NRF2 in Viral Infection
The transcription factor NRF2 is central to redox homeostasis in animal cells and is a well-known driver of chemoresistance in many types of cancer. Recently, new roles have been ascribed to NRF2 which include regulation of antiviral interferon responses and inflammation. In addition, NRF2 is emergi...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/10/9/1491 |
| _version_ | 1797520377601064960 |
|---|---|
| author | Angela Herengt Jacob Thyrsted Christian K. Holm |
| author_facet | Angela Herengt Jacob Thyrsted Christian K. Holm |
| author_sort | Angela Herengt |
| collection | DOAJ |
| description | The transcription factor NRF2 is central to redox homeostasis in animal cells and is a well-known driver of chemoresistance in many types of cancer. Recently, new roles have been ascribed to NRF2 which include regulation of antiviral interferon responses and inflammation. In addition, NRF2 is emerging as an important factor in antiviral immunity through interferon-independent mechanisms. In the review, we give an overview of the scientific progress on the involvement and importance of NRF2 in the context of viral infection. |
| first_indexed | 2024-03-10T07:55:54Z |
| format | Article |
| id | doaj.art-3ab9e4101d5b48ac8dc60526fd35c48b |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T07:55:54Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-3ab9e4101d5b48ac8dc60526fd35c48b2023-11-22T11:49:37ZengMDPI AGAntioxidants2076-39212021-09-01109149110.3390/antiox10091491NRF2 in Viral InfectionAngela Herengt0Jacob Thyrsted1Christian K. Holm2Aarhus Research Center for Innate Immunology, Department of Biomedicine, Aarhus University, 8000 Aarhus, DenmarkAarhus Research Center for Innate Immunology, Department of Biomedicine, Aarhus University, 8000 Aarhus, DenmarkAarhus Research Center for Innate Immunology, Department of Biomedicine, Aarhus University, 8000 Aarhus, DenmarkThe transcription factor NRF2 is central to redox homeostasis in animal cells and is a well-known driver of chemoresistance in many types of cancer. Recently, new roles have been ascribed to NRF2 which include regulation of antiviral interferon responses and inflammation. In addition, NRF2 is emerging as an important factor in antiviral immunity through interferon-independent mechanisms. In the review, we give an overview of the scientific progress on the involvement and importance of NRF2 in the context of viral infection.https://www.mdpi.com/2076-3921/10/9/1491NRF2virusimmunology |
| spellingShingle | Angela Herengt Jacob Thyrsted Christian K. Holm NRF2 in Viral Infection Antioxidants NRF2 virus immunology |
| title | NRF2 in Viral Infection |
| title_full | NRF2 in Viral Infection |
| title_fullStr | NRF2 in Viral Infection |
| title_full_unstemmed | NRF2 in Viral Infection |
| title_short | NRF2 in Viral Infection |
| title_sort | nrf2 in viral infection |
| topic | NRF2 virus immunology |
| url | https://www.mdpi.com/2076-3921/10/9/1491 |
| work_keys_str_mv | AT angelaherengt nrf2inviralinfection AT jacobthyrsted nrf2inviralinfection AT christiankholm nrf2inviralinfection |