Interleukin-24-mediated antitumor effects against human glioblastoma via upregulation of P38 MAPK and endogenous TRAIL-induced apoptosis and LC3-II activation-dependent autophagy

Interleukin-24-mediated antitumor effects against human glioblastoma via upregulation of P38 MAPK and endogenous TRAIL-induced apoptosis and LC3-II activation-dependent autophagy

Abstract Background Melanoma differentiation-associated gene 7 (Mda-7) encodes IL-24, which can induce apoptosis in cancer cells. A novel gene therapy approach to treat deadly brain tumors, recombinant mda-7 adenovirus (Ad/mda-7) efficiently kills glioma cells. In this study, we investigated the fac...

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Bibliographic Details
Main Authors: Seyedeh Maliheh Babazadeh, Mohammad Reza Zolfaghari, Mohsen Zargar, Kazem Baesi, Sayed Younes Hosseini, Amir Ghaemi
Format: Article
Language:English
Published: BMC 2023-06-01
Series:BMC Cancer
Subjects:
IL-24
Recombinant adenovirus
Cell apoptosis
Glioblastoma
Antitumor
Autophagy
Online Access:https://doi.org/10.1186/s12885-023-11021-y

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