The effect of recombinant human epidermal growth factor on radiation dermatitis in rectal and anal cancer patients: a self-controlled study
Abstract Background Our previous study reported that recombinant human epidermal growth factor (rhEGF)-triggered EGFR internalization promoted radioresistance. Here, we aimed to evaluate the effect of rhEGF on the skin protection of rectal and anal cancer patients receiving radiotherapy. Methods One...
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-022-10226-x |
| _version_ | 1798044427093016576 |
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| author | Shuai Liu Yun-Long Wang Shu-Ting Shi Guang-Dong Zeng Yi-Wen Song Xiao-Dong Zhang Jian Zheng Xin-Juan Fan Yan-Ping Liu |
| author_facet | Shuai Liu Yun-Long Wang Shu-Ting Shi Guang-Dong Zeng Yi-Wen Song Xiao-Dong Zhang Jian Zheng Xin-Juan Fan Yan-Ping Liu |
| author_sort | Shuai Liu |
| collection | DOAJ |
| description | Abstract Background Our previous study reported that recombinant human epidermal growth factor (rhEGF)-triggered EGFR internalization promoted radioresistance. Here, we aimed to evaluate the effect of rhEGF on the skin protection of rectal and anal cancer patients receiving radiotherapy. Methods One hundred and ninety-three rectal and anal cancer patients who received radiotherapy were prospectively enrolled from January 2019 to December 2020. To perform self-controlled study, the left and right pelvic skin area (separated by midline) were randomly assigned to the rhEGF and control side. The association between radiation dermatitis and factors including rhEGF, the dose of radiotherapy and tumor distance from anal edge were analyzed. Results Among 193 enrolled patients, 41 patients (21.2%) did not develop radiation dermatitis, and 152 patients (78.8%) suffered radiation dermatitis on at least one side of pelvic skin at the end of radiotherapy. For the effect on radiation dermatitis grade, rhEGF had improved effect on 6 (4.0%) patients, detrimental effect on 2 (1.3%) patients, and no effect on 144 (94.7%) patients. Whereas for the effect on radiation dermatitis area, rhEGF showed improved effect on the radiation dermatitis area of 46 (30.2%) patients, detrimental effect on 15 (9.9%) patients, and no effect on 91 (59.9%) patients. The radiation dermatitis area of rhEGF side was significantly smaller than that of control side (P = 0.0007). Conclusions rhEGF is a skin protective reagent for rectal and anal cancer patients receiving radiotherapy. Trial registration Chinese Clinical Trial Registry identifier: ChiCTR1900020842; Date of registration: 20/01/2019. |
| first_indexed | 2024-04-11T23:05:02Z |
| format | Article |
| id | doaj.art-3abc5e7710784e1ab615b533181f1e25 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-11T23:05:02Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-3abc5e7710784e1ab615b533181f1e252022-12-22T03:58:03ZengBMCBMC Cancer1471-24072022-11-012211810.1186/s12885-022-10226-xThe effect of recombinant human epidermal growth factor on radiation dermatitis in rectal and anal cancer patients: a self-controlled studyShuai Liu0Yun-Long Wang1Shu-Ting Shi2Guang-Dong Zeng3Yi-Wen Song4Xiao-Dong Zhang5Jian Zheng6Xin-Juan Fan7Yan-Ping Liu8Department of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen UniversityDepartment of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen UniversityDepartment of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen UniversityDepartment of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen UniversityDepartment of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen UniversityClinical Medicine College, Tianjin Medical UniversityDepartment of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen UniversityGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen UniversityDepartment of Radiation Oncology, The Sixth Affiliated Hospital, Sun Yat-sen UniversityAbstract Background Our previous study reported that recombinant human epidermal growth factor (rhEGF)-triggered EGFR internalization promoted radioresistance. Here, we aimed to evaluate the effect of rhEGF on the skin protection of rectal and anal cancer patients receiving radiotherapy. Methods One hundred and ninety-three rectal and anal cancer patients who received radiotherapy were prospectively enrolled from January 2019 to December 2020. To perform self-controlled study, the left and right pelvic skin area (separated by midline) were randomly assigned to the rhEGF and control side. The association between radiation dermatitis and factors including rhEGF, the dose of radiotherapy and tumor distance from anal edge were analyzed. Results Among 193 enrolled patients, 41 patients (21.2%) did not develop radiation dermatitis, and 152 patients (78.8%) suffered radiation dermatitis on at least one side of pelvic skin at the end of radiotherapy. For the effect on radiation dermatitis grade, rhEGF had improved effect on 6 (4.0%) patients, detrimental effect on 2 (1.3%) patients, and no effect on 144 (94.7%) patients. Whereas for the effect on radiation dermatitis area, rhEGF showed improved effect on the radiation dermatitis area of 46 (30.2%) patients, detrimental effect on 15 (9.9%) patients, and no effect on 91 (59.9%) patients. The radiation dermatitis area of rhEGF side was significantly smaller than that of control side (P = 0.0007). Conclusions rhEGF is a skin protective reagent for rectal and anal cancer patients receiving radiotherapy. Trial registration Chinese Clinical Trial Registry identifier: ChiCTR1900020842; Date of registration: 20/01/2019.https://doi.org/10.1186/s12885-022-10226-xrhEGFRadiation dermatitisRectal and anal cancerClinical trial |
| spellingShingle | Shuai Liu Yun-Long Wang Shu-Ting Shi Guang-Dong Zeng Yi-Wen Song Xiao-Dong Zhang Jian Zheng Xin-Juan Fan Yan-Ping Liu The effect of recombinant human epidermal growth factor on radiation dermatitis in rectal and anal cancer patients: a self-controlled study BMC Cancer rhEGF Radiation dermatitis Rectal and anal cancer Clinical trial |
| title | The effect of recombinant human epidermal growth factor on radiation dermatitis in rectal and anal cancer patients: a self-controlled study |
| title_full | The effect of recombinant human epidermal growth factor on radiation dermatitis in rectal and anal cancer patients: a self-controlled study |
| title_fullStr | The effect of recombinant human epidermal growth factor on radiation dermatitis in rectal and anal cancer patients: a self-controlled study |
| title_full_unstemmed | The effect of recombinant human epidermal growth factor on radiation dermatitis in rectal and anal cancer patients: a self-controlled study |
| title_short | The effect of recombinant human epidermal growth factor on radiation dermatitis in rectal and anal cancer patients: a self-controlled study |
| title_sort | effect of recombinant human epidermal growth factor on radiation dermatitis in rectal and anal cancer patients a self controlled study |
| topic | rhEGF Radiation dermatitis Rectal and anal cancer Clinical trial |
| url | https://doi.org/10.1186/s12885-022-10226-x |
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