Patient-reported outcomes provide evidence for increased depressive symptoms and increased mental impairment in giant cell arteritis
ObjectivesThe spectrum of giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) represents highly inflammatory rheumatic diseases. Patients mostly report severe physical impairment. Possible consequences for mental health have been scarcely studied. The aim of this study was to investigate psy...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1146815/full |
| _version_ | 1797816587056578560 |
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| author | Matthias Froehlich Antonia Zahner Marc Schmalzing Michael Gernert Patrick-Pascal Strunz Sebastian Hueper Jan Portegys Eva Christina Schwaneck Ottar Gadeholt Andrea Kübler Johannes Hewig Philipp Ziebell |
| author_facet | Matthias Froehlich Antonia Zahner Marc Schmalzing Michael Gernert Patrick-Pascal Strunz Sebastian Hueper Jan Portegys Eva Christina Schwaneck Ottar Gadeholt Andrea Kübler Johannes Hewig Philipp Ziebell |
| author_sort | Matthias Froehlich |
| collection | DOAJ |
| description | ObjectivesThe spectrum of giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) represents highly inflammatory rheumatic diseases. Patients mostly report severe physical impairment. Possible consequences for mental health have been scarcely studied. The aim of this study was to investigate psychological well-being in the context of GCA and PMR.MethodsCross-sectional study with N = 100 patients with GCA and/or PMR (GCA-PMR). Patient-reported outcomes (PROs) were measured using the Short Form 36 Version 2 (SF-36v2) and visual analog scale (VAS) assessment. Moreover, the Patient Health Questionnaire 9 (PHQ-9) was used in 35 of 100 patients to detect depression. To compare PROs with physician assessment, VAS was also rated from physician perspective. To assess a possible association with inflammation itself, serological parameters of inflammation (C-reactive protein [CRP], erythrocyte sedimentation rate [ESR]) were included.ResultsIn all scales of the SF-36v2 except General Health (GH) and in the physical and mental sum score (PCS, MCS), a significant impairment compared to the German reference collective was evident (MCS: d = 0.533, p < 0.001). In the PHQ-9 categorization, 14 of the 35 (40%) showed evidence of major depression disorder. VAS Patient correlated significantly with PHQ-9 and SF-36 in all categories, while VAS Physician showed only correlations to physical categories and not in the mental dimensions. Regarding inflammatory parameters, linear regression showed CRP to be a complementary significant positive predictor of mental health subscale score, independent of pain.ConclusionPRO show a relevant impairment of mental health up to symptoms of major depression disorder. The degree of depressive symptoms is also distinctly associated with the serological inflammatory marker CRP. |
| first_indexed | 2024-03-13T08:39:50Z |
| format | Article |
| id | doaj.art-3abcbc0a6e2943879000aa7738db2404 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-13T08:39:50Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-3abcbc0a6e2943879000aa7738db24042023-05-30T14:04:22ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-05-011010.3389/fmed.2023.11468151146815Patient-reported outcomes provide evidence for increased depressive symptoms and increased mental impairment in giant cell arteritisMatthias Froehlich0Antonia Zahner1Marc Schmalzing2Michael Gernert3Patrick-Pascal Strunz4Sebastian Hueper5Jan Portegys6Eva Christina Schwaneck7Ottar Gadeholt8Andrea Kübler9Johannes Hewig10Philipp Ziebell11Department of Internal Medicine II, Rheumatology/Clinical Immunology, University Hospital Würzburg, Würzburg, GermanyDepartment of Psychology I, Institute of Psychology, University of Würzburg, Würzburg, GermanyDepartment of Internal Medicine II, Rheumatology/Clinical Immunology, University Hospital Würzburg, Würzburg, GermanyDepartment of Internal Medicine II, Rheumatology/Clinical Immunology, University Hospital Würzburg, Würzburg, GermanyDepartment of Internal Medicine II, Rheumatology/Clinical Immunology, University Hospital Würzburg, Würzburg, GermanyDepartment of Internal Medicine II, Rheumatology/Clinical Immunology, University Hospital Würzburg, Würzburg, GermanyDepartment of Internal Medicine II, Rheumatology/Clinical Immunology, University Hospital Würzburg, Würzburg, GermanyMVZ Rheumatologie und Autoimmunmedizin, Hamburg, GermanyRheumatologische Schwerpunktpraxis Würzburg, Würzburg, GermanyDepartment of Psychology I, Institute of Psychology, University of Würzburg, Würzburg, GermanyDepartment of Psychology I, Institute of Psychology, University of Würzburg, Würzburg, GermanyDepartment of Psychology I, Institute of Psychology, University of Würzburg, Würzburg, GermanyObjectivesThe spectrum of giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) represents highly inflammatory rheumatic diseases. Patients mostly report severe physical impairment. Possible consequences for mental health have been scarcely studied. The aim of this study was to investigate psychological well-being in the context of GCA and PMR.MethodsCross-sectional study with N = 100 patients with GCA and/or PMR (GCA-PMR). Patient-reported outcomes (PROs) were measured using the Short Form 36 Version 2 (SF-36v2) and visual analog scale (VAS) assessment. Moreover, the Patient Health Questionnaire 9 (PHQ-9) was used in 35 of 100 patients to detect depression. To compare PROs with physician assessment, VAS was also rated from physician perspective. To assess a possible association with inflammation itself, serological parameters of inflammation (C-reactive protein [CRP], erythrocyte sedimentation rate [ESR]) were included.ResultsIn all scales of the SF-36v2 except General Health (GH) and in the physical and mental sum score (PCS, MCS), a significant impairment compared to the German reference collective was evident (MCS: d = 0.533, p < 0.001). In the PHQ-9 categorization, 14 of the 35 (40%) showed evidence of major depression disorder. VAS Patient correlated significantly with PHQ-9 and SF-36 in all categories, while VAS Physician showed only correlations to physical categories and not in the mental dimensions. Regarding inflammatory parameters, linear regression showed CRP to be a complementary significant positive predictor of mental health subscale score, independent of pain.ConclusionPRO show a relevant impairment of mental health up to symptoms of major depression disorder. The degree of depressive symptoms is also distinctly associated with the serological inflammatory marker CRP.https://www.frontiersin.org/articles/10.3389/fmed.2023.1146815/fullgiant cell arteritisPROdepressionmental impairmentSF-36PHQ-9 |
| spellingShingle | Matthias Froehlich Antonia Zahner Marc Schmalzing Michael Gernert Patrick-Pascal Strunz Sebastian Hueper Jan Portegys Eva Christina Schwaneck Ottar Gadeholt Andrea Kübler Johannes Hewig Philipp Ziebell Patient-reported outcomes provide evidence for increased depressive symptoms and increased mental impairment in giant cell arteritis Frontiers in Medicine giant cell arteritis PRO depression mental impairment SF-36 PHQ-9 |
| title | Patient-reported outcomes provide evidence for increased depressive symptoms and increased mental impairment in giant cell arteritis |
| title_full | Patient-reported outcomes provide evidence for increased depressive symptoms and increased mental impairment in giant cell arteritis |
| title_fullStr | Patient-reported outcomes provide evidence for increased depressive symptoms and increased mental impairment in giant cell arteritis |
| title_full_unstemmed | Patient-reported outcomes provide evidence for increased depressive symptoms and increased mental impairment in giant cell arteritis |
| title_short | Patient-reported outcomes provide evidence for increased depressive symptoms and increased mental impairment in giant cell arteritis |
| title_sort | patient reported outcomes provide evidence for increased depressive symptoms and increased mental impairment in giant cell arteritis |
| topic | giant cell arteritis PRO depression mental impairment SF-36 PHQ-9 |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1146815/full |
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