Inflammasome inhibitors: promising therapeutic approaches against cancer
Abstract Inflammation has long been accepted as a key component of carcinogenesis. During inflammation, inflammasomes are potent contributors to the activation of inflammatory cytokines that lead to an inflammatory cascade. Considering the contributing role of inflammasomes in cancer progression, in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-06-01
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| Series: | Journal of Hematology & Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13045-019-0755-0 |
| _version_ | 1818554684037660672 |
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| author | Shengchao Xu Xizhe Li Yuanqi Liu Yu Xia Ruimin Chang Chunfang Zhang |
| author_facet | Shengchao Xu Xizhe Li Yuanqi Liu Yu Xia Ruimin Chang Chunfang Zhang |
| author_sort | Shengchao Xu |
| collection | DOAJ |
| description | Abstract Inflammation has long been accepted as a key component of carcinogenesis. During inflammation, inflammasomes are potent contributors to the activation of inflammatory cytokines that lead to an inflammatory cascade. Considering the contributing role of inflammasomes in cancer progression, inflammasome inhibitors seem to have a promising future in cancer treatment and prevention. Here, we summarize the structures and signaling pathways of inflammasomes and detail some inflammasome inhibitors used to treat various forms of cancer, which we expect to be used in novel anticancer approaches. However, the practical application of inflammasome inhibitors is limited in regard to specific types of cancer, and the associated clinical trials have not yet been completed. Therefore, additional studies are required to explore more innovative and effective medicines for future clinical treatment of cancer. |
| first_indexed | 2024-12-12T09:43:13Z |
| format | Article |
| id | doaj.art-3abece6223514646a60f39bb97c9b5f9 |
| institution | Directory Open Access Journal |
| issn | 1756-8722 |
| language | English |
| last_indexed | 2024-12-12T09:43:13Z |
| publishDate | 2019-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj.art-3abece6223514646a60f39bb97c9b5f92022-12-22T00:28:30ZengBMCJournal of Hematology & Oncology1756-87222019-06-0112111310.1186/s13045-019-0755-0Inflammasome inhibitors: promising therapeutic approaches against cancerShengchao Xu0Xizhe Li1Yuanqi Liu2Yu Xia3Ruimin Chang4Chunfang Zhang5Department of Thoracic Surgery, Xiangya Hospital of Central South UniversityDepartment of Thoracic Surgery, Xiangya Hospital of Central South UniversityDepartment of Thoracic Surgery, Xiangya Hospital of Central South UniversityDepartment of Thoracic Surgery, Xiangya Hospital of Central South UniversityDepartment of Thoracic Surgery, Xiangya Hospital of Central South UniversityDepartment of Thoracic Surgery, Xiangya Hospital of Central South UniversityAbstract Inflammation has long been accepted as a key component of carcinogenesis. During inflammation, inflammasomes are potent contributors to the activation of inflammatory cytokines that lead to an inflammatory cascade. Considering the contributing role of inflammasomes in cancer progression, inflammasome inhibitors seem to have a promising future in cancer treatment and prevention. Here, we summarize the structures and signaling pathways of inflammasomes and detail some inflammasome inhibitors used to treat various forms of cancer, which we expect to be used in novel anticancer approaches. However, the practical application of inflammasome inhibitors is limited in regard to specific types of cancer, and the associated clinical trials have not yet been completed. Therefore, additional studies are required to explore more innovative and effective medicines for future clinical treatment of cancer.http://link.springer.com/article/10.1186/s13045-019-0755-0Inflammasome inhibitorsTherapeuticsCancer |
| spellingShingle | Shengchao Xu Xizhe Li Yuanqi Liu Yu Xia Ruimin Chang Chunfang Zhang Inflammasome inhibitors: promising therapeutic approaches against cancer Journal of Hematology & Oncology Inflammasome inhibitors Therapeutics Cancer |
| title | Inflammasome inhibitors: promising therapeutic approaches against cancer |
| title_full | Inflammasome inhibitors: promising therapeutic approaches against cancer |
| title_fullStr | Inflammasome inhibitors: promising therapeutic approaches against cancer |
| title_full_unstemmed | Inflammasome inhibitors: promising therapeutic approaches against cancer |
| title_short | Inflammasome inhibitors: promising therapeutic approaches against cancer |
| title_sort | inflammasome inhibitors promising therapeutic approaches against cancer |
| topic | Inflammasome inhibitors Therapeutics Cancer |
| url | http://link.springer.com/article/10.1186/s13045-019-0755-0 |
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