Group B Streptococcus: Virulence Factors and Pathogenic Mechanism
Group B Streptococcus (GBS) or <i>Streptococcus agalactiae</i> is a major cause of neonatal mortality. When colonizing the lower genital tract of pregnant women, GBS may cause premature birth and stillbirth. If transmitted to the newborn, it may result in life-threatening illnesses, incl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/10/12/2483 |
| _version_ | 1797456142392098816 |
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| author | Yuxin Liu Jinhui Liu |
| author_facet | Yuxin Liu Jinhui Liu |
| author_sort | Yuxin Liu |
| collection | DOAJ |
| description | Group B Streptococcus (GBS) or <i>Streptococcus agalactiae</i> is a major cause of neonatal mortality. When colonizing the lower genital tract of pregnant women, GBS may cause premature birth and stillbirth. If transmitted to the newborn, it may result in life-threatening illnesses, including sepsis, meningitis, and pneumonia. Moreover, through continuous evolution, GBS can use its original structure and unique factors to greatly improve its survival rate in the human body. This review discusses the key virulence factors that facilitate GBS invasion and colonization and their action mechanisms. A comprehensive understanding of the role of virulence factors in GBS infection is crucial to develop better treatment options and screen potential candidate molecules for the development of the vaccine. |
| first_indexed | 2024-03-09T16:04:04Z |
| format | Article |
| id | doaj.art-3abb4ccaba304cfc8337de5cfadae150 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T16:04:04Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-3abb4ccaba304cfc8337de5cfadae1502023-11-24T16:49:51ZengMDPI AGMicroorganisms2076-26072022-12-011012248310.3390/microorganisms10122483Group B Streptococcus: Virulence Factors and Pathogenic MechanismYuxin Liu0Jinhui Liu1Queen Mary School, Nanchang University, Nanchang 330006, ChinaSchool of Basic Medical Sciences, Nanchang University, Nanchang 330006, ChinaGroup B Streptococcus (GBS) or <i>Streptococcus agalactiae</i> is a major cause of neonatal mortality. When colonizing the lower genital tract of pregnant women, GBS may cause premature birth and stillbirth. If transmitted to the newborn, it may result in life-threatening illnesses, including sepsis, meningitis, and pneumonia. Moreover, through continuous evolution, GBS can use its original structure and unique factors to greatly improve its survival rate in the human body. This review discusses the key virulence factors that facilitate GBS invasion and colonization and their action mechanisms. A comprehensive understanding of the role of virulence factors in GBS infection is crucial to develop better treatment options and screen potential candidate molecules for the development of the vaccine.https://www.mdpi.com/2076-2607/10/12/2483Group B Streptococcusvirulence factorsvaginal colonizationperinatal infectionvaccine |
| spellingShingle | Yuxin Liu Jinhui Liu Group B Streptococcus: Virulence Factors and Pathogenic Mechanism Microorganisms Group B Streptococcus virulence factors vaginal colonization perinatal infection vaccine |
| title | Group B Streptococcus: Virulence Factors and Pathogenic Mechanism |
| title_full | Group B Streptococcus: Virulence Factors and Pathogenic Mechanism |
| title_fullStr | Group B Streptococcus: Virulence Factors and Pathogenic Mechanism |
| title_full_unstemmed | Group B Streptococcus: Virulence Factors and Pathogenic Mechanism |
| title_short | Group B Streptococcus: Virulence Factors and Pathogenic Mechanism |
| title_sort | group b streptococcus virulence factors and pathogenic mechanism |
| topic | Group B Streptococcus virulence factors vaginal colonization perinatal infection vaccine |
| url | https://www.mdpi.com/2076-2607/10/12/2483 |
| work_keys_str_mv | AT yuxinliu groupbstreptococcusvirulencefactorsandpathogenicmechanism AT jinhuiliu groupbstreptococcusvirulencefactorsandpathogenicmechanism |