Delayed gastric emptying in nondiabetic patients with end-stage kidney disease
Objective This study aimed to assess the gastric emptying capacity in nondiabetic patients with end-stage kidney disease (ESKD) by ultrasound. Methods Consecutive hemodialysis patients with ESKD (n = 37) and healthy controls (n = 37) were enrolled. All ESKD patients underwent ultrasound examinations...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/0886022X.2022.2030754 |
| _version_ | 1828891174912393216 |
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| author | Cuiyu Wang Chao Chen Jin Wang Xiaohua Guo Yuechan. C. Deng Li Liu Chunmei Zhao |
| author_facet | Cuiyu Wang Chao Chen Jin Wang Xiaohua Guo Yuechan. C. Deng Li Liu Chunmei Zhao |
| author_sort | Cuiyu Wang |
| collection | DOAJ |
| description | Objective This study aimed to assess the gastric emptying capacity in nondiabetic patients with end-stage kidney disease (ESKD) by ultrasound. Methods Consecutive hemodialysis patients with ESKD (n = 37) and healthy controls (n = 37) were enrolled. All ESKD patients underwent ultrasound examinations on the day of hemodialysis (dialysis day) and the day after hemodialysis (nondialysis day). Standard ultrasound examinations were performed after overnight fasting, immediately after a light meal, and at 6 h after a meal. The antral cross-sectional area and gastric emptying according to the Perlas grading system were evaluated. Results Compared with the controls, patients with ESKD, on both dialysis and non-dialysis days, had significantly larger antral areas when examined in the supine position (p = 0.002 and p = 0.003, respectively), but not in the right lateral decubitus position (p = 0.452 and p = 0.512, respectively). In the supine position, the antral area of ESKD patients before dialysis (8 a.m. on the dialysis day) was larger than that at the same time on the nondialysis day (p = 0.028). The controls had a Perlas grade of either 0 or 1 at 6 h after a meal, whereas five patients (13.5%) and 11 patients (29.7%) in the ESKD group had Perlas grade 2 on the dialysis and non-dialysis days, respectively. Among patients with or without delayed gastric emptying, no differences were detected in the dialysis duration or levels of biochemical markers, except blood urea nitrogen (p = 0.038) and serum creatinine (p = 0.003). Conclusion Nondiabetic patients with ESKD had significantly delayed gastric emptying. Hemodialysis might improve gastric emptying and reduce gastric emptying delay. |
| first_indexed | 2024-12-13T13:12:35Z |
| format | Article |
| id | doaj.art-3abc6ce370604c94ad13586a69130142 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-12-13T13:12:35Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-3abc6ce370604c94ad13586a691301422022-12-21T23:44:38ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492022-12-0144132933510.1080/0886022X.2022.20307542030754Delayed gastric emptying in nondiabetic patients with end-stage kidney diseaseCuiyu Wang0Chao Chen1Jin Wang2Xiaohua Guo3Yuechan. C. Deng4Li Liu5Chunmei Zhao6Department of Nephrology, Shenzhen Hospital, Southern Medical UniversityDepartment of Anaesthesiology, University of Hong Kong Shenzhen HospitalDepartment of Epidemiology, School of Public Health, Sun Yat-sen UniversityDepartment of Nephrology, Shenzhen Hospital, Southern Medical UniversityDepartment of Nephrology, Shenzhen Hospital, Southern Medical UniversityDepartment of Radiology, University of Hong Kong Shenzhen HospitalDepartment of Nephrology, Shenzhen Hospital, Southern Medical UniversityObjective This study aimed to assess the gastric emptying capacity in nondiabetic patients with end-stage kidney disease (ESKD) by ultrasound. Methods Consecutive hemodialysis patients with ESKD (n = 37) and healthy controls (n = 37) were enrolled. All ESKD patients underwent ultrasound examinations on the day of hemodialysis (dialysis day) and the day after hemodialysis (nondialysis day). Standard ultrasound examinations were performed after overnight fasting, immediately after a light meal, and at 6 h after a meal. The antral cross-sectional area and gastric emptying according to the Perlas grading system were evaluated. Results Compared with the controls, patients with ESKD, on both dialysis and non-dialysis days, had significantly larger antral areas when examined in the supine position (p = 0.002 and p = 0.003, respectively), but not in the right lateral decubitus position (p = 0.452 and p = 0.512, respectively). In the supine position, the antral area of ESKD patients before dialysis (8 a.m. on the dialysis day) was larger than that at the same time on the nondialysis day (p = 0.028). The controls had a Perlas grade of either 0 or 1 at 6 h after a meal, whereas five patients (13.5%) and 11 patients (29.7%) in the ESKD group had Perlas grade 2 on the dialysis and non-dialysis days, respectively. Among patients with or without delayed gastric emptying, no differences were detected in the dialysis duration or levels of biochemical markers, except blood urea nitrogen (p = 0.038) and serum creatinine (p = 0.003). Conclusion Nondiabetic patients with ESKD had significantly delayed gastric emptying. Hemodialysis might improve gastric emptying and reduce gastric emptying delay.http://dx.doi.org/10.1080/0886022X.2022.2030754gastric emptyingend-stage kidney diseasehemodialysisantral areaultrasound |
| spellingShingle | Cuiyu Wang Chao Chen Jin Wang Xiaohua Guo Yuechan. C. Deng Li Liu Chunmei Zhao Delayed gastric emptying in nondiabetic patients with end-stage kidney disease Renal Failure gastric emptying end-stage kidney disease hemodialysis antral area ultrasound |
| title | Delayed gastric emptying in nondiabetic patients with end-stage kidney disease |
| title_full | Delayed gastric emptying in nondiabetic patients with end-stage kidney disease |
| title_fullStr | Delayed gastric emptying in nondiabetic patients with end-stage kidney disease |
| title_full_unstemmed | Delayed gastric emptying in nondiabetic patients with end-stage kidney disease |
| title_short | Delayed gastric emptying in nondiabetic patients with end-stage kidney disease |
| title_sort | delayed gastric emptying in nondiabetic patients with end stage kidney disease |
| topic | gastric emptying end-stage kidney disease hemodialysis antral area ultrasound |
| url | http://dx.doi.org/10.1080/0886022X.2022.2030754 |
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