» ФГАОУ ВО РНИМУ им. Н.И. Пирогова Минздрава РоссииA-type botulinum toxin blocks presynaptic production of acetylcholine, thereby disrupting neuromuscular transmission, and leading to flaccid muscle paresis. Injection of toxin into the internal anal sphincter is a new, minimally invasive, effective method of treating children with hypertonicity / achalasia of the sphincter, pelvic muscle dyssynergia, stool retention, secondary fecal incontinence from rectal overflow. The effect of A-type botulinum toxin on smooth muscles of hollow organs has not been yet studied.Objective. To analyze the effect of A-type botulinum toxin on the tone of the smooth muscles of the colon in the experiment.Material and methods. The scientists examined 15 laboratory Sprague Dawley rats. The effect of A-type botulinum toxin on the tone of the smooth muscles of the large intestine was assessed by measuring the stress of the intestinal wall and intraluminal pressure.Results. The scientists revealed a decrease in pressure in the rectum on the 10th day after the injection of A-type botulinum toxin into the segment of the descending colon. The indices of the intestinal wall tension did not differ before the administration of A-type botulinum toxin, as well as in 10 and 20 minutes. The tension in the administration area of A-type botulinum toxin decreased by 81% on the 10th day after injection. There was an indirect decrease in smooth muscle tone in the segments of the colon above and below the injection by 49 and 80%, respectively.Conclusion. The decrease in rectal pressure on the 10th day after the administration of A-type botulinum toxin directly depends upon the decrease in the biovoltage of the overlying sections. Further basic research is needed to assess the effect of the toxin on non-targeted smooth muscle.https://www.ped-perinatology.ru/jour/article/view/1535детиботулинический токсинзапорэкспериментдиссинергическая дефекация |
| spellingShingle | E. S. Pimenova G. A. Korolev A. A. Zagrebina O. E. Romanova D. A. Morozov New data on the effect of A-type botulinum toxin on the colon smooth muscles in the experiment Rossijskij Vestnik Perinatologii i Pediatrii дети ботулинический токсин запор эксперимент диссинергическая дефекация |
| title | New data on the effect of A-type botulinum toxin on the colon smooth muscles in the experiment |
| title_full | New data on the effect of A-type botulinum toxin on the colon smooth muscles in the experiment |
| title_fullStr | New data on the effect of A-type botulinum toxin on the colon smooth muscles in the experiment |
| title_full_unstemmed | New data on the effect of A-type botulinum toxin on the colon smooth muscles in the experiment |
| title_short | New data on the effect of A-type botulinum toxin on the colon smooth muscles in the experiment |
| title_sort | new data on the effect of a type botulinum toxin on the colon smooth muscles in the experiment |
| topic | дети ботулинический токсин запор эксперимент диссинергическая дефекация |
| url | https://www.ped-perinatology.ru/jour/article/view/1535 |
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