Clinical Evaluation of A New Pathological Classification for Non-small Cell Lung Cancer Based on Histogenesis of Bronchial Tree
Background and objective Due in part to remarkable advances over the past decade in our understanding of lung cancer, there is a pressing need for a revised classification. The aim of this study was to explore and verify the clinical significance of a new molecular classification of non-small cell l...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2018-07-01
|
| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2018.07.05 |
| _version_ | 1828427749286477824 |
|---|---|
| author | Nana WANG Nan JIANG Xiaoqing YANG Lei FANG Qing SUN |
| author_facet | Nana WANG Nan JIANG Xiaoqing YANG Lei FANG Qing SUN |
| author_sort | Nana WANG |
| collection | DOAJ |
| description | Background and objective Due in part to remarkable advances over the past decade in our understanding of lung cancer, there is a pressing need for a revised classification. The aim of this study was to explore and verify the clinical significance of a new molecular classification of non-small cell lung cancer (NSCLC) on the basis of anatomic site of bronchial tree. Methods Double-immunohistochemistry were performed in 105 tumor samples paring with normal lung tissue from non-small cell lung cancer patients by using monoclonal antibody of P63/NapsinA and TTF-1/CK7. By comprehensively analyzing the express profiles of tumors and normal lung tissues, histological characteristics we proposed a brand new pathological classification based on histogenesis for NSCLC and divided them as: bronchiole epithelial cell carcinoma, bronchiole-alveolar cell carcinoma, alveolar cell carcinoma and secretory adenocarcinoma. And to analyze the relationship between this classification and epidermal growth factor receptor (EGFR) mutation and ognosis. Results Further investigation revealed that our new classification showed strong relevancy with EGFR mutations and effective indicators for prognosis. Conclusion The classification system for NSCLC proposed by our research group is convenient for pathological diagnosis and valuable in clinical application. |
| first_indexed | 2024-12-10T17:08:19Z |
| format | Article |
| id | doaj.art-3ab9cdcde94c46d79ced766e8c6bc9bc |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-10T17:08:19Z |
| publishDate | 2018-07-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-3ab9cdcde94c46d79ced766e8c6bc9bc2022-12-22T01:40:24ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872018-07-0121753053510.3779/j.issn.1009-3419.2018.07.05Clinical Evaluation of A New Pathological Classification for
Non-small Cell Lung Cancer Based on Histogenesis of Bronchial TreeNana WANG0Nan JIANG1Xiaoqing YANG2Lei FANG3Qing SUN4Department of Pathology, Qianfoshan Hospit al Affiliated to Shandong University, Jinan 250000, ChinaDepartment of Pathology, Shandong Provincial Hospital West Hospital, Jinan 250022, ChinaDepartment of Pathology, Qianfoshan Hospit al Affiliated to Shandong University, Jinan 250000, ChinaDepartment of Pathology, Qianfoshan Hospit al Affiliated to Shandong University, Jinan 250000, ChinaDepartment of Pathology, Qianfoshan Hospit al Affiliated to Shandong University, Jinan 250000, ChinaBackground and objective Due in part to remarkable advances over the past decade in our understanding of lung cancer, there is a pressing need for a revised classification. The aim of this study was to explore and verify the clinical significance of a new molecular classification of non-small cell lung cancer (NSCLC) on the basis of anatomic site of bronchial tree. Methods Double-immunohistochemistry were performed in 105 tumor samples paring with normal lung tissue from non-small cell lung cancer patients by using monoclonal antibody of P63/NapsinA and TTF-1/CK7. By comprehensively analyzing the express profiles of tumors and normal lung tissues, histological characteristics we proposed a brand new pathological classification based on histogenesis for NSCLC and divided them as: bronchiole epithelial cell carcinoma, bronchiole-alveolar cell carcinoma, alveolar cell carcinoma and secretory adenocarcinoma. And to analyze the relationship between this classification and epidermal growth factor receptor (EGFR) mutation and ognosis. Results Further investigation revealed that our new classification showed strong relevancy with EGFR mutations and effective indicators for prognosis. Conclusion The classification system for NSCLC proposed by our research group is convenient for pathological diagnosis and valuable in clinical application.http://dx.doi.org/10.3779/j.issn.1009-3419.2018.07.05Lung neoplasmsHistogenesisPathological classificationEGFR |
| spellingShingle | Nana WANG Nan JIANG Xiaoqing YANG Lei FANG Qing SUN Clinical Evaluation of A New Pathological Classification for Non-small Cell Lung Cancer Based on Histogenesis of Bronchial Tree Chinese Journal of Lung Cancer Lung neoplasms Histogenesis Pathological classification EGFR |
| title | Clinical Evaluation of A New Pathological Classification for
Non-small Cell Lung Cancer Based on Histogenesis of Bronchial Tree |
| title_full | Clinical Evaluation of A New Pathological Classification for
Non-small Cell Lung Cancer Based on Histogenesis of Bronchial Tree |
| title_fullStr | Clinical Evaluation of A New Pathological Classification for
Non-small Cell Lung Cancer Based on Histogenesis of Bronchial Tree |
| title_full_unstemmed | Clinical Evaluation of A New Pathological Classification for
Non-small Cell Lung Cancer Based on Histogenesis of Bronchial Tree |
| title_short | Clinical Evaluation of A New Pathological Classification for
Non-small Cell Lung Cancer Based on Histogenesis of Bronchial Tree |
| title_sort | clinical evaluation of a new pathological classification for
non small cell lung cancer based on histogenesis of bronchial tree |
| topic | Lung neoplasms Histogenesis Pathological classification EGFR |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2018.07.05 |
| work_keys_str_mv | AT nanawang clinicalevaluationofanewpathologicalclassificationfornonsmallcelllungcancerbasedonhistogenesisofbronchialtree AT nanjiang clinicalevaluationofanewpathologicalclassificationfornonsmallcelllungcancerbasedonhistogenesisofbronchialtree AT xiaoqingyang clinicalevaluationofanewpathologicalclassificationfornonsmallcelllungcancerbasedonhistogenesisofbronchialtree AT leifang clinicalevaluationofanewpathologicalclassificationfornonsmallcelllungcancerbasedonhistogenesisofbronchialtree AT qingsun clinicalevaluationofanewpathologicalclassificationfornonsmallcelllungcancerbasedonhistogenesisofbronchialtree |